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Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists.

Abstract

For centuries Cannabis sativa and cannabis extracts have been used in natural medicine. Delta(9)-tetrahydrocannabinol (THC) is the main active ingredient of Cannabis. THC seems to be responsible for most of the pharmacological and therapeutic actions of cannabis. In a few countries THC extracts (i.e. Sativex) or THC derivatives such as nabilone, and dronabinol are used in the clinic for the treatment of several pathological conditions like chemotherapy-induced nausea and vomiting, multiple sclerosis and glaucoma. On the other hand the severe side effects and the high abuse liability of these agents represent a serious limitation in their medical use. In addition, diversion in the use of these active ingredients for recreational purpose is a concern. Over recent years, alternative approaches using synthetic cannabinoid receptor agonists or agents acting as activators of the endocannabinoid systems are under scrutiny with the hope to develop more effective and safer clinical applications. Likely, in the near future few of these new molecules will be available for clinical use. The present article review recent study and patents with focus on the cannabinoid system as a target for the treatment of central nervous system disorders with emphasis on agonists.

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  • Authors+Show Affiliations

    ,

    Health and Human Development Section, Division for Operations, United Nations Office on Drugs and Crime, Room D1438, P.O. Box 500, 1400 Vienna, Austria. gilberto.gerra@unodc.org

    , , , , ,

    Source

    MeSH

    Animals
    Cannabinoid Receptor Modulators
    Cannabinoids
    Cannabis
    Central Nervous System Diseases
    Endocannabinoids
    Humans
    Learning
    Marijuana Abuse
    Patents as Topic
    Phytotherapy
    Receptor, Cannabinoid, CB1

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19832688

    Citation

    Gerra, Gilberto, et al. "Pharmacology and Toxicology of Cannabis Derivatives and Endocannabinoid Agonists." Recent Patents On CNS Drug Discovery, vol. 5, no. 1, 2010, pp. 46-52.
    Gerra G, Zaimovic A, Gerra ML, et al. Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists. Recent Pat CNS Drug Discov. 2010;5(1):46-52.
    Gerra, G., Zaimovic, A., Gerra, M. L., Ciccocioppo, R., Cippitelli, A., Serpelloni, G., & Somaini, L. (2010). Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists. Recent Patents On CNS Drug Discovery, 5(1), pp. 46-52.
    Gerra G, et al. Pharmacology and Toxicology of Cannabis Derivatives and Endocannabinoid Agonists. Recent Pat CNS Drug Discov. 2010;5(1):46-52. PubMed PMID: 19832688.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists. AU - Gerra,Gilberto, AU - Zaimovic,Amir, AU - Gerra,Maria L, AU - Ciccocioppo,Roberto, AU - Cippitelli,Andrea, AU - Serpelloni,Giovanni, AU - Somaini,Lorenzo, PY - 2009/07/09/received PY - 2009/08/21/accepted PY - 2009/10/17/entrez PY - 2009/10/17/pubmed PY - 2010/3/2/medline SP - 46 EP - 52 JF - Recent patents on CNS drug discovery JO - Recent Pat CNS Drug Discov VL - 5 IS - 1 N2 - For centuries Cannabis sativa and cannabis extracts have been used in natural medicine. Delta(9)-tetrahydrocannabinol (THC) is the main active ingredient of Cannabis. THC seems to be responsible for most of the pharmacological and therapeutic actions of cannabis. In a few countries THC extracts (i.e. Sativex) or THC derivatives such as nabilone, and dronabinol are used in the clinic for the treatment of several pathological conditions like chemotherapy-induced nausea and vomiting, multiple sclerosis and glaucoma. On the other hand the severe side effects and the high abuse liability of these agents represent a serious limitation in their medical use. In addition, diversion in the use of these active ingredients for recreational purpose is a concern. Over recent years, alternative approaches using synthetic cannabinoid receptor agonists or agents acting as activators of the endocannabinoid systems are under scrutiny with the hope to develop more effective and safer clinical applications. Likely, in the near future few of these new molecules will be available for clinical use. The present article review recent study and patents with focus on the cannabinoid system as a target for the treatment of central nervous system disorders with emphasis on agonists. SN - 2212-3954 UR - https://www.unboundmedicine.com/medline/citation/19832688/Pharmacology_and_toxicology_of_Cannabis_derivatives_and_endocannabinoid_agonists_ L2 - http://www.eurekaselect.com/85221/article DB - PRIME DP - Unbound Medicine ER -