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The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid.
Food Chem Toxicol. 2010 Jan; 48(1):215-21.FC

Abstract

Pesticides may induce oxidative stress leading to generate free radicals and alternate antioxidant or oxygen free radical scavenging enzyme system. This study was conducted to investigate the acute toxicity of imidacloprid toward male mice and the oxidative stress of the sublethal dose (1/10 LD(50)) on the lipid peroxidation level (LPO), reduced glutathione content (GSH) and activities of the antioxidant enzymes; catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PD), and glutathione-s-transferase (GST). Also, the protective effect of vitamin C (200mg/kg bw) 30 min before or after administration of imidacloprid were investigated. The results demonstrated that the median lethal dose (LD(50)) of imidacloprid after 24h was 149.76 mg/kg bw. The oral administration of 14.976 mg/kg imidacloprid significantly caused elevation in LPO level and the activities of antioxidant enzymes including CAT, SOD, GPx and GST. However, G6PD activity remained unchanged, while the level of GSH content was decreased. In addition, the results showed that vitamin C might ameliorate imidacloprid-induced oxidative damage by decreasing LPO and altering antioxidant defense system in liver. The protective effect of the pre-treatment with vitamin C against imidacloprid-induced oxidative stress in liver mice is better than the post-treatment.

Authors+Show Affiliations

Dept of Pesticide Chemistry, Faculty of Agriculture, Alexandria, Egypt. kawther52@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19833166

Citation

El-Gendy, Kawther S., et al. "The Role of Vitamin C as Antioxidant in Protection of Oxidative Stress Induced By Imidacloprid." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 1, 2010, pp. 215-21.
El-Gendy KS, Aly NM, Mahmoud FH, et al. The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid. Food Chem Toxicol. 2010;48(1):215-21.
El-Gendy, K. S., Aly, N. M., Mahmoud, F. H., Kenawy, A., & El-Sebae, A. K. (2010). The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(1), 215-21. https://doi.org/10.1016/j.fct.2009.10.003
El-Gendy KS, et al. The Role of Vitamin C as Antioxidant in Protection of Oxidative Stress Induced By Imidacloprid. Food Chem Toxicol. 2010;48(1):215-21. PubMed PMID: 19833166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vitamin C as antioxidant in protection of oxidative stress induced by imidacloprid. AU - El-Gendy,Kawther S, AU - Aly,Nagat M, AU - Mahmoud,Fatma H, AU - Kenawy,Anter, AU - El-Sebae,Abdel Khalek H, Y1 - 2009/10/13/ PY - 2009/05/17/received PY - 2009/09/30/revised PY - 2009/10/01/accepted PY - 2009/10/17/entrez PY - 2009/10/17/pubmed PY - 2010/4/16/medline SP - 215 EP - 21 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 48 IS - 1 N2 - Pesticides may induce oxidative stress leading to generate free radicals and alternate antioxidant or oxygen free radical scavenging enzyme system. This study was conducted to investigate the acute toxicity of imidacloprid toward male mice and the oxidative stress of the sublethal dose (1/10 LD(50)) on the lipid peroxidation level (LPO), reduced glutathione content (GSH) and activities of the antioxidant enzymes; catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PD), and glutathione-s-transferase (GST). Also, the protective effect of vitamin C (200mg/kg bw) 30 min before or after administration of imidacloprid were investigated. The results demonstrated that the median lethal dose (LD(50)) of imidacloprid after 24h was 149.76 mg/kg bw. The oral administration of 14.976 mg/kg imidacloprid significantly caused elevation in LPO level and the activities of antioxidant enzymes including CAT, SOD, GPx and GST. However, G6PD activity remained unchanged, while the level of GSH content was decreased. In addition, the results showed that vitamin C might ameliorate imidacloprid-induced oxidative damage by decreasing LPO and altering antioxidant defense system in liver. The protective effect of the pre-treatment with vitamin C against imidacloprid-induced oxidative stress in liver mice is better than the post-treatment. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19833166/The_role_of_vitamin_C_as_antioxidant_in_protection_of_oxidative_stress_induced_by_imidacloprid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00463-3 DB - PRIME DP - Unbound Medicine ER -