Tags

Type your tag names separated by a space and hit enter

Qualea parviflora Mart.: an integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action.
J Ethnopharmacol. 2010 Feb 03; 127(2):508-14.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome.

AIM OF THE STUDY

Based on ethnopharmacological data, methanolic extract from Qualea parviflora (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti-Helicobacter pylori activities.

MATERIAL AND METHODS

The gastroprotective action of the extract was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated mutagenic effect (Ames assay), anti-Helicobacter pylori, anti-hemorrhagic action, analgesic and inflammatory effects (hot-plate test and carrageenin-induced hind paw edema) of methanolic extract from Qualea parviflora.

RESULTS

QP (500 mg/kg, p.o.) was able to protect gastric mucosa against HCl/ethanol solution (77%), absolute ethanol (97%), and also against injurious effect of NSAID (36%). When QP was challenged with sulfhydryl depletor compound, the gastroprotective action of extract was abolished. QP treatment was able to maintain the GSH level and show a concentration-dependent inhibition effect on the lipid peroxidation. QP present anti-Helicobacter pylori effect (MIC=75 microg/mL), anti-hemorrhagic and antidiarrheal action but not present analgesic or anti-inflammatory effect.

CONCLUSION

methanolic extract from Qualea parviflora had gastroprotective effect related to the increase of gastric mucosa defensive factors such PGE(2) levels and maintain the basal gastric glutathione levels. The methanolic extract also showed anti-Helicobacter pylori activity, anti-hemorrhagic effect and antioxidant action, but absence of analgesic, mutagenic and toxic effects, a profile that adds safety to its use.

Authors+Show Affiliations

Physiology Department, Biosciences Institute, São Paulo State University-UNESP, cp 510, Zip Code 18618-000 Botucatu, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

19833186

Citation

Mazzolin, Lucilene Patrícia, et al. "Qualea Parviflora Mart.: an Integrative Study to Validate the Gastroprotective, Antidiarrheal, Antihemorragic and Mutagenic Action." Journal of Ethnopharmacology, vol. 127, no. 2, 2010, pp. 508-14.
Mazzolin LP, Nasser AL, Moraes TM, et al. Qualea parviflora Mart.: an integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action. J Ethnopharmacol. 2010;127(2):508-14.
Mazzolin, L. P., Nasser, A. L., Moraes, T. M., Santos, R. C., Nishijima, C. M., Santos, F. V., Varanda, E. A., Bauab, T. M., da Rocha, L. R., Di Stasi, L. C., Vilegas, W., & Hiruma-Lima, C. A. (2010). Qualea parviflora Mart.: an integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action. Journal of Ethnopharmacology, 127(2), 508-14. https://doi.org/10.1016/j.jep.2009.10.005
Mazzolin LP, et al. Qualea Parviflora Mart.: an Integrative Study to Validate the Gastroprotective, Antidiarrheal, Antihemorragic and Mutagenic Action. J Ethnopharmacol. 2010 Feb 3;127(2):508-14. PubMed PMID: 19833186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Qualea parviflora Mart.: an integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action. AU - Mazzolin,Lucilene Patrícia, AU - Nasser,Ana Lúcia Martiniano, AU - Moraes,Thiago Mello, AU - Santos,Raquel Cássia, AU - Nishijima,Catarine Massucato, AU - Santos,Fábio Vieira, AU - Varanda,Eliana Aparecida, AU - Bauab,Taís Maria, AU - da Rocha,Lúcia Regina Machado, AU - Di Stasi,Luis Cláudio, AU - Vilegas,Wagner, AU - Hiruma-Lima,Clélia Akiko, Y1 - 2009/10/13/ PY - 2009/06/05/received PY - 2009/09/29/revised PY - 2009/10/02/accepted PY - 2009/10/17/entrez PY - 2009/10/17/pubmed PY - 2010/9/9/medline SP - 508 EP - 14 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 127 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome. AIM OF THE STUDY: Based on ethnopharmacological data, methanolic extract from Qualea parviflora (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti-Helicobacter pylori activities. MATERIAL AND METHODS: The gastroprotective action of the extract was evaluated in rodent experimental models (HCl/ethanol, ethanol or NSAID). We also evaluated mutagenic effect (Ames assay), anti-Helicobacter pylori, anti-hemorrhagic action, analgesic and inflammatory effects (hot-plate test and carrageenin-induced hind paw edema) of methanolic extract from Qualea parviflora. RESULTS: QP (500 mg/kg, p.o.) was able to protect gastric mucosa against HCl/ethanol solution (77%), absolute ethanol (97%), and also against injurious effect of NSAID (36%). When QP was challenged with sulfhydryl depletor compound, the gastroprotective action of extract was abolished. QP treatment was able to maintain the GSH level and show a concentration-dependent inhibition effect on the lipid peroxidation. QP present anti-Helicobacter pylori effect (MIC=75 microg/mL), anti-hemorrhagic and antidiarrheal action but not present analgesic or anti-inflammatory effect. CONCLUSION: methanolic extract from Qualea parviflora had gastroprotective effect related to the increase of gastric mucosa defensive factors such PGE(2) levels and maintain the basal gastric glutathione levels. The methanolic extract also showed anti-Helicobacter pylori activity, anti-hemorrhagic effect and antioxidant action, but absence of analgesic, mutagenic and toxic effects, a profile that adds safety to its use. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19833186/Qualea_parviflora_Mart_:_an_integrative_study_to_validate_the_gastroprotective_antidiarrheal_antihemorragic_and_mutagenic_action_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00645-X DB - PRIME DP - Unbound Medicine ER -