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Human African trypanosomiasis.
Lancet. 2010 Jan 09; 375(9709):148-59.Lct

Abstract

Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible.

Authors+Show Affiliations

Swiss Tropical Institute, Basel, Switzerland. reto.brun@unibas.chNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19833383

Citation

Brun, Reto, et al. "Human African Trypanosomiasis." Lancet (London, England), vol. 375, no. 9709, 2010, pp. 148-59.
Brun R, Blum J, Chappuis F, et al. Human African trypanosomiasis. Lancet. 2010;375(9709):148-59.
Brun, R., Blum, J., Chappuis, F., & Burri, C. (2010). Human African trypanosomiasis. Lancet (London, England), 375(9709), 148-59. https://doi.org/10.1016/S0140-6736(09)60829-1
Brun R, et al. Human African Trypanosomiasis. Lancet. 2010 Jan 9;375(9709):148-59. PubMed PMID: 19833383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human African trypanosomiasis. AU - Brun,Reto, AU - Blum,Johannes, AU - Chappuis,Francois, AU - Burri,Christian, Y1 - 2009/10/14/ PY - 2009/10/17/entrez PY - 2009/10/17/pubmed PY - 2010/3/5/medline SP - 148 EP - 59 JF - Lancet (London, England) JO - Lancet VL - 375 IS - 9709 N2 - Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies. Almost all cases are due to Trypanosoma brucei gambiense, which is indigenous to west and central Africa. Prevalence is strongly dependent on control measures, which are often neglected during periods of political instability, thus leading to resurgence. With fewer than 12 000 cases of this disabling and fatal disease reported per year, trypanosomiasis belongs to the most neglected tropical diseases. The clinical presentation is complex, and diagnosis and treatment difficult. The available drugs are old, complicated to administer, and can cause severe adverse reactions. New diagnostic methods and safe and effective drugs are urgently needed. Vector control, to reduce the number of flies in existing foci, needs to be organised on a pan-African basis. WHO has stated that if national control programmes, international organisations, research institutes, and philanthropic partners engage in concerted action, elimination of this disease might even be possible. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/19833383/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(09)60829-1 DB - PRIME DP - Unbound Medicine ER -