Tags

Type your tag names separated by a space and hit enter

Cardiovascular risk factors and life events as antecedents of depressive symptoms in middle and early-old age: PATH Through Life Study.
Psychosom Med 2009; 71(9):937-43PM

Abstract

OBJECTIVE

To evaluate cardiovascular risk factors (CVRF) and life events (LE) as predictors of depressive symptoms in a mid-life and an early late-life cohort to determine whether they had independent or interacting effects, and whether there were age differences in the effects.

METHODS

Cohorts aged 40 to 44 years (n = 2530) and 60 to 64 years (n = 2551) at baseline (Wave 1) were followed up after 4 years (Wave 2) as part of the PATH Through Life Study based in Canberra and Queanbeyan, Australia. Cross-sectional analyses evaluated rates of CVRF and LE in depressed compared with nondepressed participants. Hierarchical generalized linear models were used to evaluate demographic variables, CVRF (diabetes, smoking, alcohol, body mass index, cholesterol medication, hypertension), LE, and Wave 1 depressive symptoms as predictors of depressive symptoms at Wave 2.

RESULTS

At baseline, those with high levels of depressive symptoms were more likely to report smoking, using cholesterol-lowering medications, hypertension, diabetes, past stroke, and higher body mass index. Predictors of depressive symptoms at Wave 2 in the cohort of 40- to 44-year-old persons included Wave 1 depressive symptoms, diabetes, and LE at Wave 2. In the cohort of 60- to 64-year-old individuals, Wave 1 depression, stroke, smoking, low education, and Wave 2 LE predicted depressive symptoms. There was no evidence of interactions between CVRF and LE.

CONCLUSIONS

LE and CVRF are independent sets of risk factors for depressive symptoms with different effects in the 40- to 44-year-old and 60- to 64-year-old cohorts. These findings have implications for preventative strategies for depression.

Authors+Show Affiliations

Centre for Mental Health Research, Australian National University, Canberra ACT 0200, Australia. kaarin.anstey@anu.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19834045

Citation

Anstey, Kaarin J., et al. "Cardiovascular Risk Factors and Life Events as Antecedents of Depressive Symptoms in Middle and Early-old Age: PATH Through Life Study." Psychosomatic Medicine, vol. 71, no. 9, 2009, pp. 937-43.
Anstey KJ, Burns R, Butterworth P, et al. Cardiovascular risk factors and life events as antecedents of depressive symptoms in middle and early-old age: PATH Through Life Study. Psychosom Med. 2009;71(9):937-43.
Anstey, K. J., Burns, R., Butterworth, P., Windsor, T. D., Christensen, H., & Sachdev, P. (2009). Cardiovascular risk factors and life events as antecedents of depressive symptoms in middle and early-old age: PATH Through Life Study. Psychosomatic Medicine, 71(9), pp. 937-43. doi:10.1097/PSY.0b013e3181beab60.
Anstey KJ, et al. Cardiovascular Risk Factors and Life Events as Antecedents of Depressive Symptoms in Middle and Early-old Age: PATH Through Life Study. Psychosom Med. 2009;71(9):937-43. PubMed PMID: 19834045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk factors and life events as antecedents of depressive symptoms in middle and early-old age: PATH Through Life Study. AU - Anstey,Kaarin J, AU - Burns,Richard, AU - Butterworth,Peter, AU - Windsor,Tim D, AU - Christensen,Helen, AU - Sachdev,Perminder, Y1 - 2009/10/15/ PY - 2009/10/17/entrez PY - 2009/10/17/pubmed PY - 2009/12/16/medline SP - 937 EP - 43 JF - Psychosomatic medicine JO - Psychosom Med VL - 71 IS - 9 N2 - OBJECTIVE: To evaluate cardiovascular risk factors (CVRF) and life events (LE) as predictors of depressive symptoms in a mid-life and an early late-life cohort to determine whether they had independent or interacting effects, and whether there were age differences in the effects. METHODS: Cohorts aged 40 to 44 years (n = 2530) and 60 to 64 years (n = 2551) at baseline (Wave 1) were followed up after 4 years (Wave 2) as part of the PATH Through Life Study based in Canberra and Queanbeyan, Australia. Cross-sectional analyses evaluated rates of CVRF and LE in depressed compared with nondepressed participants. Hierarchical generalized linear models were used to evaluate demographic variables, CVRF (diabetes, smoking, alcohol, body mass index, cholesterol medication, hypertension), LE, and Wave 1 depressive symptoms as predictors of depressive symptoms at Wave 2. RESULTS: At baseline, those with high levels of depressive symptoms were more likely to report smoking, using cholesterol-lowering medications, hypertension, diabetes, past stroke, and higher body mass index. Predictors of depressive symptoms at Wave 2 in the cohort of 40- to 44-year-old persons included Wave 1 depressive symptoms, diabetes, and LE at Wave 2. In the cohort of 60- to 64-year-old individuals, Wave 1 depression, stroke, smoking, low education, and Wave 2 LE predicted depressive symptoms. There was no evidence of interactions between CVRF and LE. CONCLUSIONS: LE and CVRF are independent sets of risk factors for depressive symptoms with different effects in the 40- to 44-year-old and 60- to 64-year-old cohorts. These findings have implications for preventative strategies for depression. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/19834045/Cardiovascular_risk_factors_and_life_events_as_antecedents_of_depressive_symptoms_in_middle_and_early_old_age:_PATH_Through_Life_Study_ L2 - http://Insights.ovid.com/pubmed?pmid=19834045 DB - PRIME DP - Unbound Medicine ER -