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Learning, retrieval, and recognition are compromised in aMCI and mild AD: are distinct episodic memory processes mediated by the same anatomical structures?
J Int Neuropsychol Soc. 2010 Jan; 16(1):205-9.JI

Abstract

Performance of different episodic memory processes in patients with amnestic mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD) and their anatomical correlates are not completely understood. We evaluated the performance of 48 subjects (17 with aMCI, 15 with mild AD, and 16 controls) on the Rey Auditory Verbal Learning Test (RAVLT). A brain MRI voxel-based morphometry (VBM) analysis was run with the aim of evaluating the correlations between RAVLT and gray matter density. All memory processes were compromised in aMCI and mild AD. Also, the same cerebral structures were involved in all RAVLT stages. Learning and delayed recall were more related to the medial prefrontal cortex and hippocampi, whereas recognition was more related to the thalamic nuclei and caudate nucleus, particularly in the left side. Our findings suggest that these structures may act as a complex functional system and are involved in the acquisition of new information.

Authors+Show Affiliations

Neuropsychology and Neurolinguistics Unit, Department of Neurology, Medical Sciences School, University of Campinas (UNICAMP), Campinas/SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19835661

Citation

Balthazar, Marcio L F., et al. "Learning, Retrieval, and Recognition Are Compromised in aMCI and Mild AD: Are Distinct Episodic Memory Processes Mediated By the Same Anatomical Structures?" Journal of the International Neuropsychological Society : JINS, vol. 16, no. 1, 2010, pp. 205-9.
Balthazar ML, Yasuda CL, Cendes F, et al. Learning, retrieval, and recognition are compromised in aMCI and mild AD: are distinct episodic memory processes mediated by the same anatomical structures? J Int Neuropsychol Soc. 2010;16(1):205-9.
Balthazar, M. L., Yasuda, C. L., Cendes, F., & Damasceno, B. P. (2010). Learning, retrieval, and recognition are compromised in aMCI and mild AD: are distinct episodic memory processes mediated by the same anatomical structures? Journal of the International Neuropsychological Society : JINS, 16(1), 205-9. https://doi.org/10.1017/S1355617709990956
Balthazar ML, et al. Learning, Retrieval, and Recognition Are Compromised in aMCI and Mild AD: Are Distinct Episodic Memory Processes Mediated By the Same Anatomical Structures. J Int Neuropsychol Soc. 2010;16(1):205-9. PubMed PMID: 19835661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Learning, retrieval, and recognition are compromised in aMCI and mild AD: are distinct episodic memory processes mediated by the same anatomical structures? AU - Balthazar,Marcio L F, AU - Yasuda,Clarissa L, AU - Cendes,Fernando, AU - Damasceno,Benito P, Y1 - 2009/10/19/ PY - 2009/10/20/entrez PY - 2009/10/20/pubmed PY - 2010/3/3/medline SP - 205 EP - 9 JF - Journal of the International Neuropsychological Society : JINS JO - J Int Neuropsychol Soc VL - 16 IS - 1 N2 - Performance of different episodic memory processes in patients with amnestic mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD) and their anatomical correlates are not completely understood. We evaluated the performance of 48 subjects (17 with aMCI, 15 with mild AD, and 16 controls) on the Rey Auditory Verbal Learning Test (RAVLT). A brain MRI voxel-based morphometry (VBM) analysis was run with the aim of evaluating the correlations between RAVLT and gray matter density. All memory processes were compromised in aMCI and mild AD. Also, the same cerebral structures were involved in all RAVLT stages. Learning and delayed recall were more related to the medial prefrontal cortex and hippocampi, whereas recognition was more related to the thalamic nuclei and caudate nucleus, particularly in the left side. Our findings suggest that these structures may act as a complex functional system and are involved in the acquisition of new information. SN - 1469-7661 UR - https://www.unboundmedicine.com/medline/citation/19835661/Learning_retrieval_and_recognition_are_compromised_in_aMCI_and_mild_AD:_are_distinct_episodic_memory_processes_mediated_by_the_same_anatomical_structures L2 - https://www.cambridge.org/core/product/identifier/S1355617709990956/type/journal_article DB - PRIME DP - Unbound Medicine ER -