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Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleasant pictures: a high density ERP study.
Neuroimage. 2010 Feb 01; 49(3):2800-6.N

Abstract

Evidence from both animal and human research suggests that the formation of emotional memories is triggered by the beta-adrenergic system. To confirm whether modulation of central beta-adrenergic transmission is specifically involved in the neural signature of memory performance, the pre-encoding effect of propranolol (80 mg) on event-related potentials (ERPs) was measured in a placebo-controlled, double-blind, parallel-group study in 46 male healthy subjects using high density EEG and source imaging analysis during encoding and retrieval (after 1 week) of IAPS pictures of unpleasant, neutral and pleasant contents; for recognition 90 old pictures were randomly mixed with 90 new pictures. During retrieval correctly remembered old pictures elicited a significantly larger positive voltage change over the centro-parietal cortex than new pictures. Propranolol significantly reduced this old/new difference of the mean ERP amplitudes (500-800 ms) for unpleasant but not for neutral and pleasant memories. This effect correlated with salivary alpha-amylase activity, a surrogate for central adrenergic stimulation. In conclusion, propranolol selectively blocked the neural signature of unpleasant memories by mechanisms in which the parietal cortex seems to be specifically involved.

Authors+Show Affiliations

Department of Biological and Clinical Psychology, University of Greifswald, Franz-Mehring-Strasse 47, 17487 Greifswald, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19837180

Citation

Weymar, Mathias, et al. "Propranolol Selectively Blocks the Enhanced Parietal Old/new Effect During Long-term Recollection of Unpleasant Pictures: a High Density ERP Study." NeuroImage, vol. 49, no. 3, 2010, pp. 2800-6.
Weymar M, Löw A, Modess C, et al. Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleasant pictures: a high density ERP study. Neuroimage. 2010;49(3):2800-6.
Weymar, M., Löw, A., Modess, C., Engel, G., Gründling, M., Petersmann, A., Siegmund, W., & Hamm, A. O. (2010). Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleasant pictures: a high density ERP study. NeuroImage, 49(3), 2800-6. https://doi.org/10.1016/j.neuroimage.2009.10.025
Weymar M, et al. Propranolol Selectively Blocks the Enhanced Parietal Old/new Effect During Long-term Recollection of Unpleasant Pictures: a High Density ERP Study. Neuroimage. 2010 Feb 1;49(3):2800-6. PubMed PMID: 19837180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propranolol selectively blocks the enhanced parietal old/new effect during long-term recollection of unpleasant pictures: a high density ERP study. AU - Weymar,Mathias, AU - Löw,Andreas, AU - Modess,Christiane, AU - Engel,Georg, AU - Gründling,Matthias, AU - Petersmann,Astrid, AU - Siegmund,Werner, AU - Hamm,Alfons O, Y1 - 2009/10/23/ PY - 2009/07/23/received PY - 2009/10/07/revised PY - 2009/10/09/accepted PY - 2009/10/20/entrez PY - 2009/10/20/pubmed PY - 2010/4/14/medline SP - 2800 EP - 6 JF - NeuroImage JO - Neuroimage VL - 49 IS - 3 N2 - Evidence from both animal and human research suggests that the formation of emotional memories is triggered by the beta-adrenergic system. To confirm whether modulation of central beta-adrenergic transmission is specifically involved in the neural signature of memory performance, the pre-encoding effect of propranolol (80 mg) on event-related potentials (ERPs) was measured in a placebo-controlled, double-blind, parallel-group study in 46 male healthy subjects using high density EEG and source imaging analysis during encoding and retrieval (after 1 week) of IAPS pictures of unpleasant, neutral and pleasant contents; for recognition 90 old pictures were randomly mixed with 90 new pictures. During retrieval correctly remembered old pictures elicited a significantly larger positive voltage change over the centro-parietal cortex than new pictures. Propranolol significantly reduced this old/new difference of the mean ERP amplitudes (500-800 ms) for unpleasant but not for neutral and pleasant memories. This effect correlated with salivary alpha-amylase activity, a surrogate for central adrenergic stimulation. In conclusion, propranolol selectively blocked the neural signature of unpleasant memories by mechanisms in which the parietal cortex seems to be specifically involved. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/19837180/Propranolol_selectively_blocks_the_enhanced_parietal_old/new_effect_during_long_term_recollection_of_unpleasant_pictures:_a_high_density_ERP_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(09)01096-9 DB - PRIME DP - Unbound Medicine ER -