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Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives.
Eur J Med Chem. 2010 Jan; 45(1):85-9.EJ

Abstract

A series of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives have been synthesized by reaction of 7-amino-4-methyl-benzopyran-2-one (1) with an appropriate substituted aldehydes to obtain various Schiff bases (3a-k) which on treatment with thioglycolic acid afforded the title compounds (4a-k). Purity of the compounds has been confirmed by TLC. Structure of these compounds were established on the bases IR, 1H NMR, 13C NMR and Mass spectral data. Schiff bases and title compounds were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that compounds 3d, 3f, 4d, 4f and 4i (100 microg/ml) exhibited good antibacterial and antifungal activity as that of standard antibiotics Ciprofloxacin and Griseofulvin.

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Authors+Show Affiliations

Ronad PM
Department of Pharmaceutical chemistry, KLE's College of Pharmacy, Vidyanagar, Hubli-580031, Karnataka, India. ronad_p@rediffmail.com
Noolvi MN
No affiliation info available
Sapkal S
No affiliation info available
Dharbhamulla S
No affiliation info available
Maddi VS
No affiliation info available

MeSH

Anti-Infective AgentsBacteriaCoumarinsFungiSpectrum AnalysisThiazolidines

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19837487

Citation

Ronad, Pradeepkumar M., et al. "Synthesis and Antimicrobial Activity of 7-(2-substituted Phenylthiazolidinyl)-benzopyran-2-one Derivatives." European Journal of Medicinal Chemistry, vol. 45, no. 1, 2010, pp. 85-9.
Ronad PM, Noolvi MN, Sapkal S, et al. Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives. Eur J Med Chem. 2010;45(1):85-9.
Ronad, P. M., Noolvi, M. N., Sapkal, S., Dharbhamulla, S., & Maddi, V. S. (2010). Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives. European Journal of Medicinal Chemistry, 45(1), 85-9. https://doi.org/10.1016/j.ejmech.2009.09.028
Ronad PM, et al. Synthesis and Antimicrobial Activity of 7-(2-substituted Phenylthiazolidinyl)-benzopyran-2-one Derivatives. Eur J Med Chem. 2010;45(1):85-9. PubMed PMID: 19837487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and antimicrobial activity of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives. AU - Ronad,Pradeepkumar M, AU - Noolvi,Malleshappa N, AU - Sapkal,Sheetal, AU - Dharbhamulla,Satyanarayana, AU - Maddi,Veeresh S, Y1 - 2009/09/23/ PY - 2008/07/24/received PY - 2009/08/04/revised PY - 2009/09/17/accepted PY - 2009/10/20/entrez PY - 2009/10/20/pubmed PY - 2010/4/30/medline SP - 85 EP - 9 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 45 IS - 1 N2 - A series of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives have been synthesized by reaction of 7-amino-4-methyl-benzopyran-2-one (1) with an appropriate substituted aldehydes to obtain various Schiff bases (3a-k) which on treatment with thioglycolic acid afforded the title compounds (4a-k). Purity of the compounds has been confirmed by TLC. Structure of these compounds were established on the bases IR, 1H NMR, 13C NMR and Mass spectral data. Schiff bases and title compounds were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that compounds 3d, 3f, 4d, 4f and 4i (100 microg/ml) exhibited good antibacterial and antifungal activity as that of standard antibiotics Ciprofloxacin and Griseofulvin. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/19837487/Synthesis_and_antimicrobial_activity_of_7__2_substituted_phenylthiazolidinyl__benzopyran_2_one_derivatives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(09)00460-7 DB - PRIME DP - Unbound Medicine ER -