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Clinical and pathologic predictors of Gleason sum upgrading in patients after radical prostatectomy: results from a single institution series.
Urol Oncol. 2011 Sep-Oct; 29(5):508-14.UO

Abstract

OBJECTIVES

Preoperative Gleason scores (GSs) are often upgraded after pathologic examination of the prostate following radical prostatectomy (RP). There have been disparate reports of the impact of different factors as predictors of GS upgrading after RP. We sought to study the robustness of frequently reported predictors in an unselected single institution cohort.

PATIENTS AND METHODS

A total of 684 patients with biopsy-proven prostate cancer treated with RP between 2004 and 2007 were included in the study. The association between clinical and pathologic parameters and GS upgrading was retrospectively evaluated. Logistic regression analysis was used to identify predictors of pathologic grading changes. Likelihood of upgrading was compared between tertile groups for prostate volume and prostate-specific antigen (PSA) density using χ(2) analysis and multivariate logistic regression. Pathologic outcomes were compared between cases with and without GS upgrading.

RESULTS

The overall mean age was 64.3 years, with median PSA level of 7.04 ng/ml. Overall, 203 cases (29.7%) were upgraded, whereas 481 patients (70.3%) were downgraded or had identical biopsy and pathologic GS after RP. Patients with prostate volume of <31 g were upgraded in 32.6% of the cases compared with 21.9% in patients with prostate volume of >45 g (P = 0.020). On multivariate analysis preoperative PSA (P < 0.0001), prostate volume (P < 0.0001), and PSA density (P < 0.0001) were predictive of Gleason sum upgrading. Upgraded patients were more likely to have extracapsular extension, seminal vesicle invasion, positive surgical margins, and lymphonodular invasion at RP (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively).

CONCLUSIONS

Smaller prostate volume and higher PSA level are associated with clinically significant upgrading of GS. PSA density as a function of both is a significant predictor of GS upgrading in low- and high-risk patients. This may be of relevance in the pretreatment risk assessment of prostate cancer patients.

Authors+Show Affiliations

Department of Urology, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany. Derya.Tilki@med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19837614

Citation

Tilki, Derya, et al. "Clinical and Pathologic Predictors of Gleason Sum Upgrading in Patients After Radical Prostatectomy: Results From a Single Institution Series." Urologic Oncology, vol. 29, no. 5, 2011, pp. 508-14.
Tilki D, Schlenker B, John M, et al. Clinical and pathologic predictors of Gleason sum upgrading in patients after radical prostatectomy: results from a single institution series. Urol Oncol. 2011;29(5):508-14.
Tilki, D., Schlenker, B., John, M., Buchner, A., Stanislaus, P., Gratzke, C., Karl, A., Tan, G. Y., Ergün, S., Tewari, A. K., Stief, C. G., Seitz, M., & Reich, O. (2011). Clinical and pathologic predictors of Gleason sum upgrading in patients after radical prostatectomy: results from a single institution series. Urologic Oncology, 29(5), 508-14. https://doi.org/10.1016/j.urolonc.2009.07.003
Tilki D, et al. Clinical and Pathologic Predictors of Gleason Sum Upgrading in Patients After Radical Prostatectomy: Results From a Single Institution Series. Urol Oncol. 2011 Sep-Oct;29(5):508-14. PubMed PMID: 19837614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and pathologic predictors of Gleason sum upgrading in patients after radical prostatectomy: results from a single institution series. AU - Tilki,Derya, AU - Schlenker,Boris, AU - John,Majnu, AU - Buchner,Alexander, AU - Stanislaus,Peter, AU - Gratzke,Christian, AU - Karl,Alexander, AU - Tan,Gerald Y, AU - Ergün,Süleyman, AU - Tewari,Ashutosh K, AU - Stief,Christian G, AU - Seitz,Michael, AU - Reich,Oliver, Y1 - 2009/10/17/ PY - 2009/06/07/received PY - 2009/07/07/revised PY - 2009/07/07/accepted PY - 2009/10/20/entrez PY - 2009/10/20/pubmed PY - 2012/2/3/medline SP - 508 EP - 14 JF - Urologic oncology JO - Urol Oncol VL - 29 IS - 5 N2 - OBJECTIVES: Preoperative Gleason scores (GSs) are often upgraded after pathologic examination of the prostate following radical prostatectomy (RP). There have been disparate reports of the impact of different factors as predictors of GS upgrading after RP. We sought to study the robustness of frequently reported predictors in an unselected single institution cohort. PATIENTS AND METHODS: A total of 684 patients with biopsy-proven prostate cancer treated with RP between 2004 and 2007 were included in the study. The association between clinical and pathologic parameters and GS upgrading was retrospectively evaluated. Logistic regression analysis was used to identify predictors of pathologic grading changes. Likelihood of upgrading was compared between tertile groups for prostate volume and prostate-specific antigen (PSA) density using χ(2) analysis and multivariate logistic regression. Pathologic outcomes were compared between cases with and without GS upgrading. RESULTS: The overall mean age was 64.3 years, with median PSA level of 7.04 ng/ml. Overall, 203 cases (29.7%) were upgraded, whereas 481 patients (70.3%) were downgraded or had identical biopsy and pathologic GS after RP. Patients with prostate volume of <31 g were upgraded in 32.6% of the cases compared with 21.9% in patients with prostate volume of >45 g (P = 0.020). On multivariate analysis preoperative PSA (P < 0.0001), prostate volume (P < 0.0001), and PSA density (P < 0.0001) were predictive of Gleason sum upgrading. Upgraded patients were more likely to have extracapsular extension, seminal vesicle invasion, positive surgical margins, and lymphonodular invasion at RP (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, respectively). CONCLUSIONS: Smaller prostate volume and higher PSA level are associated with clinically significant upgrading of GS. PSA density as a function of both is a significant predictor of GS upgrading in low- and high-risk patients. This may be of relevance in the pretreatment risk assessment of prostate cancer patients. SN - 1873-2496 UR - https://www.unboundmedicine.com/medline/citation/19837614/Clinical_and_pathologic_predictors_of_Gleason_sum_upgrading_in_patients_after_radical_prostatectomy:_results_from_a_single_institution_series_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-1439(09)00204-X DB - PRIME DP - Unbound Medicine ER -