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Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan.
Nutr Cancer 2009; 61(4):447-56NC

Abstract

We investigated associations among intake of folate, vitamin B2, vitamin B6, vitamin B12, and polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) genes and breast cancer risk in a Japanese population. A hospital based, case-control study was conducted in Nagano Prefecture, Japan, in 388 pairs of patients with histologically confirmed invasive breast cancer and age- and area-matched controls selected from medical checkup examinees. Energy-adjusted intakes of folate and other B vitamins were derived from a validated food frequency questionnaire. Genotyping was completed for MTHFR (C677T and A1298T) and MTR (A2756G). Odds ratios and 95% confidence intervals were calculated by the conditional logistical regression model. Median dietary folate intake (microg/day) in the control group was 438.2 (interquartile range: 354.9-542.9). Neither dietary intake of folate, vitamin B2, vitamin B6, or vitamin B12 nor polymorphisms of MTHFR or MTR genes were significantly associated with breast cancer risk. Further, no significant interaction was found among nutrients, polymorphisms, and breast cancer risk. Associations of nutrients with breast cancer risk did not differ by hormone receptors status. We conclude that dietary intake of folate and related B vitamins and genotypes of MTHFR or MTR have no overall association with breast cancer risk in Japanese women.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Ma E
    National Cancer Center, Tokyo, Japan.
    Iwasaki M
    No affiliation info available
    Kobayashi M
    No affiliation info available
    Kasuga Y
    No affiliation info available
    Yokoyama S
    No affiliation info available
    Onuma H
    No affiliation info available
    Nishimura H
    No affiliation info available
    Kusama R
    No affiliation info available
    Tsugane S
    No affiliation info available

    MeSH

    5,10-Methylenetetrahydrofolate Reductase (FADH2)5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAdultAgedBody Mass IndexBreast NeoplasmsCase-Control StudiesChi-Square DistributionConfidence IntervalsDietDiet SurveysEnergy IntakeFemaleFolic AcidHumansJapanMatched-Pair AnalysisMiddle AgedMotor ActivityNeoplasm InvasivenessOdds RatioPolymorphism, GeneticReceptors, EstrogenReceptors, ProgesteroneRiboflavinRisk FactorsSurveys and QuestionnairesVitamin B 12Vitamin B 6Vitamin B ComplexYoung Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19838916

    Citation

    Ma, Enbo, et al. "Dietary Intake of Folate, Vitamin B2, Vitamin B6, Vitamin B12, Genetic Polymorphism of Related Enzymes, and Risk of Breast Cancer: a Case-control Study in Japan." Nutrition and Cancer, vol. 61, no. 4, 2009, pp. 447-56.
    Ma E, Iwasaki M, Kobayashi M, et al. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutr Cancer. 2009;61(4):447-56.
    Ma, E., Iwasaki, M., Kobayashi, M., Kasuga, Y., Yokoyama, S., Onuma, H., ... Tsugane, S. (2009). Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. Nutrition and Cancer, 61(4), pp. 447-56. doi:10.1080/01635580802610123.
    Ma E, et al. Dietary Intake of Folate, Vitamin B2, Vitamin B6, Vitamin B12, Genetic Polymorphism of Related Enzymes, and Risk of Breast Cancer: a Case-control Study in Japan. Nutr Cancer. 2009;61(4):447-56. PubMed PMID: 19838916.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Japan. AU - Ma,Enbo, AU - Iwasaki,Motoki, AU - Kobayashi,Minatsu, AU - Kasuga,Yoshio, AU - Yokoyama,Shiro, AU - Onuma,Hiroshi, AU - Nishimura,Hideki, AU - Kusama,Ritsu, AU - Tsugane,Shoichiro, PY - 2009/10/20/entrez PY - 2009/10/20/pubmed PY - 2009/12/16/medline SP - 447 EP - 56 JF - Nutrition and cancer JO - Nutr Cancer VL - 61 IS - 4 N2 - We investigated associations among intake of folate, vitamin B2, vitamin B6, vitamin B12, and polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) genes and breast cancer risk in a Japanese population. A hospital based, case-control study was conducted in Nagano Prefecture, Japan, in 388 pairs of patients with histologically confirmed invasive breast cancer and age- and area-matched controls selected from medical checkup examinees. Energy-adjusted intakes of folate and other B vitamins were derived from a validated food frequency questionnaire. Genotyping was completed for MTHFR (C677T and A1298T) and MTR (A2756G). Odds ratios and 95% confidence intervals were calculated by the conditional logistical regression model. Median dietary folate intake (microg/day) in the control group was 438.2 (interquartile range: 354.9-542.9). Neither dietary intake of folate, vitamin B2, vitamin B6, or vitamin B12 nor polymorphisms of MTHFR or MTR genes were significantly associated with breast cancer risk. Further, no significant interaction was found among nutrients, polymorphisms, and breast cancer risk. Associations of nutrients with breast cancer risk did not differ by hormone receptors status. We conclude that dietary intake of folate and related B vitamins and genotypes of MTHFR or MTR have no overall association with breast cancer risk in Japanese women. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/19838916/Dietary_intake_of_folate_vitamin_B2_vitamin_B6_vitamin_B12_genetic_polymorphism_of_related_enzymes_and_risk_of_breast_cancer:_a_case_control_study_in_Japan_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580802610123 DB - PRIME DP - Unbound Medicine ER -