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Physical activity, diet, and pancreatic cancer: a population-based, case-control study in Minnesota.

Abstract

Although mounting evidence suggests that insulin resistance is involved in pancreatic carcinogenesis, few epidemiologic studies have comprehensively investigated the role of lifestyle factors influencing this metabolic disorder in the etiology of pancreatic cancer. We sought to examine this problem in a case-control study conducted in 1994-1998 in Minnesota. Cases (n = 186), aged 20 yr or older, were ascertained from all hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic; from the latter, only cases residing in the Upper Midwest of the United States were recruited. Controls (n = 554) were randomly selected from the general population and frequency matched to cases by age (within 5 yr) and sex. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression. After adjustment for confounders, physical activity was associated with a reduced risk, but this protective effect was confined to light activity and moderate activity only (OR = 0.55, 95% CI = 0.30-0.97, P(trend) = 0.038 and OR = 0.51, 95% CI = 0.28-0.93, P(trend) = 0.07, for highest vs. lowest quartile, respectively). An increased risk was found for dietary intakes of energy and fat but was statistically significant for saturated and polyunsaturated fat only. Of note, no appreciable difference in the magnitude of the associations existed between saturated, monounsaturated, and polyunsaturated fat. Compared with individuals in the lowest quartile of fiber intake, the risk was approximately halved for those in the third (OR = 0.49, 95% CI = 0.26-0.94) and the highest quartile (OR = 0.52, 95% CI = 0.21-1.30). Our study lends support to the hypothesis that dietary and other lifestyle factors influencing insulin resistance modulate pancreatic cancer risk.

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  • Authors+Show Affiliations

    ,

    University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. zhangjianjun@uams.edu

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    Source

    Nutrition and cancer 61:4 2009 pg 457-65

    MeSH

    Adult
    Aged
    Case-Control Studies
    Confidence Intervals
    Diet
    Diet Surveys
    Dietary Fats
    Dietary Fiber
    Energy Intake
    Female
    Humans
    Insulin Resistance
    Male
    Middle Aged
    Minnesota
    Motor Activity
    Odds Ratio
    Pancreas, Exocrine
    Pancreatic Neoplasms
    Probability
    Surveys and Questionnaires
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19838917

    Citation

    Zhang, Jianjun, et al. "Physical Activity, Diet, and Pancreatic Cancer: a Population-based, Case-control Study in Minnesota." Nutrition and Cancer, vol. 61, no. 4, 2009, pp. 457-65.
    Zhang J, Dhakal IB, Gross MD, et al. Physical activity, diet, and pancreatic cancer: a population-based, case-control study in Minnesota. Nutr Cancer. 2009;61(4):457-65.
    Zhang, J., Dhakal, I. B., Gross, M. D., Lang, N. P., Kadlubar, F. F., Harnack, L. J., & Anderson, K. E. (2009). Physical activity, diet, and pancreatic cancer: a population-based, case-control study in Minnesota. Nutrition and Cancer, 61(4), pp. 457-65. doi:10.1080/01635580902718941.
    Zhang J, et al. Physical Activity, Diet, and Pancreatic Cancer: a Population-based, Case-control Study in Minnesota. Nutr Cancer. 2009;61(4):457-65. PubMed PMID: 19838917.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Physical activity, diet, and pancreatic cancer: a population-based, case-control study in Minnesota. AU - Zhang,Jianjun, AU - Dhakal,Ishwori B, AU - Gross,Myron D, AU - Lang,Nicholas P, AU - Kadlubar,Fred F, AU - Harnack,Lisa J, AU - Anderson,Kristin E, PY - 2009/10/20/entrez PY - 2009/10/20/pubmed PY - 2009/12/16/medline SP - 457 EP - 65 JF - Nutrition and cancer JO - Nutr Cancer VL - 61 IS - 4 N2 - Although mounting evidence suggests that insulin resistance is involved in pancreatic carcinogenesis, few epidemiologic studies have comprehensively investigated the role of lifestyle factors influencing this metabolic disorder in the etiology of pancreatic cancer. We sought to examine this problem in a case-control study conducted in 1994-1998 in Minnesota. Cases (n = 186), aged 20 yr or older, were ascertained from all hospitals in the metropolitan area of the Twin Cities and the Mayo Clinic; from the latter, only cases residing in the Upper Midwest of the United States were recruited. Controls (n = 554) were randomly selected from the general population and frequency matched to cases by age (within 5 yr) and sex. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression. After adjustment for confounders, physical activity was associated with a reduced risk, but this protective effect was confined to light activity and moderate activity only (OR = 0.55, 95% CI = 0.30-0.97, P(trend) = 0.038 and OR = 0.51, 95% CI = 0.28-0.93, P(trend) = 0.07, for highest vs. lowest quartile, respectively). An increased risk was found for dietary intakes of energy and fat but was statistically significant for saturated and polyunsaturated fat only. Of note, no appreciable difference in the magnitude of the associations existed between saturated, monounsaturated, and polyunsaturated fat. Compared with individuals in the lowest quartile of fiber intake, the risk was approximately halved for those in the third (OR = 0.49, 95% CI = 0.26-0.94) and the highest quartile (OR = 0.52, 95% CI = 0.21-1.30). Our study lends support to the hypothesis that dietary and other lifestyle factors influencing insulin resistance modulate pancreatic cancer risk. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/19838917/Physical_activity_diet_and_pancreatic_cancer:_a_population_based_case_control_study_in_Minnesota_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580902718941 DB - PRIME DP - Unbound Medicine ER -