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Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring.
Int J Cancer. 2010 Jun 01; 126(11):2690-9.IJ

Abstract

The Australian Study of Causes of Acute Lymphoblastic Leukemia in Children (Aus-ALL) was designed to test the hypothesis, raised by a previous Western Australian study, that maternal folic acid supplementation during pregnancy might reduce the risk of childhood acute lymphoblastic leukemia (ALL). Aus-ALL was a national, population-based, multicenter case-control study that prospectively recruited 416 cases and 1,361 controls between 2003 and 2007. Detailed information was collected about maternal use of folic acid and other vitamin supplements before and during the index pregnancy. Data were analyzed using logistic regression, adjusting for matching factors and potential confounders. A meta-analysis with the results of previous studies of folic acid supplementation was also conducted. We found weak evidence of a protective effect of maternal folate supplementation before pregnancy against risk of childhood ALL, but no evidence for a protective effect of its use during pregnancy. A meta-analysis including this and 2 other studies, but not the study that raised the hypothesis, also found little evidence that folate supplementation during pregnancy protects against ALL: the summary odds ratios (ORs) for folate supplementation were 1.06 [95% confidence interval (CI): 0.77-1.48] with reference to no folate supplementation and 1.02 (95% CI: 0.86-1.20) with reference to no vitamin supplementation. For vitamin supplementation in general, the summary OR from a meta-analysis of 5 studies-including Aus-ALL-was 0.83 (95% CI: 0.73-0.94). Vitamin supplementation in pregnancy may protect against childhood ALL, but this effect is unlikely to be large or, if real, specifically due to folate.

Authors+Show Affiliations

Telethon Institute for Child Health Research, Centre for Child Health Research, West Perth, Western Australia 6872, Australia. lizm@ichr.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19839053

Citation

Milne, Elizabeth, et al. "Maternal Folate and Other Vitamin Supplementation During Pregnancy and Risk of Acute Lymphoblastic Leukemia in the Offspring." International Journal of Cancer, vol. 126, no. 11, 2010, pp. 2690-9.
Milne E, Royle JA, Miller M, et al. Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring. Int J Cancer. 2010;126(11):2690-9.
Milne, E., Royle, J. A., Miller, M., Bower, C., de Klerk, N. H., Bailey, H. D., van Bockxmeer, F., Attia, J., Scott, R. J., Norris, M. D., Haber, M., Thompson, J. R., Fritschi, L., Marshall, G. M., & Armstrong, B. K. (2010). Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring. International Journal of Cancer, 126(11), 2690-9. https://doi.org/10.1002/ijc.24969
Milne E, et al. Maternal Folate and Other Vitamin Supplementation During Pregnancy and Risk of Acute Lymphoblastic Leukemia in the Offspring. Int J Cancer. 2010 Jun 1;126(11):2690-9. PubMed PMID: 19839053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring. AU - Milne,Elizabeth, AU - Royle,Jill A, AU - Miller,Margaret, AU - Bower,Carol, AU - de Klerk,Nicholas H, AU - Bailey,Helen D, AU - van Bockxmeer,Frank, AU - Attia,John, AU - Scott,Rodney J, AU - Norris,Murray D, AU - Haber,Michelle, AU - Thompson,Judith R, AU - Fritschi,Lin, AU - Marshall,Glenn M, AU - Armstrong,Bruce K, PY - 2009/10/20/entrez PY - 2009/10/20/pubmed PY - 2010/4/24/medline SP - 2690 EP - 9 JF - International journal of cancer JO - Int J Cancer VL - 126 IS - 11 N2 - The Australian Study of Causes of Acute Lymphoblastic Leukemia in Children (Aus-ALL) was designed to test the hypothesis, raised by a previous Western Australian study, that maternal folic acid supplementation during pregnancy might reduce the risk of childhood acute lymphoblastic leukemia (ALL). Aus-ALL was a national, population-based, multicenter case-control study that prospectively recruited 416 cases and 1,361 controls between 2003 and 2007. Detailed information was collected about maternal use of folic acid and other vitamin supplements before and during the index pregnancy. Data were analyzed using logistic regression, adjusting for matching factors and potential confounders. A meta-analysis with the results of previous studies of folic acid supplementation was also conducted. We found weak evidence of a protective effect of maternal folate supplementation before pregnancy against risk of childhood ALL, but no evidence for a protective effect of its use during pregnancy. A meta-analysis including this and 2 other studies, but not the study that raised the hypothesis, also found little evidence that folate supplementation during pregnancy protects against ALL: the summary odds ratios (ORs) for folate supplementation were 1.06 [95% confidence interval (CI): 0.77-1.48] with reference to no folate supplementation and 1.02 (95% CI: 0.86-1.20) with reference to no vitamin supplementation. For vitamin supplementation in general, the summary OR from a meta-analysis of 5 studies-including Aus-ALL-was 0.83 (95% CI: 0.73-0.94). Vitamin supplementation in pregnancy may protect against childhood ALL, but this effect is unlikely to be large or, if real, specifically due to folate. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/19839053/Maternal_folate_and_other_vitamin_supplementation_during_pregnancy_and_risk_of_acute_lymphoblastic_leukemia_in_the_offspring_ L2 - https://doi.org/10.1002/ijc.24969 DB - PRIME DP - Unbound Medicine ER -