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Evaluation of a drug with wax-like properties as a melt binder.
Acta Pharm. 2006 Dec; 56(4):451-61.AP

Abstract

The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr's index, Hausner's ratio, crushing strength, percentage fines, Heckel plot study and tensile strength. To check the binder distribution during melt granulation, the content uniformity was determined. To check changes in the physical state of ibuprofen, XRPD, DSC and FTIR studies were carried out. The present study underlines the fact that ibuprofen may be adopted as a binder in ibuprofen formulations using the melt granulation technique.

Authors+Show Affiliations

Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19839137

Citation

Dhumal, Ravindra S., et al. "Evaluation of a Drug With Wax-like Properties as a Melt Binder." Acta Pharmaceutica (Zagreb, Croatia), vol. 56, no. 4, 2006, pp. 451-61.
Dhumal RS, Shimpi SL, Chauhan B, et al. Evaluation of a drug with wax-like properties as a melt binder. Acta Pharm. 2006;56(4):451-61.
Dhumal, R. S., Shimpi, S. L., Chauhan, B., Mahadik, K. R., & Paradkar, A. (2006). Evaluation of a drug with wax-like properties as a melt binder. Acta Pharmaceutica (Zagreb, Croatia), 56(4), 451-61.
Dhumal RS, et al. Evaluation of a Drug With Wax-like Properties as a Melt Binder. Acta Pharm. 2006;56(4):451-61. PubMed PMID: 19839137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a drug with wax-like properties as a melt binder. AU - Dhumal,Ravindra S, AU - Shimpi,Shamkant L, AU - Chauhan,Bhaskar, AU - Mahadik,Kakasahib R, AU - Paradkar,Anant, PY - 2009/10/21/entrez PY - 2006/12/1/pubmed PY - 2009/12/16/medline SP - 451 EP - 61 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 56 IS - 4 N2 - The study investigates ibuprofen with wax-like properties as a multifunctional agent (as an active component and as a melt binder). Binding efficiency was compared with granules prepared by wet granulation using polyvinylpyrollidone (PVP K-30) as a binder for micromeritic, physical and mechanical properties such as angle of repose, particle size distribution Carr's index, Hausner's ratio, crushing strength, percentage fines, Heckel plot study and tensile strength. To check the binder distribution during melt granulation, the content uniformity was determined. To check changes in the physical state of ibuprofen, XRPD, DSC and FTIR studies were carried out. The present study underlines the fact that ibuprofen may be adopted as a binder in ibuprofen formulations using the melt granulation technique. SN - 1330-0075 UR - https://www.unboundmedicine.com/medline/citation/19839137/Evaluation_of_a_drug_with_wax_like_properties_as_a_melt_binder_ DB - PRIME DP - Unbound Medicine ER -