Tags

Type your tag names separated by a space and hit enter

Amphotericin B microspheres: a therapeutic approach to minimize toxicity while maintaining antifungal efficacy.
J Microencapsul. 2009 Nov; 26(7):580-7.JM

Abstract

Amphotericin B microsphere formulations with and without addition of polyethylene glycol 2000 in cross-linked bovine serum albumin were prepared. Amphotericin B microspheres were characterized for particle size (<5 microm), zeta potential (approximately 30 mV) and drug interaction by DSC and FTIR and were found to be stable formulations. Drug release profiles for these microspheres revealed that the release was primarily by diffusion. In vitro toxicity as assessed by release of haemoglobin and potassium demonstrated no toxic effect as compared with conventional solution formulation. Antifungal activity in vitro was comparable to solution formulation when tested by broth dilution method.

Links

Publisher Full Text

Authors+Show Affiliations

Angra PK
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA.
Oettinger C
No affiliation info available
Balakrishna Pai S
No affiliation info available
D'Souza MJ
No affiliation info available

MeSH

Amphotericin BAntifungal AgentsCalorimetry, Differential ScanningErythrocytesHumansMicrospheresParticle SizePolyethylene GlycolsSpectroscopy, Fourier Transform Infrared

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19839793

Citation

Angra, Pawan K., et al. "Amphotericin B Microspheres: a Therapeutic Approach to Minimize Toxicity While Maintaining Antifungal Efficacy." Journal of Microencapsulation, vol. 26, no. 7, 2009, pp. 580-7.
Angra PK, Oettinger C, Balakrishna Pai S, et al. Amphotericin B microspheres: a therapeutic approach to minimize toxicity while maintaining antifungal efficacy. J Microencapsul. 2009;26(7):580-7.
Angra, P. K., Oettinger, C., Balakrishna Pai, S., & D'Souza, M. J. (2009). Amphotericin B microspheres: a therapeutic approach to minimize toxicity while maintaining antifungal efficacy. Journal of Microencapsulation, 26(7), 580-7. https://doi.org/10.3109/02652040902797516
Angra PK, et al. Amphotericin B Microspheres: a Therapeutic Approach to Minimize Toxicity While Maintaining Antifungal Efficacy. J Microencapsul. 2009;26(7):580-7. PubMed PMID: 19839793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amphotericin B microspheres: a therapeutic approach to minimize toxicity while maintaining antifungal efficacy. AU - Angra,Pawan K, AU - Oettinger,Carl, AU - Balakrishna Pai,S, AU - D'Souza,Martin J, PY - 2009/10/21/entrez PY - 2009/10/21/pubmed PY - 2010/2/18/medline SP - 580 EP - 7 JF - Journal of microencapsulation JO - J Microencapsul VL - 26 IS - 7 N2 - Amphotericin B microsphere formulations with and without addition of polyethylene glycol 2000 in cross-linked bovine serum albumin were prepared. Amphotericin B microspheres were characterized for particle size (<5 microm), zeta potential (approximately 30 mV) and drug interaction by DSC and FTIR and were found to be stable formulations. Drug release profiles for these microspheres revealed that the release was primarily by diffusion. In vitro toxicity as assessed by release of haemoglobin and potassium demonstrated no toxic effect as compared with conventional solution formulation. Antifungal activity in vitro was comparable to solution formulation when tested by broth dilution method. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/19839793/Amphotericin_B_microspheres:_a_therapeutic_approach_to_minimize_toxicity_while_maintaining_antifungal_efficacy_ L2 - https://www.tandfonline.com/doi/full/10.3109/02652040902797516 DB - PRIME DP - Unbound Medicine ER -