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Pharmacokinetic and biodistribution studies of amphotericin B microspheres.
J Microencapsul. 2009 Nov; 26(7):627-34.JM

Abstract

The pharmacokinetics of Amphotericin B (AmB) from polyethylene glycol 2000 (PEG 2000) entrapped cross-linked bovine serum albumin (BSA) microsphere formulations were investigated and compared with solution formulation. The microsphere preparations were characterized for particle size using electron microscopy, zeta potential and encapsulation efficiency. The microsphere formulations demonstrated a sustained release of AmB for a longer period of time, with no rise in plasma creatinine and potassium levels. The enhanced AmB accumulation in lungs was observed which could be of importance since lungs are the primary target in most fungal infections. The stealth property of submicron cross-linked BSA microspheres in formulations containing PEG 2000 (formulation F-2N) and without PEG 2000 (formulation F-1N) was also evaluated. There was no evidence that microspheres embedded with PEG remained longer in circulation; however, it was noticed that the internalization of formulation F-2N microspheres was delayed when compared with microspheres from formulation F-1N.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19839798

Citation

Angra, Pawan K., et al. "Pharmacokinetic and Biodistribution Studies of Amphotericin B Microspheres." Journal of Microencapsulation, vol. 26, no. 7, 2009, pp. 627-34.
Angra PK, Siddig A, Nettey H, et al. Pharmacokinetic and biodistribution studies of amphotericin B microspheres. J Microencapsul. 2009;26(7):627-34.
Angra, P. K., Siddig, A., Nettey, H., Desai, N., Oettinger, C., & D'Souza, M. J. (2009). Pharmacokinetic and biodistribution studies of amphotericin B microspheres. Journal of Microencapsulation, 26(7), 627-34. https://doi.org/10.3109/02652040802587173
Angra PK, et al. Pharmacokinetic and Biodistribution Studies of Amphotericin B Microspheres. J Microencapsul. 2009;26(7):627-34. PubMed PMID: 19839798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetic and biodistribution studies of amphotericin B microspheres. AU - Angra,Pawan K, AU - Siddig,Aladin, AU - Nettey,Henry, AU - Desai,Nishil, AU - Oettinger,Carl, AU - D'Souza,Martin J, PY - 2009/10/21/entrez PY - 2009/10/21/pubmed PY - 2010/2/18/medline SP - 627 EP - 34 JF - Journal of microencapsulation JO - J Microencapsul VL - 26 IS - 7 N2 - The pharmacokinetics of Amphotericin B (AmB) from polyethylene glycol 2000 (PEG 2000) entrapped cross-linked bovine serum albumin (BSA) microsphere formulations were investigated and compared with solution formulation. The microsphere preparations were characterized for particle size using electron microscopy, zeta potential and encapsulation efficiency. The microsphere formulations demonstrated a sustained release of AmB for a longer period of time, with no rise in plasma creatinine and potassium levels. The enhanced AmB accumulation in lungs was observed which could be of importance since lungs are the primary target in most fungal infections. The stealth property of submicron cross-linked BSA microspheres in formulations containing PEG 2000 (formulation F-2N) and without PEG 2000 (formulation F-1N) was also evaluated. There was no evidence that microspheres embedded with PEG remained longer in circulation; however, it was noticed that the internalization of formulation F-2N microspheres was delayed when compared with microspheres from formulation F-1N. SN - 1464-5246 UR - https://www.unboundmedicine.com/medline/citation/19839798/Pharmacokinetic_and_biodistribution_studies_of_amphotericin_B_microspheres_ L2 - https://www.tandfonline.com/doi/full/10.3109/02652040802587173 DB - PRIME DP - Unbound Medicine ER -