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Reduction of kidney damage by supplementation of vitamins C and E in rats with deoxycorticosterone-salt-induced hypertension.
Iran J Kidney Dis. 2009 Oct; 3(4):197-202.IJ

Abstract

INTRODUCTION

We assessed whether co-supplementation of vitamins C and E has additive beneficial effects on reducing the kidney damage and attenuation of the arterial pressure elevation compared to administration of either vitamin C or vitamin E alone in deoxycorticosterone acetate-salt-induced hypertension.

MATERIALS AND METHODS

Forty rats were divided into 4 study groups and 1 sham-operated group. Unilateral nephrectomy was carried out in the study groups and hypertension was induced by deoxycorticosterone injection and 1% sodium chloride and 0.2% potassium chloride added to the drinking water. Vitamins C and E (200 mg/kg/day) or combination of them were administered with DOCA-salt for 4 weeks in 3 study groups. The effects of DOCA and salt and treatment with vitamins were compared in terms of blood pressure, urinary protein excretion, antioxidant activity of the kidneys, and renal histological changes.

RESULTS

Four weeks of supplementations of vitamins C, vitamin E, and both in the DOCA-salt-treated rats had comparable significant effects in decreasing systolic blood pressure. Urinary protein excretion and histological damage did not significantly change with the combination therapy of vitamins C and E compared to the vitamin C or E alone. The renal levels of glutathione and ferric reducing/antioxidant power in combination therapy group were similar to the two other treatment groups and were significantly higher than non-treated group.

CONCLUSIONS

Co-administration of vitamin C and E does not have an additive beneficial effect on reducing the kidney damage and hypertension compared to either vitamin C or E alone in DOCA-salt-induced hypertension.

Authors+Show Affiliations

Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19841522

Citation

Seifi, Behjat, et al. "Reduction of Kidney Damage By Supplementation of Vitamins C and E in Rats With Deoxycorticosterone-salt-induced Hypertension." Iranian Journal of Kidney Diseases, vol. 3, no. 4, 2009, pp. 197-202.
Seifi B, Kadkhodaee M, Karimian SM, et al. Reduction of kidney damage by supplementation of vitamins C and E in rats with deoxycorticosterone-salt-induced hypertension. Iran J Kidney Dis. 2009;3(4):197-202.
Seifi, B., Kadkhodaee, M., Karimian, S. M., Zahmatkesh, M., Shams, S., & Bakhshi, E. (2009). Reduction of kidney damage by supplementation of vitamins C and E in rats with deoxycorticosterone-salt-induced hypertension. Iranian Journal of Kidney Diseases, 3(4), 197-202.
Seifi B, et al. Reduction of Kidney Damage By Supplementation of Vitamins C and E in Rats With Deoxycorticosterone-salt-induced Hypertension. Iran J Kidney Dis. 2009;3(4):197-202. PubMed PMID: 19841522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of kidney damage by supplementation of vitamins C and E in rats with deoxycorticosterone-salt-induced hypertension. AU - Seifi,Behjat, AU - Kadkhodaee,Mehri, AU - Karimian,Seyed Morteza, AU - Zahmatkesh,Maryam, AU - Shams,Sedighe, AU - Bakhshi,Enayatolla, PY - 2009/04/12/received PY - 2009/08/09/accepted PY - 2009/10/21/entrez PY - 2009/10/21/pubmed PY - 2010/5/19/medline SP - 197 EP - 202 JF - Iranian journal of kidney diseases JO - Iran J Kidney Dis VL - 3 IS - 4 N2 - INTRODUCTION: We assessed whether co-supplementation of vitamins C and E has additive beneficial effects on reducing the kidney damage and attenuation of the arterial pressure elevation compared to administration of either vitamin C or vitamin E alone in deoxycorticosterone acetate-salt-induced hypertension. MATERIALS AND METHODS: Forty rats were divided into 4 study groups and 1 sham-operated group. Unilateral nephrectomy was carried out in the study groups and hypertension was induced by deoxycorticosterone injection and 1% sodium chloride and 0.2% potassium chloride added to the drinking water. Vitamins C and E (200 mg/kg/day) or combination of them were administered with DOCA-salt for 4 weeks in 3 study groups. The effects of DOCA and salt and treatment with vitamins were compared in terms of blood pressure, urinary protein excretion, antioxidant activity of the kidneys, and renal histological changes. RESULTS: Four weeks of supplementations of vitamins C, vitamin E, and both in the DOCA-salt-treated rats had comparable significant effects in decreasing systolic blood pressure. Urinary protein excretion and histological damage did not significantly change with the combination therapy of vitamins C and E compared to the vitamin C or E alone. The renal levels of glutathione and ferric reducing/antioxidant power in combination therapy group were similar to the two other treatment groups and were significantly higher than non-treated group. CONCLUSIONS: Co-administration of vitamin C and E does not have an additive beneficial effect on reducing the kidney damage and hypertension compared to either vitamin C or E alone in DOCA-salt-induced hypertension. SN - 1735-8582 UR - https://www.unboundmedicine.com/medline/citation/19841522/Reduction_of_kidney_damage_by_supplementation_of_vitamins_C_and_E_in_rats_with_deoxycorticosterone_salt_induced_hypertension_ L2 - http://www.ijkd.org/index.php/ijkd/article/view/65/125 DB - PRIME DP - Unbound Medicine ER -