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Estimation of glomerular filtration rate with creatinine-based versus cystatin C-based equations in kidney transplant recipients.
Iran J Kidney Dis. 2009 Oct; 3(4):234-8.IJ

Abstract

INTRODUCTION

Serum cystatin C is more sensitive for glomerular filtration rate (GFR) measurement, but it is not available for clinical use in all laboratories. Regarding the importance of accurate estimation of GFR in kidney transplant recipients, we compared cystatin C-based equations with creatinine-based formulas to estimate GFR as precisely and simply as possible in kidney transplant recipients.

MATERIALS AND METHODS

Seventy living donor kidney transplant recipients with stable kidney function were enrolled in our study. The patients' GFRs were estimated by 3 creatinine-based equations (the modification of diet in renal disease [MDRD], abbreviated MDRD, and Cockcroft-Gault) and 5 cystatin C-based equations (Filler, Le Bricon, Rule, Hoek, and Larsson), and the results were analyzed.

RESULTS

The mean age of the recipients was 38.7 +/- 13.4 years. The mean GFRs were 67.1 +/- 25.9 mL/min/1.73 m2, by the Cockcroft-Gault; 61.0 +/- 17.7 mL/min/1.73 m2, by the abbreviated MDRD; and 60.0 +/-18.6 mL/min/1.73 m2, by the MDRD formulas. Cystatin C-based GFR estimations were 43.6 +/- 16.2 mL/min/1.73 m2, 44.0 +/- 13.2 mL/min/1.73 m2, 33.8 +/- 14.1 mL/min/1.73 m2, 35.6 +/- 13.7 mL/min/1.73 m2, and 36.9 +/- 13.6 mL/min/1.73 m2 by the Filler, Le Bricon, Larsson, Rule, and Hoek equations, respectively. The estimates by creatinine-based and cystatin C-based equations were significantly different and the MDRD estimate was the closest to the cystatin C-based GFRs.

CONCLUSIONS

Our findings revealed the MDRD equation could be provide a closer estimate of GFR to the cystatin C-based equations than other creatinine-based GFR calculations in kidney transplant recipients.

Authors+Show Affiliations

Department of Nephrology and Transplant, Hasheminejad Kidney Hospital, Iran University of Medical Sciences, Tehran, Iran. ssavaj@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19841528

Citation

Savaj, Shokoufeh, et al. "Estimation of Glomerular Filtration Rate With Creatinine-based Versus Cystatin C-based Equations in Kidney Transplant Recipients." Iranian Journal of Kidney Diseases, vol. 3, no. 4, 2009, pp. 234-8.
Savaj S, Shoushtarizadeh T, Abbasi MA, et al. Estimation of glomerular filtration rate with creatinine-based versus cystatin C-based equations in kidney transplant recipients. Iran J Kidney Dis. 2009;3(4):234-8.
Savaj, S., Shoushtarizadeh, T., Abbasi, M. A., Razavimanesh, S. H., & Ghods, A. J. (2009). Estimation of glomerular filtration rate with creatinine-based versus cystatin C-based equations in kidney transplant recipients. Iranian Journal of Kidney Diseases, 3(4), 234-8.
Savaj S, et al. Estimation of Glomerular Filtration Rate With Creatinine-based Versus Cystatin C-based Equations in Kidney Transplant Recipients. Iran J Kidney Dis. 2009;3(4):234-8. PubMed PMID: 19841528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimation of glomerular filtration rate with creatinine-based versus cystatin C-based equations in kidney transplant recipients. AU - Savaj,Shokoufeh, AU - Shoushtarizadeh,Tina, AU - Abbasi,Mohammad Amin, AU - Razavimanesh,Sayed Heidar, AU - Ghods,Ahad J, PY - 2009/04/30/received PY - 2009/08/24/accepted PY - 2009/10/21/entrez PY - 2009/10/21/pubmed PY - 2010/5/19/medline SP - 234 EP - 8 JF - Iranian journal of kidney diseases JO - Iran J Kidney Dis VL - 3 IS - 4 N2 - INTRODUCTION: Serum cystatin C is more sensitive for glomerular filtration rate (GFR) measurement, but it is not available for clinical use in all laboratories. Regarding the importance of accurate estimation of GFR in kidney transplant recipients, we compared cystatin C-based equations with creatinine-based formulas to estimate GFR as precisely and simply as possible in kidney transplant recipients. MATERIALS AND METHODS: Seventy living donor kidney transplant recipients with stable kidney function were enrolled in our study. The patients' GFRs were estimated by 3 creatinine-based equations (the modification of diet in renal disease [MDRD], abbreviated MDRD, and Cockcroft-Gault) and 5 cystatin C-based equations (Filler, Le Bricon, Rule, Hoek, and Larsson), and the results were analyzed. RESULTS: The mean age of the recipients was 38.7 +/- 13.4 years. The mean GFRs were 67.1 +/- 25.9 mL/min/1.73 m2, by the Cockcroft-Gault; 61.0 +/- 17.7 mL/min/1.73 m2, by the abbreviated MDRD; and 60.0 +/-18.6 mL/min/1.73 m2, by the MDRD formulas. Cystatin C-based GFR estimations were 43.6 +/- 16.2 mL/min/1.73 m2, 44.0 +/- 13.2 mL/min/1.73 m2, 33.8 +/- 14.1 mL/min/1.73 m2, 35.6 +/- 13.7 mL/min/1.73 m2, and 36.9 +/- 13.6 mL/min/1.73 m2 by the Filler, Le Bricon, Larsson, Rule, and Hoek equations, respectively. The estimates by creatinine-based and cystatin C-based equations were significantly different and the MDRD estimate was the closest to the cystatin C-based GFRs. CONCLUSIONS: Our findings revealed the MDRD equation could be provide a closer estimate of GFR to the cystatin C-based equations than other creatinine-based GFR calculations in kidney transplant recipients. SN - 1735-8582 UR - https://www.unboundmedicine.com/medline/citation/19841528/Estimation_of_glomerular_filtration_rate_with_creatinine_based_versus_cystatin_C_based_equations_in_kidney_transplant_recipients_ L2 - http://www.ijkd.org/index.php/ijkd/article/view/123/130 DB - PRIME DP - Unbound Medicine ER -