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Gold nanoparticle based surface-enhanced Raman scattering spectroscopy of cancerous and normal nasopharyngeal tissues under near-infrared laser excitation.
Appl Spectrosc. 2009 Oct; 63(10):1089-94.AS

Abstract

The capabilities of using gold nanoparticle based near-infrared surface-enhanced Raman scattering (SERS) to obtain biochemical information with high spatial resolution from human nasopharyngeal tissue were presented in this paper. The gold nanoparticles used have a mean diameter of 43 nm with a standard deviation of 6 nm. The SERS bands of nasopharyngeal tissue were assigned to known molecular vibrations of nucleic acids, amino acids, proteins, and metabolites. We also observed the blinking phenomenon at the tissue level when measuring the nasopharyngeal tissue SERS spectra, most frequently in signal intensity but also occasionally in peak positions. This phenomenon is excitation light intensity dependent. This work demonstrated great potential for using SERS imaging for distinguishing cancerous and normal nasopharyngeal tissues on frozen sections without using any dye labeling or other chemical species as functionalized binding sites.

Authors+Show Affiliations

Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19843357

Citation

Feng, Shangyuan, et al. "Gold Nanoparticle Based Surface-enhanced Raman Scattering Spectroscopy of Cancerous and Normal Nasopharyngeal Tissues Under Near-infrared Laser Excitation." Applied Spectroscopy, vol. 63, no. 10, 2009, pp. 1089-94.
Feng S, Lin J, Cheng M, et al. Gold nanoparticle based surface-enhanced Raman scattering spectroscopy of cancerous and normal nasopharyngeal tissues under near-infrared laser excitation. Appl Spectrosc. 2009;63(10):1089-94.
Feng, S., Lin, J., Cheng, M., Li, Y. Z., Chen, G., Huang, Z., Yu, Y., Chen, R., & Zeng, H. (2009). Gold nanoparticle based surface-enhanced Raman scattering spectroscopy of cancerous and normal nasopharyngeal tissues under near-infrared laser excitation. Applied Spectroscopy, 63(10), 1089-94. https://doi.org/10.1366/000370209789553291
Feng S, et al. Gold Nanoparticle Based Surface-enhanced Raman Scattering Spectroscopy of Cancerous and Normal Nasopharyngeal Tissues Under Near-infrared Laser Excitation. Appl Spectrosc. 2009;63(10):1089-94. PubMed PMID: 19843357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gold nanoparticle based surface-enhanced Raman scattering spectroscopy of cancerous and normal nasopharyngeal tissues under near-infrared laser excitation. AU - Feng,Shangyuan, AU - Lin,Juqiang, AU - Cheng,Min, AU - Li,Yong-Zeng, AU - Chen,Guannan, AU - Huang,Zufang, AU - Yu,Yun, AU - Chen,Rong, AU - Zeng,Haishan, PY - 2009/10/22/entrez PY - 2009/10/22/pubmed PY - 2010/1/22/medline SP - 1089 EP - 94 JF - Applied spectroscopy JO - Appl Spectrosc VL - 63 IS - 10 N2 - The capabilities of using gold nanoparticle based near-infrared surface-enhanced Raman scattering (SERS) to obtain biochemical information with high spatial resolution from human nasopharyngeal tissue were presented in this paper. The gold nanoparticles used have a mean diameter of 43 nm with a standard deviation of 6 nm. The SERS bands of nasopharyngeal tissue were assigned to known molecular vibrations of nucleic acids, amino acids, proteins, and metabolites. We also observed the blinking phenomenon at the tissue level when measuring the nasopharyngeal tissue SERS spectra, most frequently in signal intensity but also occasionally in peak positions. This phenomenon is excitation light intensity dependent. This work demonstrated great potential for using SERS imaging for distinguishing cancerous and normal nasopharyngeal tissues on frozen sections without using any dye labeling or other chemical species as functionalized binding sites. SN - 1943-3530 UR - https://www.unboundmedicine.com/medline/citation/19843357/Gold_nanoparticle_based_surface_enhanced_Raman_scattering_spectroscopy_of_cancerous_and_normal_nasopharyngeal_tissues_under_near_infrared_laser_excitation_ L2 - https://journals.sagepub.com/doi/10.1366/000370209789553291?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -