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Antioxidant supplementation lowers circulating IGF-1 but not F(2)-isoprostanes immediately following anterior cruciate ligament surgery.
Redox Rep. 2009; 14(5):221-6.RR

Abstract

Interleukin (IL)-10 is an anti-inflammatory cytokine that suppresses pro-inflammatory cytokines. We previously demonstrated that supplementation with vitamins E and C ameliorated the increase in IL-10 immediately following anterior cruciate ligament (ACL) surgery in the absence of other cytokine perturbations. Since both oxidative stress and insulin-like growth factor-1 (IGF-1) can modulate IL-10 concentrations, the mechanisms for these changes warranted further investigation. Our objective was to evaluate the mechanism for the IL-10 decrease following ACL surgery. This study consisted of randomized, double-blind, placebo-controlled experimental design. Subjects were randomly assigned to daily supplementation with either: (i) antioxidants (AO; vitamins E [alpha-tocopherol] and C [ascorbic acid]; n = 10); or (ii) matching placebos (PL; n = 10). Supplementation started approximately 2 weeks prior to surgery (baseline) and concluded 3 months after surgery. Subjects provided six fasting blood samples at: (i) baseline; (ii) immediately pre-surgery (Pre); (iii) 90 min; (iv) 72 h; (v) 7 days; and (vi) 3 months post-surgery. alpha-Tocopherol, ascorbic acid, F(2)-isoprostane and IGF-1 concentrations were measured in each blood sample. At 90 min relative to other times, plasma F(2)-isoprostane concentrations were significantly (P < 0.05) elevated in both groups, while at 90 min IGF-1 was significantly (P < 0.05) lower in the AO compared to the PL group. The changes in IGF-1 at 90 min relative to baseline were correlated (P < 0.0001) with the changes in IL-10. The decrease in IL-10 observed in the AO group is likely dependent on the decrease IGF-1 since lipid peroxidation was unchanged between the two groups.

Authors+Show Affiliations

Sport Science Department, The Orthopedic Specialty Hospital, Murray, Utah, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19843377

Citation

Barker, Tyler, et al. "Antioxidant Supplementation Lowers Circulating IGF-1 but Not F(2)-isoprostanes Immediately Following Anterior Cruciate Ligament Surgery." Redox Report : Communications in Free Radical Research, vol. 14, no. 5, 2009, pp. 221-6.
Barker T, Leonard SW, Trawick RH, et al. Antioxidant supplementation lowers circulating IGF-1 but not F(2)-isoprostanes immediately following anterior cruciate ligament surgery. Redox Rep. 2009;14(5):221-6.
Barker, T., Leonard, S. W., Trawick, R. H., Walker, J. A., & Traber, M. G. (2009). Antioxidant supplementation lowers circulating IGF-1 but not F(2)-isoprostanes immediately following anterior cruciate ligament surgery. Redox Report : Communications in Free Radical Research, 14(5), 221-6. https://doi.org/10.1179/135100009X12525712409535
Barker T, et al. Antioxidant Supplementation Lowers Circulating IGF-1 but Not F(2)-isoprostanes Immediately Following Anterior Cruciate Ligament Surgery. Redox Rep. 2009;14(5):221-6. PubMed PMID: 19843377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant supplementation lowers circulating IGF-1 but not F(2)-isoprostanes immediately following anterior cruciate ligament surgery. AU - Barker,Tyler, AU - Leonard,Scott W, AU - Trawick,Roy H, AU - Walker,James A, AU - Traber,Maret G, PY - 2009/10/22/entrez PY - 2009/10/22/pubmed PY - 2010/1/16/medline SP - 221 EP - 6 JF - Redox report : communications in free radical research JO - Redox Rep VL - 14 IS - 5 N2 - Interleukin (IL)-10 is an anti-inflammatory cytokine that suppresses pro-inflammatory cytokines. We previously demonstrated that supplementation with vitamins E and C ameliorated the increase in IL-10 immediately following anterior cruciate ligament (ACL) surgery in the absence of other cytokine perturbations. Since both oxidative stress and insulin-like growth factor-1 (IGF-1) can modulate IL-10 concentrations, the mechanisms for these changes warranted further investigation. Our objective was to evaluate the mechanism for the IL-10 decrease following ACL surgery. This study consisted of randomized, double-blind, placebo-controlled experimental design. Subjects were randomly assigned to daily supplementation with either: (i) antioxidants (AO; vitamins E [alpha-tocopherol] and C [ascorbic acid]; n = 10); or (ii) matching placebos (PL; n = 10). Supplementation started approximately 2 weeks prior to surgery (baseline) and concluded 3 months after surgery. Subjects provided six fasting blood samples at: (i) baseline; (ii) immediately pre-surgery (Pre); (iii) 90 min; (iv) 72 h; (v) 7 days; and (vi) 3 months post-surgery. alpha-Tocopherol, ascorbic acid, F(2)-isoprostane and IGF-1 concentrations were measured in each blood sample. At 90 min relative to other times, plasma F(2)-isoprostane concentrations were significantly (P < 0.05) elevated in both groups, while at 90 min IGF-1 was significantly (P < 0.05) lower in the AO compared to the PL group. The changes in IGF-1 at 90 min relative to baseline were correlated (P < 0.0001) with the changes in IL-10. The decrease in IL-10 observed in the AO group is likely dependent on the decrease IGF-1 since lipid peroxidation was unchanged between the two groups. SN - 1743-2928 UR - https://www.unboundmedicine.com/medline/citation/19843377/Antioxidant_supplementation_lowers_circulating_IGF_1_but_not_F_2__isoprostanes_immediately_following_anterior_cruciate_ligament_surgery_ L2 - https://www.tandfonline.com/doi/full/10.1179/135100009X12525712409535 DB - PRIME DP - Unbound Medicine ER -