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Associations between silicone skin cast score, cumulative sun exposure, and other factors in the ausimmune study: a multicenter Australian study.
Cancer Epidemiol Biomarkers Prev 2009; 18(11):2887-94CE

Abstract

Past sun exposure is linked to a wide range of disease outcomes but is difficult to measure accurately. Silicone skin casts measure skin damage, but some studies show that age rather than sun exposure is the most important determinant of cast score. We examined skin damage scores from silicone casts of the back of the hand in a large adult sample (n = 534) with a broad range of past cumulative UV radiation (UVR) doses. Participants were ages 18 to 61 years and resided in one of four locations down the eastern Australian seaboard, spanning 27-43 degrees S. Data were collected by questionnaire and during a nurse-led interview and examination. Silicone casts were graded from 1 to 6, where higher score represents greater damage. Higher skin damage score was associated with lighter skin pigmentation [adjusted odds ratio (AOR), 4.51; 95% confidence interval (95% CI), 2.33-8.75], fairer natural hair color, particularly red hair (AOR, 11.31; 95% CI, 4.08-31.36), and blue/gray eyes (AOR, 1.72; 95% CI, 1.14-2.59). Higher cumulative UVR dose, particularly before age 18 years, was associated with higher skin damage score (AOR, 2.06; 95% CI, 1.15-2.67 per 1,000 KJ/m(2)), as was number of sunburns, even after adjustment for cumulative UVR dose (AOR, 2.86; 95% CI, 1.50-5.43 for >10 sunburns ever compared with no sunburns ever). Silicone casts of the dorsum of the hand provide a measure of cumulative UVR dose and number of sunburns over the lifetime, which persists after adjustment for chronological age. They can be used as an objective measure of cumulative past sun exposure in epidemiologic studies, but other determinants of skin damage, such as skin pigmentation, should be concurrently evaluated.

Authors+Show Affiliations

National Centre for Epidemiology and Population Health, The Australian National University, Canberra 0200, Australian Capital Territory, Australia. robyn.lucas@anu.edu.au.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

19843682

Citation

Lucas, Robyn M., et al. "Associations Between Silicone Skin Cast Score, Cumulative Sun Exposure, and Other Factors in the Ausimmune Study: a Multicenter Australian Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 11, 2009, pp. 2887-94.
Lucas RM, Ponsonby AL, Dear K, et al. Associations between silicone skin cast score, cumulative sun exposure, and other factors in the ausimmune study: a multicenter Australian study. Cancer Epidemiol Biomarkers Prev. 2009;18(11):2887-94.
Lucas, R. M., Ponsonby, A. L., Dear, K., Taylor, B. V., Dwyer, T., McMichael, A. J., ... Kilpatrick, T. (2009). Associations between silicone skin cast score, cumulative sun exposure, and other factors in the ausimmune study: a multicenter Australian study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(11), pp. 2887-94. doi:10.1158/1055-9965.EPI-09-0191.
Lucas RM, et al. Associations Between Silicone Skin Cast Score, Cumulative Sun Exposure, and Other Factors in the Ausimmune Study: a Multicenter Australian Study. Cancer Epidemiol Biomarkers Prev. 2009;18(11):2887-94. PubMed PMID: 19843682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between silicone skin cast score, cumulative sun exposure, and other factors in the ausimmune study: a multicenter Australian study. AU - Lucas,Robyn M, AU - Ponsonby,Anne-Louise, AU - Dear,Keith, AU - Taylor,Bruce V, AU - Dwyer,Terence, AU - McMichael,Anthony J, AU - Valery,Patricia, AU - van der Mei,Ingrid, AU - Williams,David, AU - Pender,Michael P, AU - Chapman,Caron, AU - Coulthard,Alan, AU - Kilpatrick,Trevor, Y1 - 2009/10/20/ PY - 2009/10/22/entrez PY - 2009/10/22/pubmed PY - 2010/1/28/medline SP - 2887 EP - 94 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 18 IS - 11 N2 - Past sun exposure is linked to a wide range of disease outcomes but is difficult to measure accurately. Silicone skin casts measure skin damage, but some studies show that age rather than sun exposure is the most important determinant of cast score. We examined skin damage scores from silicone casts of the back of the hand in a large adult sample (n = 534) with a broad range of past cumulative UV radiation (UVR) doses. Participants were ages 18 to 61 years and resided in one of four locations down the eastern Australian seaboard, spanning 27-43 degrees S. Data were collected by questionnaire and during a nurse-led interview and examination. Silicone casts were graded from 1 to 6, where higher score represents greater damage. Higher skin damage score was associated with lighter skin pigmentation [adjusted odds ratio (AOR), 4.51; 95% confidence interval (95% CI), 2.33-8.75], fairer natural hair color, particularly red hair (AOR, 11.31; 95% CI, 4.08-31.36), and blue/gray eyes (AOR, 1.72; 95% CI, 1.14-2.59). Higher cumulative UVR dose, particularly before age 18 years, was associated with higher skin damage score (AOR, 2.06; 95% CI, 1.15-2.67 per 1,000 KJ/m(2)), as was number of sunburns, even after adjustment for cumulative UVR dose (AOR, 2.86; 95% CI, 1.50-5.43 for >10 sunburns ever compared with no sunburns ever). Silicone casts of the dorsum of the hand provide a measure of cumulative UVR dose and number of sunburns over the lifetime, which persists after adjustment for chronological age. They can be used as an objective measure of cumulative past sun exposure in epidemiologic studies, but other determinants of skin damage, such as skin pigmentation, should be concurrently evaluated. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/19843682/Associations_between_silicone_skin_cast_score_cumulative_sun_exposure_and_other_factors_in_the_ausimmune_study:_a_multicenter_Australian_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19843682 DB - PRIME DP - Unbound Medicine ER -