TY - JOUR T1 - [2-(14)C-Methylerythritol 2,4-cyclodiphosphate incorporation into bacterial and plant isoprenoids]. AU - Mazikin,K V, AU - Ershov,Iu V, AU - goncharenko,A V, AU - Ostrovskiĭ,D N, PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2009/11/10/medline SP - 561 EP - 4 JF - Prikladnaia biokhimiia i mikrobiologiia JO - Prikl Biokhim Mikrobiol VL - 45 IS - 5 N2 - To work out a test system for studying the inhibition of isoprenoid biosynthesis through non-mevalonate pathway, the conversion of 2-(14)C-methylerythritol 2,4-cyclodiphosphate (14C-MEC) into isoprenoids of three bacteria species and into plastids of 11 higher plant species was studied. The highest efficiency (up to 63%) of the process was observed with chromoplasts from narcissus (Narcissus pseudonarcissus L.) and celandine (Chelidonium majus L.). Twenty five percent of added 14C-MEC was recovered in an isoprenoid fraction of red pepper (Capsicum annuum L.) chromoplasts. Thus, these three models can be used to test antibiotic inhibitors of isoprenoid biosynthesis. SN - 0555-1099 UR - https://www.unboundmedicine.com/medline/citation/19845288/[2__14_C_Methylerythritol_24_cyclodiphosphate_incorporation_into_bacterial_and_plant_isoprenoids]_ DB - PRIME DP - Unbound Medicine ER -