Tags

Type your tag names separated by a space and hit enter

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial.
Br J Dermatol. 2010 Feb 01; 162(2):435-41.BJ

Abstract

BACKGROUND

Topical niacinamide and N-acetyl glucosamine (NAG) each individually inhibit epidermal pigmentation in cell culture. In small clinical studies, niacinamide-containing and NAG-containing formulations reduced the appearance of hyperpigmentation.

OBJECTIVES

To assess the effect of a combination of niacinamide and NAG in a topical moisturizing formulation on irregular facial pigmentation, including specific detection of changes in colour features associated with melanin.

METHODS

This was a 10-week, double-blind, vehicle-controlled, full-face, parallel-group clinical study conducted in women aged 40-60 years. After a 2-week washout period, subjects used a daily regimen of either a morning sun protection factor (SPF) 15 sunscreen moisturizing lotion and evening moisturizing cream each containing 4% niacinamide + 2% NAG (test formulation; n = 101) or the SPF 15 lotion and cream vehicles (vehicle control; n = 101). Product-induced changes in apparent pigmentation were assessed by capturing digital photographic images of the women after 0, 4, 6 and 8 weeks of product use and evaluating the images by algorithm-based computer image analysis for coloured spot area fraction, by expert visual grading, and by chromophore-specific image analysis based on noncontact SIAscopy for melanin spot area fraction and melanin chromophore evenness.

RESULTS

By all four measures, the niacinamide + NAG formulation regimen was significantly (P < 0.05) more effective than the vehicle control formulation regimen in reducing the detectable area of facial spots and the appearance of pigmentation.

CONCLUSIONS

A formulation containing the combination of niacinamide + NAG reduced the appearance of irregular pigmentation including hypermelaninization, providing an effect beyond that achieved with SPF 15 sunscreen.

Authors+Show Affiliations

Harvard Medical School, Boston, MA 02114, USA. harvardskinstudies@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19845667

Citation

Kimball, A B., et al. "Reduction in the Appearance of Facial Hyperpigmentation After Use of Moisturizers With a Combination of Topical Niacinamide and N-acetyl Glucosamine: Results of a Randomized, Double-blind, Vehicle-controlled Trial." The British Journal of Dermatology, vol. 162, no. 2, 2010, pp. 435-41.
Kimball AB, Kaczvinsky JR, Li J, et al. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Br J Dermatol. 2010;162(2):435-41.
Kimball, A. B., Kaczvinsky, J. R., Li, J., Robinson, L. R., Matts, P. J., Berge, C. A., Miyamoto, K., & Bissett, D. L. (2010). Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. The British Journal of Dermatology, 162(2), 435-41. https://doi.org/10.1111/j.1365-2133.2009.09477.x
Kimball AB, et al. Reduction in the Appearance of Facial Hyperpigmentation After Use of Moisturizers With a Combination of Topical Niacinamide and N-acetyl Glucosamine: Results of a Randomized, Double-blind, Vehicle-controlled Trial. Br J Dermatol. 2010 Feb 1;162(2):435-41. PubMed PMID: 19845667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. AU - Kimball,A B, AU - Kaczvinsky,J R, AU - Li,J, AU - Robinson,L R, AU - Matts,P J, AU - Berge,C A, AU - Miyamoto,K, AU - Bissett,D L, Y1 - 2009/08/28/ PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/5/27/medline SP - 435 EP - 41 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 162 IS - 2 N2 - BACKGROUND: Topical niacinamide and N-acetyl glucosamine (NAG) each individually inhibit epidermal pigmentation in cell culture. In small clinical studies, niacinamide-containing and NAG-containing formulations reduced the appearance of hyperpigmentation. OBJECTIVES: To assess the effect of a combination of niacinamide and NAG in a topical moisturizing formulation on irregular facial pigmentation, including specific detection of changes in colour features associated with melanin. METHODS: This was a 10-week, double-blind, vehicle-controlled, full-face, parallel-group clinical study conducted in women aged 40-60 years. After a 2-week washout period, subjects used a daily regimen of either a morning sun protection factor (SPF) 15 sunscreen moisturizing lotion and evening moisturizing cream each containing 4% niacinamide + 2% NAG (test formulation; n = 101) or the SPF 15 lotion and cream vehicles (vehicle control; n = 101). Product-induced changes in apparent pigmentation were assessed by capturing digital photographic images of the women after 0, 4, 6 and 8 weeks of product use and evaluating the images by algorithm-based computer image analysis for coloured spot area fraction, by expert visual grading, and by chromophore-specific image analysis based on noncontact SIAscopy for melanin spot area fraction and melanin chromophore evenness. RESULTS: By all four measures, the niacinamide + NAG formulation regimen was significantly (P < 0.05) more effective than the vehicle control formulation regimen in reducing the detectable area of facial spots and the appearance of pigmentation. CONCLUSIONS: A formulation containing the combination of niacinamide + NAG reduced the appearance of irregular pigmentation including hypermelaninization, providing an effect beyond that achieved with SPF 15 sunscreen. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/19845667/Reduction_in_the_appearance_of_facial_hyperpigmentation_after_use_of_moisturizers_with_a_combination_of_topical_niacinamide_and_N_acetyl_glucosamine:_results_of_a_randomized_double_blind_vehicle_controlled_trial_ L2 - https://doi.org/10.1111/j.1365-2133.2009.09477.x DB - PRIME DP - Unbound Medicine ER -