Tags

Type your tag names separated by a space and hit enter

Non-alcoholic fatty liver disease from pathogenesis to management: an update.
Obes Rev. 2010 Jun; 11(6):430-45.OR

Abstract

Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the Western world, is tightly associated with obesity and metabolic syndrome. NAFLD entails an increased cardiometabolic and liver-related risk, the latter regarding almost exclusively non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Pathogenetic models encompass altered hepatic lipid partitioning and adipokine action, increased oxidative stress, free fatty acid lipotoxicity. On this basis, lifestyle-, drug- or surgically induced weight loss, insulin sensitizers, antioxidants, lipid-lowering drugs have been evaluated in NAFLD/NASH. Most trials are small, of short duration, nonrandomized, without histological end points, thus limiting assessment of long-term safety and efficacy of proposed treatments. All NAFLD patients should be evaluated for their metabolic, cardiovascular and liver-related risk. Liver biopsy remains the gold standard for staging NAFLD, but non-invasive methods are under intense development. Weight loss through lifestyle intervention is the initial approach, because of established efficacy on NAFLD-associated cardiometabolic abnormalities, and to emerging benefits on necroinflammation and overall disease activity in NASH. Bariatric surgery warrants further evaluation before it can be routinely considered in morbidly obese NASH. Larger- and longer-duration randomized trials assessing safety and benefits of drugs on patient-oriented outcomes are needed before pharmacological treatment can be routinely recommended for NASH.

Authors+Show Affiliations

Gradenigo Hospital, Turin, Italy. giovanni_musso@yahoo.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19845871

Citation

Musso, G, et al. "Non-alcoholic Fatty Liver Disease From Pathogenesis to Management: an Update." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 11, no. 6, 2010, pp. 430-45.
Musso G, Gambino R, Cassader M. Non-alcoholic fatty liver disease from pathogenesis to management: an update. Obes Rev. 2010;11(6):430-45.
Musso, G., Gambino, R., & Cassader, M. (2010). Non-alcoholic fatty liver disease from pathogenesis to management: an update. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 11(6), 430-45. https://doi.org/10.1111/j.1467-789X.2009.00657.x
Musso G, Gambino R, Cassader M. Non-alcoholic Fatty Liver Disease From Pathogenesis to Management: an Update. Obes Rev. 2010;11(6):430-45. PubMed PMID: 19845871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-alcoholic fatty liver disease from pathogenesis to management: an update. AU - Musso,G, AU - Gambino,R, AU - Cassader,M, Y1 - 2009/10/21/ PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/10/5/medline SP - 430 EP - 45 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 11 IS - 6 N2 - Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the Western world, is tightly associated with obesity and metabolic syndrome. NAFLD entails an increased cardiometabolic and liver-related risk, the latter regarding almost exclusively non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Pathogenetic models encompass altered hepatic lipid partitioning and adipokine action, increased oxidative stress, free fatty acid lipotoxicity. On this basis, lifestyle-, drug- or surgically induced weight loss, insulin sensitizers, antioxidants, lipid-lowering drugs have been evaluated in NAFLD/NASH. Most trials are small, of short duration, nonrandomized, without histological end points, thus limiting assessment of long-term safety and efficacy of proposed treatments. All NAFLD patients should be evaluated for their metabolic, cardiovascular and liver-related risk. Liver biopsy remains the gold standard for staging NAFLD, but non-invasive methods are under intense development. Weight loss through lifestyle intervention is the initial approach, because of established efficacy on NAFLD-associated cardiometabolic abnormalities, and to emerging benefits on necroinflammation and overall disease activity in NASH. Bariatric surgery warrants further evaluation before it can be routinely considered in morbidly obese NASH. Larger- and longer-duration randomized trials assessing safety and benefits of drugs on patient-oriented outcomes are needed before pharmacological treatment can be routinely recommended for NASH. SN - 1467-789X UR - https://www.unboundmedicine.com/medline/citation/19845871/Non_alcoholic_fatty_liver_disease_from_pathogenesis_to_management:_an_update_ L2 - https://doi.org/10.1111/j.1467-789X.2009.00657.x DB - PRIME DP - Unbound Medicine ER -