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Hyperhomocysteinaemia, low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis.
Eur J Vasc Endovasc Surg. 2010 Apr; 39(4):508-13.EJ

Abstract

OBJECTIVES

Acute mesenteric venous thrombosis (AMVT) was first reported by Fagge and was recognised as a distinct clinical entity by Warreen in 1935. However, its pathogenesis is still unclear. Elevated plasma levels of homocysteine (Hcy) are associated with an increased risk of deep vein thrombosis. This case-control study examines the potential association among hyperhomocysteinaemia (hyper-Hcy), low serum folate and vitamin B(12) levels and the common C677T mutation of the MTHFR gene in patients with AMVT.

MATERIALS AND METHODS

Sixty-three patients with AMVT and 75 sex- and age-matched healthy controls were recruited, and their plasma Hcy, folate and vitamin B(12) levels were measured by high performance liquid chromatography (HPLC) and immunological assays. The polymorphism of MTHFR C677T was detected by PCR-RFLP.

RESULTS

The mean plasma Hcy levels were significantly higher in patients with AVMT compared with controls (23.5 standard deviation (S.D.) 8.8 vs. 12.6+/-6.6micromoll(-1), P<0.01). The fasting Hcy correlated negatively with folate (AMVT: r=-0.42, P<0.01;

CONTROL

r=-0.40, P<0.01). The frequency of homozygous (TT) genotype in MTHFR C677T mutation was significantly higher in patients with AMVT than that in control subjects (33% vs. 17%; chi square (chi(2))=6.31, P<0.05; odds ratio (OR)=2.80; 95% confidence interval (CI): 1.25-6.25). Compared with the control subjects, the mean serum vitamin B(12) levels were lower in patients, but it was not statistically significant (365+/-88pmoll(-1) vs. 408+/-108pmoll(-1), P>0.05).

CONCLUSIONS

Hyper-Hcy and low serum folate levels were associated with an increased risk of AMVT. The homozygous (TT) genotype of MTHFR gene mutation may be a crucial hereditary risk factor in the development of AMVT for a Chinese population.

Authors+Show Affiliations

Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19846322

Citation

He, J A., et al. "Hyperhomocysteinaemia, Low Folate Concentrations and Methylene Tetrahydrofolate Reductase C677T Mutation in Acute Mesenteric Venous Thrombosis." European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, vol. 39, no. 4, 2010, pp. 508-13.
He JA, Hu XH, Fan YY, et al. Hyperhomocysteinaemia, low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis. Eur J Vasc Endovasc Surg. 2010;39(4):508-13.
He, J. A., Hu, X. H., Fan, Y. Y., Yang, J., Zhang, Z. S., Liu, C. W., Yang, D. H., Zhang, J., Xin, S. J., Zhang, Q., & Duan, Z. Q. (2010). Hyperhomocysteinaemia, low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis. European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery, 39(4), 508-13. https://doi.org/10.1016/j.ejvs.2009.09.014
He JA, et al. Hyperhomocysteinaemia, Low Folate Concentrations and Methylene Tetrahydrofolate Reductase C677T Mutation in Acute Mesenteric Venous Thrombosis. Eur J Vasc Endovasc Surg. 2010;39(4):508-13. PubMed PMID: 19846322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinaemia, low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis. AU - He,J A, AU - Hu,X H, AU - Fan,Y Y, AU - Yang,J, AU - Zhang,Z S, AU - Liu,C W, AU - Yang,D H, AU - Zhang,J, AU - Xin,S J, AU - Zhang,Q, AU - Duan,Z Q, Y1 - 2009/10/20/ PY - 2009/05/02/received PY - 2009/09/20/accepted PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/4/16/medline SP - 508 EP - 13 JF - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JO - Eur J Vasc Endovasc Surg VL - 39 IS - 4 N2 - OBJECTIVES: Acute mesenteric venous thrombosis (AMVT) was first reported by Fagge and was recognised as a distinct clinical entity by Warreen in 1935. However, its pathogenesis is still unclear. Elevated plasma levels of homocysteine (Hcy) are associated with an increased risk of deep vein thrombosis. This case-control study examines the potential association among hyperhomocysteinaemia (hyper-Hcy), low serum folate and vitamin B(12) levels and the common C677T mutation of the MTHFR gene in patients with AMVT. MATERIALS AND METHODS: Sixty-three patients with AMVT and 75 sex- and age-matched healthy controls were recruited, and their plasma Hcy, folate and vitamin B(12) levels were measured by high performance liquid chromatography (HPLC) and immunological assays. The polymorphism of MTHFR C677T was detected by PCR-RFLP. RESULTS: The mean plasma Hcy levels were significantly higher in patients with AVMT compared with controls (23.5 standard deviation (S.D.) 8.8 vs. 12.6+/-6.6micromoll(-1), P<0.01). The fasting Hcy correlated negatively with folate (AMVT: r=-0.42, P<0.01; CONTROL: r=-0.40, P<0.01). The frequency of homozygous (TT) genotype in MTHFR C677T mutation was significantly higher in patients with AMVT than that in control subjects (33% vs. 17%; chi square (chi(2))=6.31, P<0.05; odds ratio (OR)=2.80; 95% confidence interval (CI): 1.25-6.25). Compared with the control subjects, the mean serum vitamin B(12) levels were lower in patients, but it was not statistically significant (365+/-88pmoll(-1) vs. 408+/-108pmoll(-1), P>0.05). CONCLUSIONS: Hyper-Hcy and low serum folate levels were associated with an increased risk of AMVT. The homozygous (TT) genotype of MTHFR gene mutation may be a crucial hereditary risk factor in the development of AMVT for a Chinese population. SN - 1532-2165 UR - https://www.unboundmedicine.com/medline/citation/19846322/Hyperhomocysteinaemia_low_folate_concentrations_and_methylene_tetrahydrofolate_reductase_C677T_mutation_in_acute_mesenteric_venous_thrombosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1078-5884(09)00495-X DB - PRIME DP - Unbound Medicine ER -