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A gain-scheduling model predictive controller for blood glucose control in type 1 diabetes.
IEEE Trans Biomed Eng. 2010 Oct; 57(10):2478-84.IT

Abstract

This paper presents a control strategy for blood glucose (BG) level regulation in type 1 diabetic patients. To design the controller, model-based predictive control scheme has been applied to a newly developed diabetic patient model. The controller is provided with a feedforward loop to improve meal compensation, a gain-scheduling scheme to account for different BG levels, and an asymmetric cost function to reduce hypoglycemic risk. A simulation environment that has been approved for testing of artificial pancreas control algorithms has been used to test the controller. The simulation results show a good controller performance in fasting conditions and meal disturbance rejection, and robustness against model-patient mismatch and errors in meal estimation.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Abu-Rmileh A
Department of Electrical, Electronics, and Control Engineering, University of Girona, 17071 Girona, Spain. amjadhisham.ahmad@udg.edu
Garcia-Gabin W
No affiliation info available

MeSH

AdultAlgorithmsBlood GlucoseBlood Glucose Self-MonitoringDiabetes Mellitus, Type 1HumansInsulin Infusion SystemsModels, Biological

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19846371

Citation

Abu-Rmileh, Amjad, and Winston Garcia-Gabin. "A Gain-scheduling Model Predictive Controller for Blood Glucose Control in Type 1 Diabetes." IEEE Transactions On Bio-medical Engineering, vol. 57, no. 10, 2010, pp. 2478-84.
Abu-Rmileh A, Garcia-Gabin W. A gain-scheduling model predictive controller for blood glucose control in type 1 diabetes. IEEE Trans Biomed Eng. 2010;57(10):2478-84.
Abu-Rmileh, A., & Garcia-Gabin, W. (2010). A gain-scheduling model predictive controller for blood glucose control in type 1 diabetes. IEEE Transactions On Bio-medical Engineering, 57(10), 2478-84. https://doi.org/10.1109/TBME.2009.2033663
Abu-Rmileh A, Garcia-Gabin W. A Gain-scheduling Model Predictive Controller for Blood Glucose Control in Type 1 Diabetes. IEEE Trans Biomed Eng. 2010;57(10):2478-84. PubMed PMID: 19846371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A gain-scheduling model predictive controller for blood glucose control in type 1 diabetes. AU - Abu-Rmileh,Amjad, AU - Garcia-Gabin,Winston, Y1 - 2009/10/20/ PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2011/1/20/medline SP - 2478 EP - 84 JF - IEEE transactions on bio-medical engineering JO - IEEE Trans Biomed Eng VL - 57 IS - 10 N2 - This paper presents a control strategy for blood glucose (BG) level regulation in type 1 diabetic patients. To design the controller, model-based predictive control scheme has been applied to a newly developed diabetic patient model. The controller is provided with a feedforward loop to improve meal compensation, a gain-scheduling scheme to account for different BG levels, and an asymmetric cost function to reduce hypoglycemic risk. A simulation environment that has been approved for testing of artificial pancreas control algorithms has been used to test the controller. The simulation results show a good controller performance in fasting conditions and meal disturbance rejection, and robustness against model-patient mismatch and errors in meal estimation. SN - 1558-2531 UR - https://www.unboundmedicine.com/medline/citation/19846371/A_gain_scheduling_model_predictive_controller_for_blood_glucose_control_in_type_1_diabetes_ DB - PRIME DP - Unbound Medicine ER -