Tags

Type your tag names separated by a space and hit enter

Choroidal filling delay in choroidal neovascularisation due to pathological myopia.
Br J Ophthalmol 2010; 94(5):611-5BJ

Abstract

AIM To assess the choroidal thickness and choroidal circulatory changes in eyes with myopic choroidal neovascularisation (mCNV).

METHODS

Retrospective, consecutive, observational case series. Forty-two consecutive eyes (17 eyes with newly diagnosed mCNV and 25 eyes without CNV) were included. Choroidal circulation was evaluated by indocyanine green angiography (ICGA), and choroidal thickness was measured by spectral-domain optical coherence tomography (SD-OCT). The factors associated with mCNV were evaluated.

RESULTS

Sixteen (94%) of 17 eyes with mCNV and six (24%) of 25 eyes without mCNV had well-defined hypofluorescence at the macular region on arterial phase ICGA, that is, a choroidal filling delay. Older age (p<0.001), the presence of a choroidal filling delay (p<0.001) and reduced choroidal thickness (p=0.003) were significantly associated with mCNV on univariate analysis. The most important of these three factors associated with mCNV, in order of importance, were the choroidal filling delay (OR=41.5, p<0.001) and choroidal thickness (per 1 microm, OR=0.97, p=0.01). Older age was significantly associated with both choroidal filling delay (per 1 year, OR=1.16, p<0.001) and choroidal thinning (regression coefficient=-1.22, p<0.001).

CONCLUSIONS

Significant choroidal changes were observed in eyes with mCNV. Ischaemia-induced growth factor expression caused by decreased choroidal perfusion may be related to the development of mCNV.

Authors+Show Affiliations

Department of Ophthalmology, Osaka University Medical School, Room E7, 2-2 Yamadaoka, Suita 565-0871, Osaka, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19846414

Citation

Wakabayashi, Taku, and Yasushi Ikuno. "Choroidal Filling Delay in Choroidal Neovascularisation Due to Pathological Myopia." The British Journal of Ophthalmology, vol. 94, no. 5, 2010, pp. 611-5.
Wakabayashi T, Ikuno Y. Choroidal filling delay in choroidal neovascularisation due to pathological myopia. Br J Ophthalmol. 2010;94(5):611-5.
Wakabayashi, T., & Ikuno, Y. (2010). Choroidal filling delay in choroidal neovascularisation due to pathological myopia. The British Journal of Ophthalmology, 94(5), pp. 611-5. doi:10.1136/bjo.2009.163535.
Wakabayashi T, Ikuno Y. Choroidal Filling Delay in Choroidal Neovascularisation Due to Pathological Myopia. Br J Ophthalmol. 2010;94(5):611-5. PubMed PMID: 19846414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Choroidal filling delay in choroidal neovascularisation due to pathological myopia. AU - Wakabayashi,Taku, AU - Ikuno,Yasushi, Y1 - 2009/10/21/ PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/7/14/medline SP - 611 EP - 5 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 94 IS - 5 N2 - AIM To assess the choroidal thickness and choroidal circulatory changes in eyes with myopic choroidal neovascularisation (mCNV). METHODS Retrospective, consecutive, observational case series. Forty-two consecutive eyes (17 eyes with newly diagnosed mCNV and 25 eyes without CNV) were included. Choroidal circulation was evaluated by indocyanine green angiography (ICGA), and choroidal thickness was measured by spectral-domain optical coherence tomography (SD-OCT). The factors associated with mCNV were evaluated. RESULTS Sixteen (94%) of 17 eyes with mCNV and six (24%) of 25 eyes without mCNV had well-defined hypofluorescence at the macular region on arterial phase ICGA, that is, a choroidal filling delay. Older age (p<0.001), the presence of a choroidal filling delay (p<0.001) and reduced choroidal thickness (p=0.003) were significantly associated with mCNV on univariate analysis. The most important of these three factors associated with mCNV, in order of importance, were the choroidal filling delay (OR=41.5, p<0.001) and choroidal thickness (per 1 microm, OR=0.97, p=0.01). Older age was significantly associated with both choroidal filling delay (per 1 year, OR=1.16, p<0.001) and choroidal thinning (regression coefficient=-1.22, p<0.001). CONCLUSIONS Significant choroidal changes were observed in eyes with mCNV. Ischaemia-induced growth factor expression caused by decreased choroidal perfusion may be related to the development of mCNV. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/19846414/Choroidal_filling_delay_in_choroidal_neovascularisation_due_to_pathological_myopia_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=19846414 DB - PRIME DP - Unbound Medicine ER -