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Effect of accelerated weightbearing after matrix-associated autologous chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after 2 years: a prospective, randomized controlled pilot study.
Am J Sports Med 2009; 37 Suppl 1:88S-96SAJ

Abstract

BACKGROUND

There is no consensus about the optimal time for weightbearing activities after matrix-associated autologous chondrocyte implantation (MACI) of the femoral condyle.

HYPOTHESIS

A comprehensive protocol after MACI on the femoral condyle with accelerated weightbearing leads to a better functional and radiographic outcome compared with the same comprehensive protocol with delayed weightbearing.

STUDY DESIGN

Randomized controlled trial; Level of evidence, 1.

METHODS

Thirty-one patients (22 male, 9 female) after MACI on the femoral condyle were randomly assigned to the accelerated weightbearing group (group A) or the delayed weightbearing group (group B). Aside from increase and time of full weightbearing, both groups adhered to the same rehabilitation protocol and exercises. Patients were assessed preoperatively and at 4, 12, 24, 52, and 104 weeks after surgery. Clinical evaluation was performed by determining the subjective form of the International Knee Documentation Committee (IKDC), the Tegner activity scale, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Radiological outcome was evaluated by the MOCART score and the size and amount of bone marrow edema and effusion.

RESULTS

In both groups, there were no differences with regard to the clinical outcome. For the radiological outcome, group A showed a higher prevalence of bone marrow edema after 6 months without correlation to the clinical outcome (P = .06-.1). However, after 104 weeks, there were no differences in the radiological outcome between group A and group B.

CONCLUSION

A rehabilitation protocol with accelerated weightbearing leads to good clinical and functional outcome after 2 years without jeopardizing the healing graft.

Authors+Show Affiliations

Center for Joints and Cartilage, Department of Traumatology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria. office@wondrasch.atNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19846693

Citation

Wondrasch, Barbara, et al. "Effect of Accelerated Weightbearing After Matrix-associated Autologous Chondrocyte Implantation On the Femoral Condyle On Radiographic and Clinical Outcome After 2 Years: a Prospective, Randomized Controlled Pilot Study." The American Journal of Sports Medicine, vol. 37 Suppl 1, 2009, 88S-96S.
Wondrasch B, Zak L, Welsch GH, et al. Effect of accelerated weightbearing after matrix-associated autologous chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after 2 years: a prospective, randomized controlled pilot study. Am J Sports Med. 2009;37 Suppl 1:88S-96S.
Wondrasch, B., Zak, L., Welsch, G. H., & Marlovits, S. (2009). Effect of accelerated weightbearing after matrix-associated autologous chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after 2 years: a prospective, randomized controlled pilot study. The American Journal of Sports Medicine, 37 Suppl 1, 88S-96S. doi:10.1177/0363546509351272.
Wondrasch B, et al. Effect of Accelerated Weightbearing After Matrix-associated Autologous Chondrocyte Implantation On the Femoral Condyle On Radiographic and Clinical Outcome After 2 Years: a Prospective, Randomized Controlled Pilot Study. Am J Sports Med. 2009;37 Suppl 1:88S-96S. PubMed PMID: 19846693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of accelerated weightbearing after matrix-associated autologous chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after 2 years: a prospective, randomized controlled pilot study. AU - Wondrasch,Barbara, AU - Zak,Lukas, AU - Welsch,Götz H, AU - Marlovits,Stefan, Y1 - 2009/10/21/ PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/3/24/medline SP - 88S EP - 96S JF - The American journal of sports medicine JO - Am J Sports Med VL - 37 Suppl 1 N2 - BACKGROUND: There is no consensus about the optimal time for weightbearing activities after matrix-associated autologous chondrocyte implantation (MACI) of the femoral condyle. HYPOTHESIS: A comprehensive protocol after MACI on the femoral condyle with accelerated weightbearing leads to a better functional and radiographic outcome compared with the same comprehensive protocol with delayed weightbearing. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: Thirty-one patients (22 male, 9 female) after MACI on the femoral condyle were randomly assigned to the accelerated weightbearing group (group A) or the delayed weightbearing group (group B). Aside from increase and time of full weightbearing, both groups adhered to the same rehabilitation protocol and exercises. Patients were assessed preoperatively and at 4, 12, 24, 52, and 104 weeks after surgery. Clinical evaluation was performed by determining the subjective form of the International Knee Documentation Committee (IKDC), the Tegner activity scale, and the Knee Injury and Osteoarthritis Outcome Score (KOOS). Radiological outcome was evaluated by the MOCART score and the size and amount of bone marrow edema and effusion. RESULTS: In both groups, there were no differences with regard to the clinical outcome. For the radiological outcome, group A showed a higher prevalence of bone marrow edema after 6 months without correlation to the clinical outcome (P = .06-.1). However, after 104 weeks, there were no differences in the radiological outcome between group A and group B. CONCLUSION: A rehabilitation protocol with accelerated weightbearing leads to good clinical and functional outcome after 2 years without jeopardizing the healing graft. SN - 1552-3365 UR - https://www.unboundmedicine.com/medline/citation/19846693/Effect_of_accelerated_weightbearing_after_matrix_associated_autologous_chondrocyte_implantation_on_the_femoral_condyle_on_radiographic_and_clinical_outcome_after_2_years:_a_prospective_randomized_controlled_pilot_study_ L2 - http://journals.sagepub.com/doi/full/10.1177/0363546509351272?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -