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Astaxanthin reduces oxidative stress, but not aortic damage in atherosclerotic rabbits.
J Cardiovasc Pharmacol Ther. 2009 Dec; 14(4):314-22.JC

Abstract

We evaluated whether carotenoid astaxanthin (ASX) could prevent oxidative and atherosclerotic damage in rabbits. Rabbits received regular chow (control) or an atherogenic diet (1% cholesterol) alone or supplemented with 50, 100, and 500 mg% ASX for 60 days (n = 5-9 per group). The atherogenic diet increased the serum cholesterol levels and the ratio of the intima/media area in the aortic arch. These changes were not prevented by ASX. Atherosclerotic rabbits showed increased aortic lipid peroxidation and nonprotein thiol group (NPSH) levels along with inhibition of glutathione peroxidase (GSH-Px). All ASX doses attenuated lipid peroxidation and the increase in NPSH but not the inhibition of GSH-Px. Aortic superoxide dismutase (SOD), catalase (CAT), and thioredoxin reductase (TrxR) activities were enhanced in atherosclerotic rabbits. Although all ASX doses prevented the increase in SOD activity, only 100 and 500 mg% ASX prevented the increase in CAT activity. Furthermore, these same doses partially prevented the increase in TrxR activity, while 50 mg% ASX completely prevented the effects of the atherogenic diet on this enzyme. However, ASX did not attenuate the hypercholesterolemia or the atherosclerotic lesions caused by the atherogenic diet at any of the doses evaluated. Our results indicate that although ASX did not prevent hypercholesterolemia or atherosclerotic lesions, it could play a beneficial role by preventing lipid peroxidation and changes in antioxidant enzyme activities.

Authors+Show Affiliations

Department of Biochemistry, Institute of Health Basic Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19846890

Citation

Augusti, Paula R., et al. "Astaxanthin Reduces Oxidative Stress, but Not Aortic Damage in Atherosclerotic Rabbits." Journal of Cardiovascular Pharmacology and Therapeutics, vol. 14, no. 4, 2009, pp. 314-22.
Augusti PR, Conterato GM, Somacal S, et al. Astaxanthin reduces oxidative stress, but not aortic damage in atherosclerotic rabbits. J Cardiovasc Pharmacol Ther. 2009;14(4):314-22.
Augusti, P. R., Conterato, G. M., Somacal, S., Sobieski, R., Quatrin, A., Maurer, L., Rocha, M. P., Denardin, I. T., & Emanuelli, T. (2009). Astaxanthin reduces oxidative stress, but not aortic damage in atherosclerotic rabbits. Journal of Cardiovascular Pharmacology and Therapeutics, 14(4), 314-22. https://doi.org/10.1177/1074248409350136
Augusti PR, et al. Astaxanthin Reduces Oxidative Stress, but Not Aortic Damage in Atherosclerotic Rabbits. J Cardiovasc Pharmacol Ther. 2009;14(4):314-22. PubMed PMID: 19846890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Astaxanthin reduces oxidative stress, but not aortic damage in atherosclerotic rabbits. AU - Augusti,Paula R, AU - Conterato,Greicy M M, AU - Somacal,Sabrina, AU - Sobieski,Rocheli, AU - Quatrin,Andréia, AU - Maurer,Luana, AU - Rocha,Marta P, AU - Denardin,Ione T, AU - Emanuelli,Tatiana, Y1 - 2009/10/21/ PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/1/16/medline SP - 314 EP - 22 JF - Journal of cardiovascular pharmacology and therapeutics JO - J Cardiovasc Pharmacol Ther VL - 14 IS - 4 N2 - We evaluated whether carotenoid astaxanthin (ASX) could prevent oxidative and atherosclerotic damage in rabbits. Rabbits received regular chow (control) or an atherogenic diet (1% cholesterol) alone or supplemented with 50, 100, and 500 mg% ASX for 60 days (n = 5-9 per group). The atherogenic diet increased the serum cholesterol levels and the ratio of the intima/media area in the aortic arch. These changes were not prevented by ASX. Atherosclerotic rabbits showed increased aortic lipid peroxidation and nonprotein thiol group (NPSH) levels along with inhibition of glutathione peroxidase (GSH-Px). All ASX doses attenuated lipid peroxidation and the increase in NPSH but not the inhibition of GSH-Px. Aortic superoxide dismutase (SOD), catalase (CAT), and thioredoxin reductase (TrxR) activities were enhanced in atherosclerotic rabbits. Although all ASX doses prevented the increase in SOD activity, only 100 and 500 mg% ASX prevented the increase in CAT activity. Furthermore, these same doses partially prevented the increase in TrxR activity, while 50 mg% ASX completely prevented the effects of the atherogenic diet on this enzyme. However, ASX did not attenuate the hypercholesterolemia or the atherosclerotic lesions caused by the atherogenic diet at any of the doses evaluated. Our results indicate that although ASX did not prevent hypercholesterolemia or atherosclerotic lesions, it could play a beneficial role by preventing lipid peroxidation and changes in antioxidant enzyme activities. SN - 1940-4034 UR - https://www.unboundmedicine.com/medline/citation/19846890/Astaxanthin_reduces_oxidative_stress_but_not_aortic_damage_in_atherosclerotic_rabbits_ L2 - https://journals.sagepub.com/doi/10.1177/1074248409350136?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -