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Impact of laparoscopic sleeve gastrectomy on iron indices: 1 year follow-up.
Obes Surg 2009; 19(11):1491-6OS

Abstract

BACKGROUND

Laparoscopic sleeve gastrectomy (LSG) has been recently introduced as a stand-alone, restrictive bariatric surgery. Theoretically, LSG attenuates micronutrients deficiencies and associated complications that typically observed following malabsorptive procedures. The aim of this study was to assess iron indices and the 1-year incidence of iron deficiency in patients undergoing LSG.

METHODS

This was a prospective, cohort study; patients who underwent LSG from June 2007 to April 2008 at our institution were screened for inclusion. Preoperative hemoglobin and iron indices including serum iron, transferrin saturation, ferritin, and soluble transferrin receptor were compared to their levels at 6 and 12 months after surgery. Similarly, vitamin B12 and red blood cell (RBC) folate were analyzed as secondary end points. Weight parameters and C-reactive protein (CRP) levels were compared before surgery and 1 year postoperatively.

RESULTS

A total of 61 patients were included in the study. One year after surgery, there was a significant decrease in the mean body mass index from 47.5 +/- 9.6 to 30.5 +/- 6.5 (P < 0.001). The incidence of iron deficiency was 4.9% at both follow-up time points. Anemia was evident in 4.9% of patients 1 year postoperatively. Significant decrease in the means of the natural logarithm of vitamin B12 and RBC folate were observed as early as 6 months after surgery (P = 0.014; P < 0.005, respectively). The decrease in mean CRP level 12 months postoperatively was statistically significant compared to its preoperative value (P < 0.0001).

CONCLUSION

LSG is an effective procedure for the treatment of morbid obesity and its associated inflammatory state. One year after surgery, development of iron deficiency was insignificant.

Authors+Show Affiliations

Pharmacy Services Division, King Faisal Specialist Hospital & Research Centre, PO Box 3354 MBC#11, Riyadh 11211, Saudi Arabia. hakeam@kfshrc.edu.saNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19847572

Citation

Hakeam, Hakeam A., et al. "Impact of Laparoscopic Sleeve Gastrectomy On Iron Indices: 1 Year Follow-up." Obesity Surgery, vol. 19, no. 11, 2009, pp. 1491-6.
Hakeam HA, O'Regan PJ, Salem AM, et al. Impact of laparoscopic sleeve gastrectomy on iron indices: 1 year follow-up. Obes Surg. 2009;19(11):1491-6.
Hakeam, H. A., O'Regan, P. J., Salem, A. M., Bamehriz, F. Y., & Eldali, A. M. (2009). Impact of laparoscopic sleeve gastrectomy on iron indices: 1 year follow-up. Obesity Surgery, 19(11), pp. 1491-6. doi:10.1007/s11695-009-9919-2.
Hakeam HA, et al. Impact of Laparoscopic Sleeve Gastrectomy On Iron Indices: 1 Year Follow-up. Obes Surg. 2009;19(11):1491-6. PubMed PMID: 19847572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of laparoscopic sleeve gastrectomy on iron indices: 1 year follow-up. AU - Hakeam,Hakeam A, AU - O'Regan,Patrick J, AU - Salem,Abdulrahman M, AU - Bamehriz,Fahad Y, AU - Eldali,Abdelmoneim M, Y1 - 2009/07/15/ PY - 2009/04/01/received PY - 2009/06/30/accepted PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/3/20/medline SP - 1491 EP - 6 JF - Obesity surgery JO - Obes Surg VL - 19 IS - 11 N2 - BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has been recently introduced as a stand-alone, restrictive bariatric surgery. Theoretically, LSG attenuates micronutrients deficiencies and associated complications that typically observed following malabsorptive procedures. The aim of this study was to assess iron indices and the 1-year incidence of iron deficiency in patients undergoing LSG. METHODS: This was a prospective, cohort study; patients who underwent LSG from June 2007 to April 2008 at our institution were screened for inclusion. Preoperative hemoglobin and iron indices including serum iron, transferrin saturation, ferritin, and soluble transferrin receptor were compared to their levels at 6 and 12 months after surgery. Similarly, vitamin B12 and red blood cell (RBC) folate were analyzed as secondary end points. Weight parameters and C-reactive protein (CRP) levels were compared before surgery and 1 year postoperatively. RESULTS: A total of 61 patients were included in the study. One year after surgery, there was a significant decrease in the mean body mass index from 47.5 +/- 9.6 to 30.5 +/- 6.5 (P < 0.001). The incidence of iron deficiency was 4.9% at both follow-up time points. Anemia was evident in 4.9% of patients 1 year postoperatively. Significant decrease in the means of the natural logarithm of vitamin B12 and RBC folate were observed as early as 6 months after surgery (P = 0.014; P < 0.005, respectively). The decrease in mean CRP level 12 months postoperatively was statistically significant compared to its preoperative value (P < 0.0001). CONCLUSION: LSG is an effective procedure for the treatment of morbid obesity and its associated inflammatory state. One year after surgery, development of iron deficiency was insignificant. SN - 1708-0428 UR - https://www.unboundmedicine.com/medline/citation/19847572/Impact_of_laparoscopic_sleeve_gastrectomy_on_iron_indices:_1_year_follow_up_ L2 - https://dx.doi.org/10.1007/s11695-009-9919-2 DB - PRIME DP - Unbound Medicine ER -