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Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels.
J Neuroimmune Pharmacol 2010; 5(1):103-21JN

Abstract

The molecular mechanism of action of Delta(9)-tetrahydrocannabinol (THC), the psychotropic constituent of Cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid CB1 and CB2 receptors. However, while these latter proteins do mediate most of the pharmacological actions of THC, they do not seem to act as receptors for other plant cannabinoids (phytocannabinoids), nor are they the unique targets of the endogenous lipids that were originally identified in animals as agonists of CB1 and CB2 receptors, and named endocannabinoids. Over the last decade, several potential alternative receptors for phytocannabinoids, endocannabinoids, and even synthetic cannabimimetics, have been proposed, often based uniquely on pharmacological evidence obtained in vitro. In particular, the endocannabinoid anandamide, and the other most abundant Cannabis constituent, cannabidiol, seem to be the most "promiscuous" of these compounds. In this article, we review the latest data on the non-CB1, non-CB2 receptors suggested so far for endocannabinoids and plant or synthetic cannabinoids, and lay special emphasis on uncharacterized or orphan G-protein-coupled receptors as well as on transient receptor potential channels.

Authors+Show Affiliations

Endocannabinoid Research Group, Institute of Cybernetics, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, NA, Italy.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19847654

Citation

De Petrocellis, Luciano, and Vincenzo Di Marzo. "Non-CB1, non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus On G-protein-coupled Receptors and Transient Receptor Potential Channels." Journal of Neuroimmune Pharmacology : the Official Journal of the Society On NeuroImmune Pharmacology, vol. 5, no. 1, 2010, pp. 103-21.
De Petrocellis L, Di Marzo V. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. J Neuroimmune Pharmacol. 2010;5(1):103-21.
De Petrocellis, L., & Di Marzo, V. (2010). Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On NeuroImmune Pharmacology, 5(1), pp. 103-21. doi:10.1007/s11481-009-9177-z.
De Petrocellis L, Di Marzo V. Non-CB1, non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus On G-protein-coupled Receptors and Transient Receptor Potential Channels. J Neuroimmune Pharmacol. 2010;5(1):103-21. PubMed PMID: 19847654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. AU - De Petrocellis,Luciano, AU - Di Marzo,Vincenzo, Y1 - 2009/10/22/ PY - 2009/08/11/received PY - 2009/09/24/accepted PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/5/12/medline SP - 103 EP - 21 JF - Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology JO - J Neuroimmune Pharmacol VL - 5 IS - 1 N2 - The molecular mechanism of action of Delta(9)-tetrahydrocannabinol (THC), the psychotropic constituent of Cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid CB1 and CB2 receptors. However, while these latter proteins do mediate most of the pharmacological actions of THC, they do not seem to act as receptors for other plant cannabinoids (phytocannabinoids), nor are they the unique targets of the endogenous lipids that were originally identified in animals as agonists of CB1 and CB2 receptors, and named endocannabinoids. Over the last decade, several potential alternative receptors for phytocannabinoids, endocannabinoids, and even synthetic cannabimimetics, have been proposed, often based uniquely on pharmacological evidence obtained in vitro. In particular, the endocannabinoid anandamide, and the other most abundant Cannabis constituent, cannabidiol, seem to be the most "promiscuous" of these compounds. In this article, we review the latest data on the non-CB1, non-CB2 receptors suggested so far for endocannabinoids and plant or synthetic cannabinoids, and lay special emphasis on uncharacterized or orphan G-protein-coupled receptors as well as on transient receptor potential channels. SN - 1557-1904 UR - https://www.unboundmedicine.com/medline/citation/19847654/abstract/Non_CB1_non_CB2_receptors L2 - https://doi.org/10.1007/s11481-009-9177-z DB - PRIME DP - Unbound Medicine ER -