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Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels.

Abstract

The molecular mechanism of action of Delta(9)-tetrahydrocannabinol (THC), the psychotropic constituent of Cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid CB1 and CB2 receptors. However, while these latter proteins do mediate most of the pharmacological actions of THC, they do not seem to act as receptors for other plant cannabinoids (phytocannabinoids), nor are they the unique targets of the endogenous lipids that were originally identified in animals as agonists of CB1 and CB2 receptors, and named endocannabinoids. Over the last decade, several potential alternative receptors for phytocannabinoids, endocannabinoids, and even synthetic cannabimimetics, have been proposed, often based uniquely on pharmacological evidence obtained in vitro. In particular, the endocannabinoid anandamide, and the other most abundant Cannabis constituent, cannabidiol, seem to be the most "promiscuous" of these compounds. In this article, we review the latest data on the non-CB1, non-CB2 receptors suggested so far for endocannabinoids and plant or synthetic cannabinoids, and lay special emphasis on uncharacterized or orphan G-protein-coupled receptors as well as on transient receptor potential channels.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Endocannabinoid Research Group, Institute of Cybernetics, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, NA, Italy.

    Source

    MeSH

    Animals
    Cannabinoid Receptor Modulators
    Cannabinoids
    Drug Evaluation, Preclinical
    Endocannabinoids
    Models, Biological
    Receptor, Cannabinoid, CB1
    Receptor, Cannabinoid, CB2
    Receptors, G-Protein-Coupled
    Transient Receptor Potential Channels

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19847654

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels. AU - De Petrocellis,Luciano, AU - Di Marzo,Vincenzo, Y1 - 2009/10/22/ PY - 2009/08/11/received PY - 2009/09/24/accepted PY - 2009/10/23/entrez PY - 2009/10/23/pubmed PY - 2010/5/12/medline SP - 103 EP - 21 JF - Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology JO - J Neuroimmune Pharmacol VL - 5 IS - 1 N2 - The molecular mechanism of action of Delta(9)-tetrahydrocannabinol (THC), the psychotropic constituent of Cannabis, has been a puzzle during the three decades separating its characterization, in 1964, and the cloning, in the 1990s, of cannabinoid CB1 and CB2 receptors. However, while these latter proteins do mediate most of the pharmacological actions of THC, they do not seem to act as receptors for other plant cannabinoids (phytocannabinoids), nor are they the unique targets of the endogenous lipids that were originally identified in animals as agonists of CB1 and CB2 receptors, and named endocannabinoids. Over the last decade, several potential alternative receptors for phytocannabinoids, endocannabinoids, and even synthetic cannabimimetics, have been proposed, often based uniquely on pharmacological evidence obtained in vitro. In particular, the endocannabinoid anandamide, and the other most abundant Cannabis constituent, cannabidiol, seem to be the most "promiscuous" of these compounds. In this article, we review the latest data on the non-CB1, non-CB2 receptors suggested so far for endocannabinoids and plant or synthetic cannabinoids, and lay special emphasis on uncharacterized or orphan G-protein-coupled receptors as well as on transient receptor potential channels. SN - 1557-1904 UR - https://www.unboundmedicine.com/medline/citation/19847654/abstract/Non_CB1_non_CB2_receptors_for_endocannabinoids_plant_cannabinoids_and_synthetic_cannabimimetics:_focus_on_G_protein_coupled_receptors_and_transient_receptor_potential_channels_ L2 - https://dx.doi.org/10.1007/s11481-009-9177-z DB - PRIME DP - Unbound Medicine ER -