Citation
Zheng, Yu Zhong, et al. "Ligustilide Suppresses the Biological Properties of Danggui Buxue Tang: a Chinese Herbal Decoction Composed of Radix Astragali and Radix Angelica Sinensis." Planta Medica, vol. 76, no. 5, 2010, pp. 439-43.
Zheng YZ, Choi RC, Li J, et al. Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. Planta Med. 2010;76(5):439-43.
Zheng, Y. Z., Choi, R. C., Li, J., Xie, H. Q., Cheung, A. W., Duan, R., Guo, A. J., Zhu, J. T., Chen, V. P., Bi, C. W., Zhu, Y., Lau, D. D., Dong, T. T., Lau, B. W., & Tsim, K. W. (2010). Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. Planta Medica, 76(5), 439-43. https://doi.org/10.1055/s-0029-1186222
Zheng YZ, et al. Ligustilide Suppresses the Biological Properties of Danggui Buxue Tang: a Chinese Herbal Decoction Composed of Radix Astragali and Radix Angelica Sinensis. Planta Med. 2010;76(5):439-43. PubMed PMID: 19847742.
TY - JOUR
T1 - Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
AU - Zheng,Yu Zhong,
AU - Choi,Roy Chi,
AU - Li,Jun,
AU - Xie,Heidi Qun,
AU - Cheung,Anna Wing,
AU - Duan,Ran,
AU - Guo,Ava Jiang,
AU - Zhu,Judy Ting,
AU - Chen,Vicky Ping,
AU - Bi,Cathy Wen,
AU - Zhu,Yue,
AU - Lau,David Dai,
AU - Dong,Tina Ting,
AU - Lau,Brad Wing,
AU - Tsim,Karl Wah,
Y1 - 2009/10/21/
PY - 2009/10/23/entrez
PY - 2009/10/23/pubmed
PY - 2010/6/5/medline
SP - 439
EP - 43
JF - Planta medica
JO - Planta Med
VL - 76
IS - 5
N2 - Danggui Buxue Tang (DBT), a herbal decoction composed of Radix Astragali (RA) and Radix Angelica sinensis (RAS), has been used for treating menopausal irregularity in women for more than 800 years in China. According to the old tradition, RAS had to be processed with yellow wine before DBT preparation, which markedly reduced the amount of ligustilide in RAS and DBT, as well as enhanced the bioactivities of DBT. Here, we hypothesized that ligustilide would be an ingredient that possessed suppressive effects on DBT's functions. In the presence of ligustilide, the amount of astragaloside IV, calycosin, formononetin, and total polysaccharides extracted from RA were decreased. An increase of ligustilide caused a decrease of DBT's osteogenic activity in stimulating proliferation and differentiation of cultured bone cells. In addition, in the presence of a high level of ligustilide, DBT caused a side effect inducing the proliferation of breast MCF-7 cells. The current results strongly suggest that ligustilide is a negative regulator that hinders DBT to achieve its biological efficacy, which supports the traditional practice of preparing DBT using the ethanol-treated RAS.
SN - 1439-0221
UR - https://www.unboundmedicine.com/medline/citation/19847742/Ligustilide_suppresses_the_biological_properties_of_Danggui_Buxue_Tang:_a_Chinese_herbal_decoction_composed_of_radix_astragali_and_radix_angelica_sinensis_
L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1186222
DB - PRIME
DP - Unbound Medicine
ER -
