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Randomized controlled trial of mindfulness-based therapy for dyspnea in chronic obstructive lung disease.
J Altern Complement Med. 2009 Oct; 15(10):1083-90.JA

Abstract

OBJECTIVES

Patients with chronic obstructive lung disease (COPD) suffer from significant dyspnea and may benefit from complementary and alternative medicine (CAM) therapies aimed at mitigating symptoms. The objective of this study was to test the efficacy of a mindfulness-based breathing therapy (MBBT) on improving symptoms and health-related quality of life in those with COPD.

DESIGN

We conducted a randomized controlled trial of 8-week mindfulness-based breathing therapy (MBBT) compared to support groups to test efficacy on improving symptoms and health-related quality of life in those with COPD.

SETTING

The setting for this study was an academic-affiliated veterans healthcare system.

SUBJECTS

The subjects consisted of 86 patients with COPD.

INTERVENTIONS

MBBT included weekly meetings practicing mindfulness mediation and relaxation response.

OUTCOME MEASURES

The main outcome measure was a post 6-minute-walk test (6MWT) Borg dyspnea assessment. Other outcome measures included health-related quality of life measures, 6MWT distance, symptom scores, exacerbation rates, and measures of stress and mindfulness. Analysis of covariance compared differences in outcomes between groups; paired t test evaluated changes within groups.

RESULTS

Participants were predominantly elderly men with moderate to severe COPD. We found no improvements in dyspnea (post 6MWT Borg difference between the MBBT and support group was 0.3 (95% confidence interval [CI]: -1.1, 1.7). We found no differences between groups in almost all other outcome measures by either intention-to-treat analysis or within the subset that completed assigned group sessions. For the physical summary scale of the generic Short Form-36 for Veterans, the difference between outcomes favored the support group (4.3, 95% CI: 0.4, 8.1). Participant retention was low compared to mind-body trials that randomize from CAM wait lists.

CONCLUSIONS

This trial found no measurable improvements in patients with COPD receiving a mindfulness-based breathing CAM therapy compared to a support group, suggesting that this intervention is unlikely to be an important therapeutic option for those with moderate-to-severe COPD.

Links

Publisher Full Text

Authors+Show Affiliations

Mularski RA
The Center for Health Research , Kaiser Permanente Northwest, Portland, OR 97227, USA. Richard.A.Mularski@kpchr.org
Munjas BA
No affiliation info available
Lorenz KA
No affiliation info available
Sun S
No affiliation info available
Robertson SJ
No affiliation info available
Schmelzer W
No affiliation info available
Kim AC
No affiliation info available
Shekelle PG
No affiliation info available

MeSH

AgedAged, 80 and overAnalysis of VarianceBreathing ExercisesDyspneaFemaleHumansIntention to Treat AnalysisMaleMeditationMiddle AgedPulmonary Disease, Chronic ObstructiveQuality of LifeRelaxation TherapySeverity of Illness IndexStress, PsychologicalWalking

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19848546

Clinical Trial Links

Clinical trial which this article describes
Mindfulness-based Intervention in COPD Dyads

Citation

Mularski, Richard A., et al. "Randomized Controlled Trial of Mindfulness-based Therapy for Dyspnea in Chronic Obstructive Lung Disease." Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 15, no. 10, 2009, pp. 1083-90.
Mularski RA, Munjas BA, Lorenz KA, et al. Randomized controlled trial of mindfulness-based therapy for dyspnea in chronic obstructive lung disease. J Altern Complement Med. 2009;15(10):1083-90.
Mularski, R. A., Munjas, B. A., Lorenz, K. A., Sun, S., Robertson, S. J., Schmelzer, W., Kim, A. C., & Shekelle, P. G. (2009). Randomized controlled trial of mindfulness-based therapy for dyspnea in chronic obstructive lung disease. Journal of Alternative and Complementary Medicine (New York, N.Y.), 15(10), 1083-90. https://doi.org/10.1089/acm.2009.0037
Mularski RA, et al. Randomized Controlled Trial of Mindfulness-based Therapy for Dyspnea in Chronic Obstructive Lung Disease. J Altern Complement Med. 2009;15(10):1083-90. PubMed PMID: 19848546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized controlled trial of mindfulness-based therapy for dyspnea in chronic obstructive lung disease. AU - Mularski,Richard A, AU - Munjas,Brett A, AU - Lorenz,Karl A, AU - Sun,Su, AU - Robertson,Sandra J, AU - Schmelzer,Wendy, AU - Kim,Adina C, AU - Shekelle,Paul G, PY - 2009/10/24/entrez PY - 2009/10/24/pubmed PY - 2010/2/13/medline SP - 1083 EP - 90 JF - Journal of alternative and complementary medicine (New York, N.Y.) JO - J Altern Complement Med VL - 15 IS - 10 N2 - OBJECTIVES: Patients with chronic obstructive lung disease (COPD) suffer from significant dyspnea and may benefit from complementary and alternative medicine (CAM) therapies aimed at mitigating symptoms. The objective of this study was to test the efficacy of a mindfulness-based breathing therapy (MBBT) on improving symptoms and health-related quality of life in those with COPD. DESIGN: We conducted a randomized controlled trial of 8-week mindfulness-based breathing therapy (MBBT) compared to support groups to test efficacy on improving symptoms and health-related quality of life in those with COPD. SETTING: The setting for this study was an academic-affiliated veterans healthcare system. SUBJECTS: The subjects consisted of 86 patients with COPD. INTERVENTIONS: MBBT included weekly meetings practicing mindfulness mediation and relaxation response. OUTCOME MEASURES: The main outcome measure was a post 6-minute-walk test (6MWT) Borg dyspnea assessment. Other outcome measures included health-related quality of life measures, 6MWT distance, symptom scores, exacerbation rates, and measures of stress and mindfulness. Analysis of covariance compared differences in outcomes between groups; paired t test evaluated changes within groups. RESULTS: Participants were predominantly elderly men with moderate to severe COPD. We found no improvements in dyspnea (post 6MWT Borg difference between the MBBT and support group was 0.3 (95% confidence interval [CI]: -1.1, 1.7). We found no differences between groups in almost all other outcome measures by either intention-to-treat analysis or within the subset that completed assigned group sessions. For the physical summary scale of the generic Short Form-36 for Veterans, the difference between outcomes favored the support group (4.3, 95% CI: 0.4, 8.1). Participant retention was low compared to mind-body trials that randomize from CAM wait lists. CONCLUSIONS: This trial found no measurable improvements in patients with COPD receiving a mindfulness-based breathing CAM therapy compared to a support group, suggesting that this intervention is unlikely to be an important therapeutic option for those with moderate-to-severe COPD. SN - 1557-7708 UR - https://www.unboundmedicine.com/medline/citation/19848546/Randomized_controlled_trial_of_mindfulness_based_therapy_for_dyspnea_in_chronic_obstructive_lung_disease_ L2 - https://www.liebertpub.com/doi/10.1089/acm.2009.0037?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -