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Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis.
Br J Dermatol. 2010 Jan; 162(1):159-61.BJ

Abstract

Background A significant proportion of young children with atopic dermatitis (AD) is sensitized to microbial allergens, which play a potential role in the pathogenesis of AD inflammation. Objective To study the timing of IgE sensitization to microbial allergens including staphylococcal superantigens, Malassezia species and Candida albicans in young children with AD. Method Specific IgE antibodies to staphylococcal superantigens, Malassezia species, C. albicans and control inhalant/food allergens were measured in 53 young children with mild to moderate AD. The presence of IgE sensitization relative to age (> or = 3 years vs. < 3 years) was analysed by logistic regressions. Results IgE sensitization to the staphylococcal superantigen group, Malassezia species and C. albicans was significantly associated with older age in children with AD [P = 0.02, odds ratio (OR) 4.9; P = 0.02, OR 4.7; and P = 0.05, OR 4.0, respectively]. Conclusion IgE sensitization to microbial allergens is associated with an older age group in young children with mild to moderate AD.

Authors+Show Affiliations

Division of Clinical Immunology and Allergy, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS# 75, Los Angeles, CA 90027, USA. pyong@chla.usc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19849698

Citation

Ong, P Y., et al. "Late-onset of IgE Sensitization to Microbial Allergens in Young Children With Atopic Dermatitis." The British Journal of Dermatology, vol. 162, no. 1, 2010, pp. 159-61.
Ong PY, Ferdman RM, Church JA. Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis. Br J Dermatol. 2010;162(1):159-61.
Ong, P. Y., Ferdman, R. M., & Church, J. A. (2010). Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis. The British Journal of Dermatology, 162(1), 159-61. https://doi.org/10.1111/j.1365-2133.2009.09501.x
Ong PY, Ferdman RM, Church JA. Late-onset of IgE Sensitization to Microbial Allergens in Young Children With Atopic Dermatitis. Br J Dermatol. 2010;162(1):159-61. PubMed PMID: 19849698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Late-onset of IgE sensitization to microbial allergens in young children with atopic dermatitis. AU - Ong,P Y, AU - Ferdman,R M, AU - Church,J A, Y1 - 2009/09/08/ PY - 2009/10/24/entrez PY - 2009/10/24/pubmed PY - 2010/5/25/medline SP - 159 EP - 61 JF - The British journal of dermatology JO - Br J Dermatol VL - 162 IS - 1 N2 - Background A significant proportion of young children with atopic dermatitis (AD) is sensitized to microbial allergens, which play a potential role in the pathogenesis of AD inflammation. Objective To study the timing of IgE sensitization to microbial allergens including staphylococcal superantigens, Malassezia species and Candida albicans in young children with AD. Method Specific IgE antibodies to staphylococcal superantigens, Malassezia species, C. albicans and control inhalant/food allergens were measured in 53 young children with mild to moderate AD. The presence of IgE sensitization relative to age (> or = 3 years vs. < 3 years) was analysed by logistic regressions. Results IgE sensitization to the staphylococcal superantigen group, Malassezia species and C. albicans was significantly associated with older age in children with AD [P = 0.02, odds ratio (OR) 4.9; P = 0.02, OR 4.7; and P = 0.05, OR 4.0, respectively]. Conclusion IgE sensitization to microbial allergens is associated with an older age group in young children with mild to moderate AD. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/19849698/Late_onset_of_IgE_sensitization_to_microbial_allergens_in_young_children_with_atopic_dermatitis_ DB - PRIME DP - Unbound Medicine ER -