Tags

Type your tag names separated by a space and hit enter

Metered dose inhalers for bronchodilator delivery in intubated, mechanically ventilated patients.
Chest. 1991 Jan; 99(1):66-71.Chest

Abstract

We determined the relative efficacy of two bronchodilator aerosol delivery methods in 18 intubated mechanically ventilated patients with airways obstruction. Two treatment arms, consisting of albuterol 270 micrograms (three puffs) from a metered dose inhaler and albuterol 2.5 mg from a saline solution nebulized with an updraft inhaler, were compared in a single blind, randomized crossover design. Pulmonary function was evaluated using an interrupter technique. Changes in passive expiratory flow at respiratory system recoil pressures between 6 and 10 cm H2O provided the therapeutic endpoints. Paired measurements were made before and 30 minutes after drug delivery. The MDI and NEB resulted in similar improvements in iso-recoil flow (mean increase for both groups = 0.1 L/s). Treatment sequence, severity of obstruction, and bronchodilator responsiveness had no effect on relative efficacy. Albuterol caused a small but significant increase in heart rate that was similar following both delivery methods. We conclude that bronchodilator aerosol delivery with metered dose inhalers provides a viable alternative to nebulizer therapy in intubated mechanically ventilated patients and may result in a cost savings to hospitals and patients.

Authors+Show Affiliations

Department of Internal Medicine and Thoracic Diseases, Mayo Graduate School of Medicine, Rochester, MN 55905.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1984989

Citation

Gay, P C., et al. "Metered Dose Inhalers for Bronchodilator Delivery in Intubated, Mechanically Ventilated Patients." Chest, vol. 99, no. 1, 1991, pp. 66-71.
Gay PC, Patel HG, Nelson SB, et al. Metered dose inhalers for bronchodilator delivery in intubated, mechanically ventilated patients. Chest. 1991;99(1):66-71.
Gay, P. C., Patel, H. G., Nelson, S. B., Gilles, B., & Hubmayr, R. D. (1991). Metered dose inhalers for bronchodilator delivery in intubated, mechanically ventilated patients. Chest, 99(1), 66-71.
Gay PC, et al. Metered Dose Inhalers for Bronchodilator Delivery in Intubated, Mechanically Ventilated Patients. Chest. 1991;99(1):66-71. PubMed PMID: 1984989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metered dose inhalers for bronchodilator delivery in intubated, mechanically ventilated patients. AU - Gay,P C, AU - Patel,H G, AU - Nelson,S B, AU - Gilles,B, AU - Hubmayr,R D, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 66 EP - 71 JF - Chest JO - Chest VL - 99 IS - 1 N2 - We determined the relative efficacy of two bronchodilator aerosol delivery methods in 18 intubated mechanically ventilated patients with airways obstruction. Two treatment arms, consisting of albuterol 270 micrograms (three puffs) from a metered dose inhaler and albuterol 2.5 mg from a saline solution nebulized with an updraft inhaler, were compared in a single blind, randomized crossover design. Pulmonary function was evaluated using an interrupter technique. Changes in passive expiratory flow at respiratory system recoil pressures between 6 and 10 cm H2O provided the therapeutic endpoints. Paired measurements were made before and 30 minutes after drug delivery. The MDI and NEB resulted in similar improvements in iso-recoil flow (mean increase for both groups = 0.1 L/s). Treatment sequence, severity of obstruction, and bronchodilator responsiveness had no effect on relative efficacy. Albuterol caused a small but significant increase in heart rate that was similar following both delivery methods. We conclude that bronchodilator aerosol delivery with metered dose inhalers provides a viable alternative to nebulizer therapy in intubated mechanically ventilated patients and may result in a cost savings to hospitals and patients. SN - 0012-3692 UR - https://www.unboundmedicine.com/medline/citation/1984989/Metered_dose_inhalers_for_bronchodilator_delivery_in_intubated_mechanically_ventilated_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(16)30246-X DB - PRIME DP - Unbound Medicine ER -