Tags

Type your tag names separated by a space and hit enter

Micronutrient deficiencies an unmet need in heart failure.
J Am Coll Cardiol 2009; 54(18):1660-73JACC

Abstract

Heart failure (HF) is a common, disabling, and costly disease. Despite major advances in medical therapy, morbidity and mortality remain high, in part because current pharmacological regimens may not fully address some unique requirements of the heart for energy. The heart requires a continuous supply of energy-providing substrates and amino acids in order to maintain its function. In HF, defects in substrate metabolism and cardiac energy and substrate utilization may contribute to contractile dysfunction. HF is often accompanied by a deficiency in key micronutrients required for unimpeded energy transfer. Correcting these deficits has been proposed as a method to limit or even reverse the progressive myocyte dysfunction and/or necrosis in HF. This review summarizes the existing HF literature with respect to supplementation trials of key micronutrients involved in cardiac metabolism: coenzyme Q10, l-carnitine, thiamine, and amino acids, including taurine. Studies using a broader approach to supplementation are also considered. Although some of the results are promising, none are conclusive. There is a need for a prospective trial to examine the effects of micronutrient supplementation on morbidity and mortality in patients with HF.

Authors+Show Affiliations

Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19850206

Citation

Soukoulis, Victor, et al. "Micronutrient Deficiencies an Unmet Need in Heart Failure." Journal of the American College of Cardiology, vol. 54, no. 18, 2009, pp. 1660-73.
Soukoulis V, Dihu JB, Sole M, et al. Micronutrient deficiencies an unmet need in heart failure. J Am Coll Cardiol. 2009;54(18):1660-73.
Soukoulis, V., Dihu, J. B., Sole, M., Anker, S. D., Cleland, J., Fonarow, G. C., ... Gheorghiade, M. (2009). Micronutrient deficiencies an unmet need in heart failure. Journal of the American College of Cardiology, 54(18), pp. 1660-73. doi:10.1016/j.jacc.2009.08.012.
Soukoulis V, et al. Micronutrient Deficiencies an Unmet Need in Heart Failure. J Am Coll Cardiol. 2009 Oct 27;54(18):1660-73. PubMed PMID: 19850206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Micronutrient deficiencies an unmet need in heart failure. AU - Soukoulis,Victor, AU - Dihu,Jamil B, AU - Sole,Michael, AU - Anker,Stefan D, AU - Cleland,John, AU - Fonarow,Gregg C, AU - Metra,Marco, AU - Pasini,Evasio, AU - Strzelczyk,Theresa, AU - Taegtmeyer,Heinrich, AU - Gheorghiade,Mihai, PY - 2009/07/16/received PY - 2009/08/24/revised PY - 2009/08/25/accepted PY - 2009/10/24/entrez PY - 2009/10/24/pubmed PY - 2009/11/11/medline SP - 1660 EP - 73 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 54 IS - 18 N2 - Heart failure (HF) is a common, disabling, and costly disease. Despite major advances in medical therapy, morbidity and mortality remain high, in part because current pharmacological regimens may not fully address some unique requirements of the heart for energy. The heart requires a continuous supply of energy-providing substrates and amino acids in order to maintain its function. In HF, defects in substrate metabolism and cardiac energy and substrate utilization may contribute to contractile dysfunction. HF is often accompanied by a deficiency in key micronutrients required for unimpeded energy transfer. Correcting these deficits has been proposed as a method to limit or even reverse the progressive myocyte dysfunction and/or necrosis in HF. This review summarizes the existing HF literature with respect to supplementation trials of key micronutrients involved in cardiac metabolism: coenzyme Q10, l-carnitine, thiamine, and amino acids, including taurine. Studies using a broader approach to supplementation are also considered. Although some of the results are promising, none are conclusive. There is a need for a prospective trial to examine the effects of micronutrient supplementation on morbidity and mortality in patients with HF. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/19850206/Micronutrient_deficiencies_an_unmet_need_in_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(09)02797-1 DB - PRIME DP - Unbound Medicine ER -