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MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study.
J Sci Med Sport 2010; 13(5):526-30JS

Abstract

Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. A common polymorphic MCT1 variant has been identified, but its role in high intensity exercise performance has not been defined. We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on lactate accumulation after high intensity circuit training. Ten men aged 20-26 performed three controlled circuit training (CWT) sessions at 60%, 70%, and 80% of the 15 repetition maximum (15RM), in non-consecutive days. CWT included three sets of a circuit of eight exercises, obtaining lactate measurements immediately after each set had been completed. Two independent variables were analysed: MTC1 genotypes according to the presence or absence of the A1470T polymorphism, and the intensity of circuit training. Genotype distributions were in Hardy-Weinberg equilibrium, being 30% wild-type, 50% heterozygotes, and 20% mutated homozygotes. Mean lactate concentration at 80% of 15RM were significantly higher than the mean lactate values at the other intensities (p<0.01). Significant differences between genetic groups were found in the lactate accumulation slope at 80% of 15RM (p=0.02) and in the maximal lactate concentration reached by all subjects in the study (L(max)) (p=0.03). The carriers of the A1470T polymorphism in the MTC1 gene seem to exhibit a worse lactate transport capability into the less active muscle cells for oxidation.

Authors+Show Affiliations

Laboratory of Exercise Physiology, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19850519

Citation

Cupeiro, Rocío, et al. "MCT1 Genetic Polymorphism Influence in High Intensity Circuit Training: a Pilot Study." Journal of Science and Medicine in Sport, vol. 13, no. 5, 2010, pp. 526-30.
Cupeiro R, Benito PJ, Maffulli N, et al. MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. J Sci Med Sport. 2010;13(5):526-30.
Cupeiro, R., Benito, P. J., Maffulli, N., Calderón, F. J., & González-Lamuño, D. (2010). MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. Journal of Science and Medicine in Sport, 13(5), pp. 526-30. doi:10.1016/j.jsams.2009.07.004.
Cupeiro R, et al. MCT1 Genetic Polymorphism Influence in High Intensity Circuit Training: a Pilot Study. J Sci Med Sport. 2010;13(5):526-30. PubMed PMID: 19850519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. AU - Cupeiro,Rocío, AU - Benito,Pedro J, AU - Maffulli,Nicola, AU - Calderón,F Javier, AU - González-Lamuño,Domingo, Y1 - 2009/10/22/ PY - 2009/05/06/received PY - 2009/07/05/revised PY - 2009/07/21/accepted PY - 2009/10/24/entrez PY - 2009/10/24/pubmed PY - 2010/12/14/medline SP - 526 EP - 30 JF - Journal of science and medicine in sport JO - J Sci Med Sport VL - 13 IS - 5 N2 - Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. A common polymorphic MCT1 variant has been identified, but its role in high intensity exercise performance has not been defined. We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on lactate accumulation after high intensity circuit training. Ten men aged 20-26 performed three controlled circuit training (CWT) sessions at 60%, 70%, and 80% of the 15 repetition maximum (15RM), in non-consecutive days. CWT included three sets of a circuit of eight exercises, obtaining lactate measurements immediately after each set had been completed. Two independent variables were analysed: MTC1 genotypes according to the presence or absence of the A1470T polymorphism, and the intensity of circuit training. Genotype distributions were in Hardy-Weinberg equilibrium, being 30% wild-type, 50% heterozygotes, and 20% mutated homozygotes. Mean lactate concentration at 80% of 15RM were significantly higher than the mean lactate values at the other intensities (p<0.01). Significant differences between genetic groups were found in the lactate accumulation slope at 80% of 15RM (p=0.02) and in the maximal lactate concentration reached by all subjects in the study (L(max)) (p=0.03). The carriers of the A1470T polymorphism in the MTC1 gene seem to exhibit a worse lactate transport capability into the less active muscle cells for oxidation. SN - 1878-1861 UR - https://www.unboundmedicine.com/medline/citation/19850519/MCT1_genetic_polymorphism_influence_in_high_intensity_circuit_training:_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1440-2440(09)00183-2 DB - PRIME DP - Unbound Medicine ER -