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Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety.
Audiol Neurootol. 2010; 15(3):187-93.AN

Abstract

We evaluated the effects of a selective serotonin reuptake inhibitor, paroxetine, on treating tinnitus.Tinnitus patients stratified for the presence of depression and anxiety were studied retrospectively. Fifty-six patients were observed for more than 6 months. They were initially treated with paroxetine only at a dose of 10 mg/day for 2-4 weeks; thereafter, the dose was increased to 20 mg/day. Tinnitus distress was evaluated with the Tinnitus Handicap Inventory (THI) and with visual analog scales (VASs) for tinnitus loudness and annoyance. Depression and anxiety were measured with the Self-Rating Depression Scale (SDS) and the trait section of the State-Trait Anxiety Inventory (STAI). The patients were grouped according to their SDS and STAI scores, and each variable was compared at baseline and the 6-month follow-up. Changes among these variables were also examined to determine whether reduced tinnitus distress was related to the improvement of depression or anxiety. Patients with both depression and anxiety showed better results (decrease in THI, VASs, SDS and STAI scores) than patients with anxiety alone, or patients without depression and anxiety. In patients with depression and anxiety, changes in tinnitus variables and changes in depression and anxiety scores were strongly correlated. In other patients, however, changes in tinnitus variables and changes in depression and anxiety scores were not correlated. These results suggest that paroxetine is effective in treating distressed tinnitus patients with depression and anxiety by reducing their tinnitus severity as well as their depression and anxiety.

Authors+Show Affiliations

Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan. o-ishi@mub.biglobe.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19851065

Citation

Oishi, Naoki, et al. "Effects of Selective Serotonin Reuptake Inhibitor On Treating Tinnitus in Patients Stratified for Presence of Depression or Anxiety." Audiology & Neuro-otology, vol. 15, no. 3, 2010, pp. 187-93.
Oishi N, Kanzaki S, Shinden S, et al. Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety. Audiol Neurootol. 2010;15(3):187-93.
Oishi, N., Kanzaki, S., Shinden, S., Saito, H., Inoue, Y., & Ogawa, K. (2010). Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety. Audiology & Neuro-otology, 15(3), 187-93. https://doi.org/10.1159/000251916
Oishi N, et al. Effects of Selective Serotonin Reuptake Inhibitor On Treating Tinnitus in Patients Stratified for Presence of Depression or Anxiety. Audiol Neurootol. 2010;15(3):187-93. PubMed PMID: 19851065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety. AU - Oishi,Naoki, AU - Kanzaki,Sho, AU - Shinden,Seiichi, AU - Saito,Hideyuki, AU - Inoue,Yasuhiro, AU - Ogawa,Kaoru, Y1 - 2009/10/23/ PY - 2009/01/29/received PY - 2009/07/16/accepted PY - 2009/10/24/entrez PY - 2009/10/24/pubmed PY - 2010/7/8/medline SP - 187 EP - 93 JF - Audiology & neuro-otology JO - Audiol Neurootol VL - 15 IS - 3 N2 - We evaluated the effects of a selective serotonin reuptake inhibitor, paroxetine, on treating tinnitus.Tinnitus patients stratified for the presence of depression and anxiety were studied retrospectively. Fifty-six patients were observed for more than 6 months. They were initially treated with paroxetine only at a dose of 10 mg/day for 2-4 weeks; thereafter, the dose was increased to 20 mg/day. Tinnitus distress was evaluated with the Tinnitus Handicap Inventory (THI) and with visual analog scales (VASs) for tinnitus loudness and annoyance. Depression and anxiety were measured with the Self-Rating Depression Scale (SDS) and the trait section of the State-Trait Anxiety Inventory (STAI). The patients were grouped according to their SDS and STAI scores, and each variable was compared at baseline and the 6-month follow-up. Changes among these variables were also examined to determine whether reduced tinnitus distress was related to the improvement of depression or anxiety. Patients with both depression and anxiety showed better results (decrease in THI, VASs, SDS and STAI scores) than patients with anxiety alone, or patients without depression and anxiety. In patients with depression and anxiety, changes in tinnitus variables and changes in depression and anxiety scores were strongly correlated. In other patients, however, changes in tinnitus variables and changes in depression and anxiety scores were not correlated. These results suggest that paroxetine is effective in treating distressed tinnitus patients with depression and anxiety by reducing their tinnitus severity as well as their depression and anxiety. SN - 1421-9700 UR - https://www.unboundmedicine.com/medline/citation/19851065/Effects_of_selective_serotonin_reuptake_inhibitor_on_treating_tinnitus_in_patients_stratified_for_presence_of_depression_or_anxiety_ L2 - https://www.karger.com?DOI=10.1159/000251916 DB - PRIME DP - Unbound Medicine ER -