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Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy.
World J Surg Oncol. 2009 Oct 23; 7:77.WJ

Abstract

BACKGROUND

Percutaneous core needle biopsy (CNB) is considered to be the standard technique for histological diagnosis of breast lesions. But, it is less reliable for diagnosing atypical ductal hyperplasia (ADH). The purpose of the present study was to predict, based on clinical and radiological findings, which cases of ADH diagnosed by CNB would be more likely to be associated with a more advanced lesion on subsequent surgical excision.

METHODS

Between February 2002 and December 2007, consecutive ultrasound-guided CNBs were performed on suspicious breast lesions at Seoul St. Mary's Hospital. A total of 69 CNBs led to a diagnosis of ADH, and 45 patients underwent follow-up surgical excision. We reviewed the medical records and analyses retrospectively.

RESULTS

Sixty-nine patients were diagnosed with ADH at CNB. Of these patients, 45 underwent surgical excision and 10 (22.2%) were subsequently diagnosed with a malignancy (ductal carcinoma in situ, n = 8; invasive cancer, n = 2). Univariate analysis revealed age (>or= 50-years) at the time of core needle biopsy (p = 0.006), size (> 10 mm) on imaging (p = 0.033), and combined mass with microcalcification on sonography (p = 0.029) to be associated with underestimation. When those three factors were included in multivariate analysis, only age (p = 0.035, HR 6.201, 95% CI 1.135-33.891) was an independent predictor of malignancy.

CONCLUSION

Age (>or= 50) at the time of biopsy is an independent predictive factor for breast cancer at surgical excision in patients with diagnosed ADH at CNB. For patients diagnosed with ADH at CNB, only complete surgical excision is the suitable treatment option, because we could not find any combination of factors that can safely predict the absence of DCIS or invasive cancer in a case of ADH.

Authors+Show Affiliations

Department of Surgery, Catholic University of Korea, Seoul, Korea. bjchae@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19852801

Citation

Chae, Byung Joo, et al. "Predictive Factors for Breast Cancer in Patients Diagnosed Atypical Ductal Hyperplasia at Core Needle Biopsy." World Journal of Surgical Oncology, vol. 7, 2009, p. 77.
Chae BJ, Lee A, Song BJ, et al. Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy. World J Surg Oncol. 2009;7:77.
Chae, B. J., Lee, A., Song, B. J., & Jung, S. S. (2009). Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy. World Journal of Surgical Oncology, 7, 77. https://doi.org/10.1186/1477-7819-7-77
Chae BJ, et al. Predictive Factors for Breast Cancer in Patients Diagnosed Atypical Ductal Hyperplasia at Core Needle Biopsy. World J Surg Oncol. 2009 Oct 23;7:77. PubMed PMID: 19852801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive factors for breast cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy. AU - Chae,Byung Joo, AU - Lee,Ahwon, AU - Song,Byung Joo, AU - Jung,Sang Seol, Y1 - 2009/10/23/ PY - 2009/07/05/received PY - 2009/10/23/accepted PY - 2009/10/27/entrez PY - 2009/10/27/pubmed PY - 2010/1/5/medline SP - 77 EP - 77 JF - World journal of surgical oncology JO - World J Surg Oncol VL - 7 N2 - BACKGROUND: Percutaneous core needle biopsy (CNB) is considered to be the standard technique for histological diagnosis of breast lesions. But, it is less reliable for diagnosing atypical ductal hyperplasia (ADH). The purpose of the present study was to predict, based on clinical and radiological findings, which cases of ADH diagnosed by CNB would be more likely to be associated with a more advanced lesion on subsequent surgical excision. METHODS: Between February 2002 and December 2007, consecutive ultrasound-guided CNBs were performed on suspicious breast lesions at Seoul St. Mary's Hospital. A total of 69 CNBs led to a diagnosis of ADH, and 45 patients underwent follow-up surgical excision. We reviewed the medical records and analyses retrospectively. RESULTS: Sixty-nine patients were diagnosed with ADH at CNB. Of these patients, 45 underwent surgical excision and 10 (22.2%) were subsequently diagnosed with a malignancy (ductal carcinoma in situ, n = 8; invasive cancer, n = 2). Univariate analysis revealed age (>or= 50-years) at the time of core needle biopsy (p = 0.006), size (> 10 mm) on imaging (p = 0.033), and combined mass with microcalcification on sonography (p = 0.029) to be associated with underestimation. When those three factors were included in multivariate analysis, only age (p = 0.035, HR 6.201, 95% CI 1.135-33.891) was an independent predictor of malignancy. CONCLUSION: Age (>or= 50) at the time of biopsy is an independent predictive factor for breast cancer at surgical excision in patients with diagnosed ADH at CNB. For patients diagnosed with ADH at CNB, only complete surgical excision is the suitable treatment option, because we could not find any combination of factors that can safely predict the absence of DCIS or invasive cancer in a case of ADH. SN - 1477-7819 UR - https://www.unboundmedicine.com/medline/citation/19852801/Predictive_factors_for_breast_cancer_in_patients_diagnosed_atypical_ductal_hyperplasia_at_core_needle_biopsy_ L2 - https://wjso.biomedcentral.com/articles/10.1186/1477-7819-7-77 DB - PRIME DP - Unbound Medicine ER -