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Low- and high-density lipoprotein cholesterol goal attainment in dyslipidemic women: The Lipid Treatment Assessment Project (L-TAP) 2.
Am Heart J 2009; 158(5):860-6AH

Abstract

BACKGROUND

Differences between women and men have been documented for both diagnostic testing and treatment in cardiology. This analysis evaluates whether low-density lipoprotein cholesterol (LDL-C) success rates according to current guidelines and high-density lipoprotein cholesterol (HDL-C) levels differ by gender in the L-TAP 2 population.

METHODS

Patients aged > or =20 years with dyslipidemia on stable lipid-lowering therapy were assessed in 9 countries between September 2006 and April 2007. Low-density lipoprotein cholesterol goal attainment by cardiovascular risk level and region and determinants of low HDL-C were compared between genders.

RESULTS

Of 9,955 patients (45.3% women) evaluated, women had a significantly lower overall LDL-C success rate than men (71.5% vs 73.7%, P = .014), due entirely to the difference in the high-risk/coronary heart disease (CHD) group (LDL-C goal <100 mg/dL, 62.6% vs 70.6%, P < .0001) Among CHD patients with > or =2 additional risk factors, only 26.7% of women and 31.5% of men (P = .021) attained the optional LDL-C goal of <70 mg/dL. High-density lipoprotein cholesterol was <50 mg/dL in 32.2% of women and <40 mg/dL in 26.8% of men (P < .0001), including 38.2% of women and 29.8% of men in the high risk/CHD group (P < .0001). Predictors of low HDL-C in women included diabetes, smoking, waist circumference, and hypertension.

CONCLUSIONS

Cholesterol treatment has improved substantially since the original L-TAP a decade ago, when only 39% of women attained their LDL-C goal. However, high-risk women are undertreated compared to men, and a substantial opportunity remains to reduce their cardiovascular risk.

Authors+Show Affiliations

Lipid Clinic, Heart Institute, University of São Paulo Hospital, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19853709

Citation

Santos, Raul D., et al. "Low- and High-density Lipoprotein Cholesterol Goal Attainment in Dyslipidemic Women: the Lipid Treatment Assessment Project (L-TAP) 2." American Heart Journal, vol. 158, no. 5, 2009, pp. 860-6.
Santos RD, Waters DD, Tarasenko L, et al. Low- and high-density lipoprotein cholesterol goal attainment in dyslipidemic women: The Lipid Treatment Assessment Project (L-TAP) 2. Am Heart J. 2009;158(5):860-6.
Santos, R. D., Waters, D. D., Tarasenko, L., Messig, M., Jukema, J. W., Ferrières, J., ... Chiang, C. W. (2009). Low- and high-density lipoprotein cholesterol goal attainment in dyslipidemic women: The Lipid Treatment Assessment Project (L-TAP) 2. American Heart Journal, 158(5), pp. 860-6. doi:10.1016/j.ahj.2009.08.009.
Santos RD, et al. Low- and High-density Lipoprotein Cholesterol Goal Attainment in Dyslipidemic Women: the Lipid Treatment Assessment Project (L-TAP) 2. Am Heart J. 2009;158(5):860-6. PubMed PMID: 19853709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low- and high-density lipoprotein cholesterol goal attainment in dyslipidemic women: The Lipid Treatment Assessment Project (L-TAP) 2. AU - Santos,Raul D, AU - Waters,David D, AU - Tarasenko,Lisa, AU - Messig,Michael, AU - Jukema,J Wouter, AU - Ferrières,Jean, AU - Verdejo,Juan, AU - Chiang,Cheng-Wen, AU - ,, PY - 2009/07/02/received PY - 2009/08/13/accepted PY - 2009/10/27/entrez PY - 2009/10/27/pubmed PY - 2010/1/1/medline SP - 860 EP - 6 JF - American heart journal JO - Am. Heart J. VL - 158 IS - 5 N2 - BACKGROUND: Differences between women and men have been documented for both diagnostic testing and treatment in cardiology. This analysis evaluates whether low-density lipoprotein cholesterol (LDL-C) success rates according to current guidelines and high-density lipoprotein cholesterol (HDL-C) levels differ by gender in the L-TAP 2 population. METHODS: Patients aged > or =20 years with dyslipidemia on stable lipid-lowering therapy were assessed in 9 countries between September 2006 and April 2007. Low-density lipoprotein cholesterol goal attainment by cardiovascular risk level and region and determinants of low HDL-C were compared between genders. RESULTS: Of 9,955 patients (45.3% women) evaluated, women had a significantly lower overall LDL-C success rate than men (71.5% vs 73.7%, P = .014), due entirely to the difference in the high-risk/coronary heart disease (CHD) group (LDL-C goal <100 mg/dL, 62.6% vs 70.6%, P < .0001) Among CHD patients with > or =2 additional risk factors, only 26.7% of women and 31.5% of men (P = .021) attained the optional LDL-C goal of <70 mg/dL. High-density lipoprotein cholesterol was <50 mg/dL in 32.2% of women and <40 mg/dL in 26.8% of men (P < .0001), including 38.2% of women and 29.8% of men in the high risk/CHD group (P < .0001). Predictors of low HDL-C in women included diabetes, smoking, waist circumference, and hypertension. CONCLUSIONS: Cholesterol treatment has improved substantially since the original L-TAP a decade ago, when only 39% of women attained their LDL-C goal. However, high-risk women are undertreated compared to men, and a substantial opportunity remains to reduce their cardiovascular risk. SN - 1097-6744 UR - https://www.unboundmedicine.com/medline/citation/19853709/Low__and_high_density_lipoprotein_cholesterol_goal_attainment_in_dyslipidemic_women:_The_Lipid_Treatment_Assessment_Project__L_TAP__2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8703(09)00636-X DB - PRIME DP - Unbound Medicine ER -