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Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women.
Nutr Res. 2009 Sep; 29(9):609-15.NR

Abstract

Antarctic krill, also known as Euphausia superba, is a marine crustacean rich in both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We tested the hypothesis that krill oil would increase plasma concentrations of EPA and DHA without adversely affecting indicators of safety, tolerability, or selected metabolic parameters. In this randomized, double-blind parallel arm trial, overweight and obese men and women (N = 76) were randomly assigned to receive double-blind capsules containing 2 g/d of krill oil, menhaden oil, or control (olive) oil for 4 weeks. Results showed that plasma EPA and DHA concentrations increased significantly more (P < .001) in the krill oil (178.4 +/- 38.7 and 90.2 +/- 40.3 micromol/L, respectively) and menhaden oil (131.8 +/- 28.0 and 149.9 +/- 30.4 micromol/L, respectively) groups than in the control group (2.9 +/- 13.8 and -1.1 +/- 32.4 micromol/L, respectively). Systolic blood pressure declined significantly more (P < .05) in the menhaden oil (-2.2 +/- 2.0 mm Hg) group than in the control group (3.3 +/- 1.5 mm Hg), and the response in the krill oil group (-0.8 +/- 1.4 mm Hg) did not differ from the other 2 treatments. Blood urea nitrogen declined in the krill oil group as compared with the menhaden oil group (P < .006). No significant differences for other safety variables were noted, including adverse events. In conclusion, 4 weeks of krill oil supplementation increased plasma EPA and DHA and was well tolerated, with no indication of adverse effects on safety parameters.

Authors+Show Affiliations

Provident Clinical Research, Bloomington, IN 47403, USA; Provident Clinical Research, Glen Ellyn, IL 60137, USA. kmaki@providentcrc.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19854375

Citation

Maki, Kevin C., et al. "Krill Oil Supplementation Increases Plasma Concentrations of Eicosapentaenoic and Docosahexaenoic Acids in Overweight and Obese Men and Women." Nutrition Research (New York, N.Y.), vol. 29, no. 9, 2009, pp. 609-15.
Maki KC, Reeves MS, Farmer M, et al. Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutr Res. 2009;29(9):609-15.
Maki, K. C., Reeves, M. S., Farmer, M., Griinari, M., Berge, K., Vik, H., Hubacher, R., & Rains, T. M. (2009). Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. Nutrition Research (New York, N.Y.), 29(9), 609-15. https://doi.org/10.1016/j.nutres.2009.09.004
Maki KC, et al. Krill Oil Supplementation Increases Plasma Concentrations of Eicosapentaenoic and Docosahexaenoic Acids in Overweight and Obese Men and Women. Nutr Res. 2009;29(9):609-15. PubMed PMID: 19854375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women. AU - Maki,Kevin C, AU - Reeves,Mathew S, AU - Farmer,Mildred, AU - Griinari,Mikko, AU - Berge,Kjetil, AU - Vik,Hogne, AU - Hubacher,Rachel, AU - Rains,Tia M, PY - 2009/08/27/received PY - 2009/09/11/revised PY - 2009/09/11/accepted PY - 2009/10/27/entrez PY - 2009/10/27/pubmed PY - 2010/2/24/medline SP - 609 EP - 15 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 9 N2 - Antarctic krill, also known as Euphausia superba, is a marine crustacean rich in both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We tested the hypothesis that krill oil would increase plasma concentrations of EPA and DHA without adversely affecting indicators of safety, tolerability, or selected metabolic parameters. In this randomized, double-blind parallel arm trial, overweight and obese men and women (N = 76) were randomly assigned to receive double-blind capsules containing 2 g/d of krill oil, menhaden oil, or control (olive) oil for 4 weeks. Results showed that plasma EPA and DHA concentrations increased significantly more (P < .001) in the krill oil (178.4 +/- 38.7 and 90.2 +/- 40.3 micromol/L, respectively) and menhaden oil (131.8 +/- 28.0 and 149.9 +/- 30.4 micromol/L, respectively) groups than in the control group (2.9 +/- 13.8 and -1.1 +/- 32.4 micromol/L, respectively). Systolic blood pressure declined significantly more (P < .05) in the menhaden oil (-2.2 +/- 2.0 mm Hg) group than in the control group (3.3 +/- 1.5 mm Hg), and the response in the krill oil group (-0.8 +/- 1.4 mm Hg) did not differ from the other 2 treatments. Blood urea nitrogen declined in the krill oil group as compared with the menhaden oil group (P < .006). No significant differences for other safety variables were noted, including adverse events. In conclusion, 4 weeks of krill oil supplementation increased plasma EPA and DHA and was well tolerated, with no indication of adverse effects on safety parameters. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19854375/Krill_oil_supplementation_increases_plasma_concentrations_of_eicosapentaenoic_and_docosahexaenoic_acids_in_overweight_and_obese_men_and_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00161-4 DB - PRIME DP - Unbound Medicine ER -