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Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis.
J Med Virol. 2009 Dec; 81(12):2079-88.JM

Abstract

Parvovirus B19 (B19V) has been detected in the liver of Asian patients infected with HBV and may contribute to acute and chronic liver disease. This study aimed to investigate the impact of B19V infection in European patients with viral hepatitis. B19V DNA was detected in 1/91 and 0/50 serum samples from patients with chronic hepatitis C and B, respectively. In contrast, B19V DNA was amplified frequently from explanted end-stage liver tissues (37/50, 74%) and from routine biopsy samples (14/32, 44%) (P < 0.05). However, there was no significant difference in B19V copy number per cell between these two groups. B19V-specific CD4(+) T-cell responses to two dominant MHC-class-restricted epitopes were detected in a similar frequency in healthy anti-B19V-positive individuals (3/19; 16%) and patients with chronic hepatitis C (3/13; 23%). These results indicate that B19V can persist in the liver. However, there is no evidence that B19V is a "hepatitis virus" worsening liver disease in European patients with chronic hepatitis C.

Authors+Show Affiliations

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19856479

Citation

Wang, Chun, et al. "Intrahepatic Long-term Persistence of Parvovirus B19 and Its Role in Chronic Viral Hepatitis." Journal of Medical Virology, vol. 81, no. 12, 2009, pp. 2079-88.
Wang C, Heim A, Schlaphoff V, et al. Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis. J Med Virol. 2009;81(12):2079-88.
Wang, C., Heim, A., Schlaphoff, V., Suneetha, P. V., Stegmann, K. A., Jiang, H., Krueger, M., Fytili, P., Schulz, T., Cornberg, M., Kandolf, R., Manns, M. P., Bock, C. T., & Wedemeyer, H. (2009). Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis. Journal of Medical Virology, 81(12), 2079-88. https://doi.org/10.1002/jmv.21638
Wang C, et al. Intrahepatic Long-term Persistence of Parvovirus B19 and Its Role in Chronic Viral Hepatitis. J Med Virol. 2009;81(12):2079-88. PubMed PMID: 19856479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis. AU - Wang,Chun, AU - Heim,Albert, AU - Schlaphoff,Verena, AU - Suneetha,P V, AU - Stegmann,Kerstin A, AU - Jiang,Hong, AU - Krueger,Martin, AU - Fytili,Paraskevi, AU - Schulz,Thomas, AU - Cornberg,Markus, AU - Kandolf,Reinhard, AU - Manns,Michael P, AU - Bock,C Thomas, AU - Wedemeyer,Heiner, PY - 2009/10/27/entrez PY - 2009/10/27/pubmed PY - 2010/1/27/medline SP - 2079 EP - 88 JF - Journal of medical virology JO - J Med Virol VL - 81 IS - 12 N2 - Parvovirus B19 (B19V) has been detected in the liver of Asian patients infected with HBV and may contribute to acute and chronic liver disease. This study aimed to investigate the impact of B19V infection in European patients with viral hepatitis. B19V DNA was detected in 1/91 and 0/50 serum samples from patients with chronic hepatitis C and B, respectively. In contrast, B19V DNA was amplified frequently from explanted end-stage liver tissues (37/50, 74%) and from routine biopsy samples (14/32, 44%) (P < 0.05). However, there was no significant difference in B19V copy number per cell between these two groups. B19V-specific CD4(+) T-cell responses to two dominant MHC-class-restricted epitopes were detected in a similar frequency in healthy anti-B19V-positive individuals (3/19; 16%) and patients with chronic hepatitis C (3/13; 23%). These results indicate that B19V can persist in the liver. However, there is no evidence that B19V is a "hepatitis virus" worsening liver disease in European patients with chronic hepatitis C. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/19856479/Intrahepatic_long_term_persistence_of_parvovirus_B19_and_its_role_in_chronic_viral_hepatitis_ L2 - https://doi.org/10.1002/jmv.21638 DB - PRIME DP - Unbound Medicine ER -