TY - JOUR T1 - The regulatory role of thymic stromal lymphopoietin (TSLP) in maternal-fetal immune tolerance during early human pregnancy. AU - Li,Da-Jin, AU - Guo,Pei-Fen, Y1 - 2009/10/25/ PY - 2009/03/11/received PY - 2009/07/14/revised PY - 2009/07/21/accepted PY - 2009/10/28/entrez PY - 2009/10/28/pubmed PY - 2010/6/9/medline SP - 106 EP - 8 JF - Journal of reproductive immunology JO - J Reprod Immunol VL - 83 IS - 1-2 N2 - Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine, and the functional TSLP receptor (TSLPR) consists of a common IL-7 receptor alpha chain (IL-7Ralpha) and TSLP-specific gamma receptor chain (TSLPR-gamma). It has been demonstrated that TSLP plays an important role in the Th2 bias and regulatory T cell expansion of immune response and tolerance. A successful pregnancy, especially in the early phase, demonstrates features of a Th2 immune response and requires CD4(+)Foxp3(+) regulatory T cell expansion. We have found recently that TSLP-instructed decidual dendritic cells (dDCs) promote decidual CD4(+) T cells to produce Th2-type cytokines including IL-10, which is believed to be a key player in maternal-fetal tolerance. Phenotypic analyses have shown that the expanded cells are mainly CD4(+) Th2 cells and Foxp3(+) regulatory T cells. Our findings show that trophoblasts secrete TSLP that is able to instruct the dDCs to induce CD4(+) Th2 cell and Foxp3(+) regulatory T cell differentiation in decidual CD4(+) T cells. SN - 1872-7603 UR - https://www.unboundmedicine.com/medline/citation/19857905/The_regulatory_role_of_thymic_stromal_lymphopoietin__TSLP__in_maternal_fetal_immune_tolerance_during_early_human_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0378(09)00462-8 DB - PRIME DP - Unbound Medicine ER -