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Anthropometry, body fat, and venous thromboembolism: a Danish follow-up study.

Abstract

BACKGROUND

Obesity, measured as body mass index, is associated with venous thromboembolism (VTE). Body mass index is a marker of excess weight and correlates well with body fat content in adults; however, it fails to consider the distribution of body fat. We assessed the association between anthropometric variables and VTE.

METHODS AND RESULTS

From 1993 to 1997, 27 178 men and 29 876 women 50 to 64 years of age were recruited into a Danish prospective study (Diet, Cancer, and Health). During 10 years of follow-up, the outcome of VTE events was identified in the Danish National Patient Registry and verified by review of medical records. Body weight, body mass index, waist circumference, hip circumference, and total body fat were measured at baseline. We used Cox proportional hazard models to assess the association between anthropometry and VTE. Age was used as a time axis, with further adjustment for smoking, physical activity, height, hypertension, diabetes mellitus, cholesterol, and, among women, use of hormone replacement therapy. We verified 641 incident VTE events and found monotonic dose-response relationships between VTE and all anthropometric measurements in both sexes. In mutually adjusted analyses of waist and hip circumference, we found that hip circumference was positively associated with VTE in women but not in men, whereas waist circumference was positively associated with VTE in men but not in women.

CONCLUSIONS

All measurements of obesity are predictors of the risk for VTE. Positive associations were found between VTE and body weight, body mass index, waist circumference, hip circumference, and total body fat mass.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg Hospital, Sdr. Skovvej 15, DK-9000 Aalborg, Denmark. m.severinsen@rn.dk

    , , , ,

    Source

    Circulation 120:19 2009 Nov 10 pg 1850-7

    MeSH

    Adipose Tissue
    Anthropometry
    Body Mass Index
    Denmark
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Predictive Value of Tests
    Proportional Hazards Models
    Prospective Studies
    Registries
    Risk Factors
    Sex Distribution
    Venous Thromboembolism
    Waist Circumference
    Waist-Hip Ratio

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19858417

    Citation

    Severinsen, Marianne Tang, et al. "Anthropometry, Body Fat, and Venous Thromboembolism: a Danish Follow-up Study." Circulation, vol. 120, no. 19, 2009, pp. 1850-7.
    Severinsen MT, Kristensen SR, Johnsen SP, et al. Anthropometry, body fat, and venous thromboembolism: a Danish follow-up study. Circulation. 2009;120(19):1850-7.
    Severinsen, M. T., Kristensen, S. R., Johnsen, S. P., Dethlefsen, C., Tjønneland, A., & Overvad, K. (2009). Anthropometry, body fat, and venous thromboembolism: a Danish follow-up study. Circulation, 120(19), pp. 1850-7. doi:10.1161/CIRCULATIONAHA.109.863241.
    Severinsen MT, et al. Anthropometry, Body Fat, and Venous Thromboembolism: a Danish Follow-up Study. Circulation. 2009 Nov 10;120(19):1850-7. PubMed PMID: 19858417.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anthropometry, body fat, and venous thromboembolism: a Danish follow-up study. AU - Severinsen,Marianne Tang, AU - Kristensen,Søren Risom, AU - Johnsen,Søren Paaske, AU - Dethlefsen,Claus, AU - Tjønneland,Anne, AU - Overvad,Kim, Y1 - 2009/10/26/ PY - 2009/10/28/entrez PY - 2009/10/28/pubmed PY - 2009/12/16/medline SP - 1850 EP - 7 JF - Circulation JO - Circulation VL - 120 IS - 19 N2 - BACKGROUND: Obesity, measured as body mass index, is associated with venous thromboembolism (VTE). Body mass index is a marker of excess weight and correlates well with body fat content in adults; however, it fails to consider the distribution of body fat. We assessed the association between anthropometric variables and VTE. METHODS AND RESULTS: From 1993 to 1997, 27 178 men and 29 876 women 50 to 64 years of age were recruited into a Danish prospective study (Diet, Cancer, and Health). During 10 years of follow-up, the outcome of VTE events was identified in the Danish National Patient Registry and verified by review of medical records. Body weight, body mass index, waist circumference, hip circumference, and total body fat were measured at baseline. We used Cox proportional hazard models to assess the association between anthropometry and VTE. Age was used as a time axis, with further adjustment for smoking, physical activity, height, hypertension, diabetes mellitus, cholesterol, and, among women, use of hormone replacement therapy. We verified 641 incident VTE events and found monotonic dose-response relationships between VTE and all anthropometric measurements in both sexes. In mutually adjusted analyses of waist and hip circumference, we found that hip circumference was positively associated with VTE in women but not in men, whereas waist circumference was positively associated with VTE in men but not in women. CONCLUSIONS: All measurements of obesity are predictors of the risk for VTE. Positive associations were found between VTE and body weight, body mass index, waist circumference, hip circumference, and total body fat mass. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/19858417/Anthropometry_body_fat_and_venous_thromboembolism:_a_Danish_follow_up_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.109.863241?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -