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Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease.
Neurology. 2009 Oct 27; 73(17):1359-66.Neur

Abstract

BACKGROUND

Previous epidemiologic studies indicate that diabetes mellitus (DM) is associated with cognitive decline and an increased risk of developing Alzheimer disease (AD) in people who do not have dementia. However, little is known about the effect of DM on the rate of cognitive decline in established AD. Our objective was to determine whether DM influences the rate of cognitive decline in patients with AD.

METHODS

A total of 608 patients with a probable diagnosis of AD and a Mini-Mental State Examination (MMSE) score between 10 and 26 were enrolled in a prospective multicenter study. Participants were followed up to 52 (mean 26) months. DM was assessed at baseline (history of DM or antidiabetic medication use). Cognitive function was assessed twice yearly with the MMSE.

RESULTS

Sixty-three participants (10.4%) had DM at baseline. In a mixed model adjusted for sex, age, educational level, dementia severity, cholinesterase inhibitor use, and vascular factors (hypertension, atrial fibrillation, coronary heart disease, and hypercholesterolemia), there were no differences between the groups in MMSE baseline scores (-0.75, p = 0.20), but cognitive decline was slower in the group with DM (0.38, p = 0.01).

CONCLUSIONS

In a cohort of community-dwelling patients with Alzheimer disease (AD), the presence of diabetes mellitus (DM) was associated with a lower rate of cognitive decline. Future studies will need to address the potential impact of DM in the cerebral aging process and to assess the neuropathologic variations in patients with AD with DM.

Authors+Show Affiliations

INSERM U558, 37 allées Jules Guesde, 31073 Toulouse, France. carolinesanz@hotmail.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19858457

Citation

Sanz, C, et al. "Diabetes Is Associated With a Slower Rate of Cognitive Decline in Alzheimer Disease." Neurology, vol. 73, no. 17, 2009, pp. 1359-66.
Sanz C, Andrieu S, Sinclair A, et al. Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease. Neurology. 2009;73(17):1359-66.
Sanz, C., Andrieu, S., Sinclair, A., Hanaire, H., & Vellas, B. (2009). Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease. Neurology, 73(17), 1359-66. https://doi.org/10.1212/WNL.0b013e3181bd80e9
Sanz C, et al. Diabetes Is Associated With a Slower Rate of Cognitive Decline in Alzheimer Disease. Neurology. 2009 Oct 27;73(17):1359-66. PubMed PMID: 19858457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease. AU - Sanz,C, AU - Andrieu,S, AU - Sinclair,A, AU - Hanaire,H, AU - Vellas,B, AU - ,, PY - 2009/10/28/entrez PY - 2009/10/28/pubmed PY - 2009/12/16/medline SP - 1359 EP - 66 JF - Neurology JO - Neurology VL - 73 IS - 17 N2 - BACKGROUND: Previous epidemiologic studies indicate that diabetes mellitus (DM) is associated with cognitive decline and an increased risk of developing Alzheimer disease (AD) in people who do not have dementia. However, little is known about the effect of DM on the rate of cognitive decline in established AD. Our objective was to determine whether DM influences the rate of cognitive decline in patients with AD. METHODS: A total of 608 patients with a probable diagnosis of AD and a Mini-Mental State Examination (MMSE) score between 10 and 26 were enrolled in a prospective multicenter study. Participants were followed up to 52 (mean 26) months. DM was assessed at baseline (history of DM or antidiabetic medication use). Cognitive function was assessed twice yearly with the MMSE. RESULTS: Sixty-three participants (10.4%) had DM at baseline. In a mixed model adjusted for sex, age, educational level, dementia severity, cholinesterase inhibitor use, and vascular factors (hypertension, atrial fibrillation, coronary heart disease, and hypercholesterolemia), there were no differences between the groups in MMSE baseline scores (-0.75, p = 0.20), but cognitive decline was slower in the group with DM (0.38, p = 0.01). CONCLUSIONS: In a cohort of community-dwelling patients with Alzheimer disease (AD), the presence of diabetes mellitus (DM) was associated with a lower rate of cognitive decline. Future studies will need to address the potential impact of DM in the cerebral aging process and to assess the neuropathologic variations in patients with AD with DM. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/19858457/Diabetes_is_associated_with_a_slower_rate_of_cognitive_decline_in_Alzheimer_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=19858457 DB - PRIME DP - Unbound Medicine ER -