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[EIA-IgG antibody measles prevention level estimated from measles neutralizing, particle agglutination and hemagglutination-inhibition antibody titer].
Kansenshogaku Zasshi. 2009 Sep; 83(5):519-24.KZ

Abstract

Measles hemagglutination inhibition (HI) antibody titer, widely used in clinical practice to simply and easily determine the measles immunity level has, in recent years, been increasingly replaced by measles IgG-antibody titer determined by enzyme-immunoassay (EIA). HI antibody titer appears to reflect this protective level, because HI measures the antibody against H protein required for the measles virus to adhere to host cells. EIA-IgG antibody titer does not correlate with the protective level, similar to particle agglutination (PA) titer, because EIA measures different antibodies, including those unrelated to measles protection. After determining HI, PA, neutralizing test (NT) results, and EIA-IgG antibody titer for individual specimens, we compared EIA-IgG antibody titer obtained using an EIA-Kit (Denka Seiken) to HI, PA, and NT titer with the following results: (1) Subjects with EIA-IgG titer of > or = 12.0 may be protected against measles: (2) Subjects with EIA-IgG titer of 4.0 to 8.0 appear to be protected insufficiently requiring a booster dose against measles: (3) Subjects with EIA-IgG titer of 8.0 to 12.0 may benefit from booster vaccination.

Authors+Show Affiliations

Takayama N
Department of Pediatrics, Tokyo Metropolitan Komagome Hospital.
Saika S
No affiliation info available
Ichinohe S
No affiliation info available

MeSH

Antibodies, ViralChild, PreschoolHemagglutination Inhibition TestsHumansImmunoenzyme TechniquesMeaslesMeasles virus

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

jpn

PubMed ID

19860253

Citation

Takayama, Naohide, et al. "[EIA-IgG Antibody Measles Prevention Level Estimated From Measles Neutralizing, Particle Agglutination and Hemagglutination-inhibition Antibody Titer]." Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases, vol. 83, no. 5, 2009, pp. 519-24.
Takayama N, Saika S, Ichinohe S. [EIA-IgG antibody measles prevention level estimated from measles neutralizing, particle agglutination and hemagglutination-inhibition antibody titer]. Kansenshogaku Zasshi. 2009;83(5):519-24.
Takayama, N., Saika, S., & Ichinohe, S. (2009). [EIA-IgG antibody measles prevention level estimated from measles neutralizing, particle agglutination and hemagglutination-inhibition antibody titer]. Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases, 83(5), 519-24.
Takayama N, Saika S, Ichinohe S. [EIA-IgG Antibody Measles Prevention Level Estimated From Measles Neutralizing, Particle Agglutination and Hemagglutination-inhibition Antibody Titer]. Kansenshogaku Zasshi. 2009;83(5):519-24. PubMed PMID: 19860253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [EIA-IgG antibody measles prevention level estimated from measles neutralizing, particle agglutination and hemagglutination-inhibition antibody titer]. AU - Takayama,Naohide, AU - Saika,Shizuko, AU - Ichinohe,Sadato, PY - 2009/10/29/entrez PY - 2009/10/29/pubmed PY - 2009/12/16/medline SP - 519 EP - 24 JF - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases JO - Kansenshogaku Zasshi VL - 83 IS - 5 N2 - Measles hemagglutination inhibition (HI) antibody titer, widely used in clinical practice to simply and easily determine the measles immunity level has, in recent years, been increasingly replaced by measles IgG-antibody titer determined by enzyme-immunoassay (EIA). HI antibody titer appears to reflect this protective level, because HI measures the antibody against H protein required for the measles virus to adhere to host cells. EIA-IgG antibody titer does not correlate with the protective level, similar to particle agglutination (PA) titer, because EIA measures different antibodies, including those unrelated to measles protection. After determining HI, PA, neutralizing test (NT) results, and EIA-IgG antibody titer for individual specimens, we compared EIA-IgG antibody titer obtained using an EIA-Kit (Denka Seiken) to HI, PA, and NT titer with the following results: (1) Subjects with EIA-IgG titer of > or = 12.0 may be protected against measles: (2) Subjects with EIA-IgG titer of 4.0 to 8.0 appear to be protected insufficiently requiring a booster dose against measles: (3) Subjects with EIA-IgG titer of 8.0 to 12.0 may benefit from booster vaccination. SN - 0387-5911 UR - https://www.unboundmedicine.com/medline/citation/19860253/[EIA_IgG_antibody_measles_prevention_level_estimated_from_measles_neutralizing_particle_agglutination_and_hemagglutination_inhibition_antibody_titer]_ L2 - http://www.diseaseinfosearch.org/result/4535 DB - PRIME DP - Unbound Medicine ER -