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Clinical features of the microform cleft lip and the ultrastructural characteristics of the orbicularis oris muscle.
Cleft Palate Craniofac J. 2010 May; 47(3):297-302.CP

Abstract

OBJECTIVE

To clarify the clinical features of the microform cleft lip and to establish the ultrastructural characteristics of the orbicularis muscle.

DESIGN

Clinical observations of the characteristic deformities and associated anomalies were made. Muscle biopsies were harvested for histologic and ultrastructural analyses.

PATIENTS

Seventy-one consecutive patients with microform cleft lip were included in the study. Muscle biopsies were investigated in 11 patients among them.

RESULTS

Nasal deformity, a ridge or a groove from the vermilion to the nostril sill, and interruption of the "white roll" were present in all patients. Lack of a philtral column and a free border notch was observed in over 97% of patients. The orbicularis muscle demonstrated hypoplastic myofibers with nonneurogenic atrophy and focal accumulation of subsarcolemmal mitochondria.

CONCLUSION

The typical gross morphology of the microform cleft lip is a surface manifestation of muscular defect, and the disruption of the muscle further extends down to the ultrastructural level. The clinical features, taken together with the ultrastructural defects of the musculature, might help with a more precise delineation of the microform cleft lip, and provide better understanding of cleft lip in general.

Authors+Show Affiliations

Clinical Fellow of Plastic Surgery, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19860522

Citation

Kim, Eun Key, et al. "Clinical Features of the Microform Cleft Lip and the Ultrastructural Characteristics of the Orbicularis Oris Muscle." The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, vol. 47, no. 3, 2010, pp. 297-302.
Kim EK, Khang SK, Lee TJ, et al. Clinical features of the microform cleft lip and the ultrastructural characteristics of the orbicularis oris muscle. Cleft Palate Craniofac J. 2010;47(3):297-302.
Kim, E. K., Khang, S. K., Lee, T. J., & Kim, T. G. (2010). Clinical features of the microform cleft lip and the ultrastructural characteristics of the orbicularis oris muscle. The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, 47(3), 297-302. https://doi.org/10.5555/08-270.1
Kim EK, et al. Clinical Features of the Microform Cleft Lip and the Ultrastructural Characteristics of the Orbicularis Oris Muscle. Cleft Palate Craniofac J. 2010;47(3):297-302. PubMed PMID: 19860522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of the microform cleft lip and the ultrastructural characteristics of the orbicularis oris muscle. AU - Kim,Eun Key, AU - Khang,Shin Kwang, AU - Lee,Taik Jong, AU - Kim,Tae Gon, PY - 2009/10/29/entrez PY - 2009/10/29/pubmed PY - 2010/12/25/medline SP - 297 EP - 302 JF - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JO - Cleft Palate Craniofac. J. VL - 47 IS - 3 N2 - OBJECTIVE: To clarify the clinical features of the microform cleft lip and to establish the ultrastructural characteristics of the orbicularis muscle. DESIGN: Clinical observations of the characteristic deformities and associated anomalies were made. Muscle biopsies were harvested for histologic and ultrastructural analyses. PATIENTS: Seventy-one consecutive patients with microform cleft lip were included in the study. Muscle biopsies were investigated in 11 patients among them. RESULTS: Nasal deformity, a ridge or a groove from the vermilion to the nostril sill, and interruption of the "white roll" were present in all patients. Lack of a philtral column and a free border notch was observed in over 97% of patients. The orbicularis muscle demonstrated hypoplastic myofibers with nonneurogenic atrophy and focal accumulation of subsarcolemmal mitochondria. CONCLUSION: The typical gross morphology of the microform cleft lip is a surface manifestation of muscular defect, and the disruption of the muscle further extends down to the ultrastructural level. The clinical features, taken together with the ultrastructural defects of the musculature, might help with a more precise delineation of the microform cleft lip, and provide better understanding of cleft lip in general. SN - 1545-1569 UR - https://www.unboundmedicine.com/medline/citation/19860522/Clinical_features_of_the_microform_cleft_lip_and_the_ultrastructural_characteristics_of_the_orbicularis_oris_muscle_ L2 - http://journals.sagepub.com/doi/full/10.1597/08-270.1?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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