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Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta.
Br J Nutr 2010; 103(5):652-62BJ

Abstract

Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In the present study we showed in wild-type mice that chronic ingestion of SFA results in blood-brain barrier (BBB) dysfunction and significant delivery into the brain of plasma proteins, including apo B lipoproteins that are endogenously enriched in amyloid-beta (Abeta). Conversely, the plasma concentration of S100B was used as a marker of brain-to-blood leakage and was found to be increased two-fold because of SFA feeding. Consistent with a deterioration in BBB integrity in SFA-fed mice was a diminished cerebrovascular expression of occludin, an endothelial tight junction protein. In contrast to SFA-fed mice, chronic ingestion of MUFA or PUFA had no detrimental effect on BBB integrity. Utilising highly sensitive three-dimensional immunomicroscopy, we also showed that the cerebral distribution and co-localisation of Abeta with apo B lipoproteins in SFA-fed mice are similar to those found in amyloid precursor protein/presenilin-1 (APP/PS1) amyloid transgenic mice, an established murine model of AD. Moreover, there was a strong positive association of plasma-derived apo B lipoproteins with cerebral Abeta deposits. Collectively, the findings of the present study provide a plausible explanation of how dietary fats may influence AD risk. Ingestion of SFA could enhance peripheral delivery to the brain of circulating lipoprotein-Abeta and exacerbate the amyloidogenic cascade.

Authors+Show Affiliations

Faculty of Health Science, School of Public Health, Curtin University of Technology, Bentley, WA, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19860996

Citation

Takechi, Ryusuke, et al. "Differential Effects of Dietary Fatty Acids On the Cerebral Distribution of Plasma-derived Apo B Lipoproteins With Amyloid-beta." The British Journal of Nutrition, vol. 103, no. 5, 2010, pp. 652-62.
Takechi R, Galloway S, Pallebage-Gamarallage MM, et al. Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. Br J Nutr. 2010;103(5):652-62.
Takechi, R., Galloway, S., Pallebage-Gamarallage, M. M., Wellington, C. L., Johnsen, R. D., Dhaliwal, S. S., & Mamo, J. C. (2010). Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. The British Journal of Nutrition, 103(5), pp. 652-62. doi:10.1017/S0007114509992194.
Takechi R, et al. Differential Effects of Dietary Fatty Acids On the Cerebral Distribution of Plasma-derived Apo B Lipoproteins With Amyloid-beta. Br J Nutr. 2010;103(5):652-62. PubMed PMID: 19860996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. AU - Takechi,Ryusuke, AU - Galloway,Susan, AU - Pallebage-Gamarallage,Menuka M S, AU - Wellington,Cheryl L, AU - Johnsen,Russell D, AU - Dhaliwal,Satvinder S, AU - Mamo,John C L, Y1 - 2009/10/28/ PY - 2009/10/29/entrez PY - 2009/10/29/pubmed PY - 2010/3/20/medline SP - 652 EP - 62 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 103 IS - 5 N2 - Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In the present study we showed in wild-type mice that chronic ingestion of SFA results in blood-brain barrier (BBB) dysfunction and significant delivery into the brain of plasma proteins, including apo B lipoproteins that are endogenously enriched in amyloid-beta (Abeta). Conversely, the plasma concentration of S100B was used as a marker of brain-to-blood leakage and was found to be increased two-fold because of SFA feeding. Consistent with a deterioration in BBB integrity in SFA-fed mice was a diminished cerebrovascular expression of occludin, an endothelial tight junction protein. In contrast to SFA-fed mice, chronic ingestion of MUFA or PUFA had no detrimental effect on BBB integrity. Utilising highly sensitive three-dimensional immunomicroscopy, we also showed that the cerebral distribution and co-localisation of Abeta with apo B lipoproteins in SFA-fed mice are similar to those found in amyloid precursor protein/presenilin-1 (APP/PS1) amyloid transgenic mice, an established murine model of AD. Moreover, there was a strong positive association of plasma-derived apo B lipoproteins with cerebral Abeta deposits. Collectively, the findings of the present study provide a plausible explanation of how dietary fats may influence AD risk. Ingestion of SFA could enhance peripheral delivery to the brain of circulating lipoprotein-Abeta and exacerbate the amyloidogenic cascade. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19860996/Differential_effects_of_dietary_fatty_acids_on_the_cerebral_distribution_of_plasma_derived_apo_B_lipoproteins_with_amyloid_beta_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509992194/type/journal_article DB - PRIME DP - Unbound Medicine ER -