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Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta.

Abstract

Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In the present study we showed in wild-type mice that chronic ingestion of SFA results in blood-brain barrier (BBB) dysfunction and significant delivery into the brain of plasma proteins, including apo B lipoproteins that are endogenously enriched in amyloid-beta (Abeta). Conversely, the plasma concentration of S100B was used as a marker of brain-to-blood leakage and was found to be increased two-fold because of SFA feeding. Consistent with a deterioration in BBB integrity in SFA-fed mice was a diminished cerebrovascular expression of occludin, an endothelial tight junction protein. In contrast to SFA-fed mice, chronic ingestion of MUFA or PUFA had no detrimental effect on BBB integrity. Utilising highly sensitive three-dimensional immunomicroscopy, we also showed that the cerebral distribution and co-localisation of Abeta with apo B lipoproteins in SFA-fed mice are similar to those found in amyloid precursor protein/presenilin-1 (APP/PS1) amyloid transgenic mice, an established murine model of AD. Moreover, there was a strong positive association of plasma-derived apo B lipoproteins with cerebral Abeta deposits. Collectively, the findings of the present study provide a plausible explanation of how dietary fats may influence AD risk. Ingestion of SFA could enhance peripheral delivery to the brain of circulating lipoprotein-Abeta and exacerbate the amyloidogenic cascade.

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  • Authors+Show Affiliations

    ,

    Faculty of Health Science, School of Public Health, Curtin University of Technology, Bentley, WA, Australia.

    , , , , ,

    Source

    The British journal of nutrition 103:5 2010 Mar pg 652-62

    MeSH

    Alzheimer Disease
    Amyloid beta-Peptides
    Animals
    Apolipoprotein B-100
    Biomarkers
    Blood-Brain Barrier
    Brain
    Dietary Fats
    Disease Models, Animal
    Fatty Acids
    Fatty Acids, Unsaturated
    Female
    Membrane Proteins
    Mice
    Mice, Inbred C57BL
    Microscopy
    Occludin
    Presenilin-1
    Risk Factors
    Tissue Distribution

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19860996

    Citation

    Takechi, Ryusuke, et al. "Differential Effects of Dietary Fatty Acids On the Cerebral Distribution of Plasma-derived Apo B Lipoproteins With Amyloid-beta." The British Journal of Nutrition, vol. 103, no. 5, 2010, pp. 652-62.
    Takechi R, Galloway S, Pallebage-Gamarallage MM, et al. Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. Br J Nutr. 2010;103(5):652-62.
    Takechi, R., Galloway, S., Pallebage-Gamarallage, M. M., Wellington, C. L., Johnsen, R. D., Dhaliwal, S. S., & Mamo, J. C. (2010). Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. The British Journal of Nutrition, 103(5), pp. 652-62. doi:10.1017/S0007114509992194.
    Takechi R, et al. Differential Effects of Dietary Fatty Acids On the Cerebral Distribution of Plasma-derived Apo B Lipoproteins With Amyloid-beta. Br J Nutr. 2010;103(5):652-62. PubMed PMID: 19860996.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta. AU - Takechi,Ryusuke, AU - Galloway,Susan, AU - Pallebage-Gamarallage,Menuka M S, AU - Wellington,Cheryl L, AU - Johnsen,Russell D, AU - Dhaliwal,Satvinder S, AU - Mamo,John C L, Y1 - 2009/10/28/ PY - 2009/10/29/entrez PY - 2009/10/29/pubmed PY - 2010/3/20/medline SP - 652 EP - 62 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 103 IS - 5 N2 - Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In the present study we showed in wild-type mice that chronic ingestion of SFA results in blood-brain barrier (BBB) dysfunction and significant delivery into the brain of plasma proteins, including apo B lipoproteins that are endogenously enriched in amyloid-beta (Abeta). Conversely, the plasma concentration of S100B was used as a marker of brain-to-blood leakage and was found to be increased two-fold because of SFA feeding. Consistent with a deterioration in BBB integrity in SFA-fed mice was a diminished cerebrovascular expression of occludin, an endothelial tight junction protein. In contrast to SFA-fed mice, chronic ingestion of MUFA or PUFA had no detrimental effect on BBB integrity. Utilising highly sensitive three-dimensional immunomicroscopy, we also showed that the cerebral distribution and co-localisation of Abeta with apo B lipoproteins in SFA-fed mice are similar to those found in amyloid precursor protein/presenilin-1 (APP/PS1) amyloid transgenic mice, an established murine model of AD. Moreover, there was a strong positive association of plasma-derived apo B lipoproteins with cerebral Abeta deposits. Collectively, the findings of the present study provide a plausible explanation of how dietary fats may influence AD risk. Ingestion of SFA could enhance peripheral delivery to the brain of circulating lipoprotein-Abeta and exacerbate the amyloidogenic cascade. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19860996/Differential_effects_of_dietary_fatty_acids_on_the_cerebral_distribution_of_plasma_derived_apo_B_lipoproteins_with_amyloid_beta_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509992194/type/journal_article DB - PRIME DP - Unbound Medicine ER -