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Nutrient dietary patterns and gastric cancer risk in Italy.
Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):2882-6.CE

Abstract

BACKGROUND

There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns.

METHODS

We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores.

RESULTS

We identified four major dietary patterns, named "animal products", "vitamins and fiber", "vegetable unsaturated fatty acids", and "starch-rich". We observed a positive association between gastric cancer risk and the "animal products" (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the "starch-rich" (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The "vitamins and fiber" pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the "vegetable unsaturated fatty acids" pattern (OR, 0.89; 95% CI, 0.56-1.42).

CONCLUSIONS

Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy. paola.bertuccio@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19861520

Citation

Bertuccio, Paola, et al. "Nutrient Dietary Patterns and Gastric Cancer Risk in Italy." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 11, 2009, pp. 2882-6.
Bertuccio P, Edefonti V, Bravi F, et al. Nutrient dietary patterns and gastric cancer risk in Italy. Cancer Epidemiol Biomarkers Prev. 2009;18(11):2882-6.
Bertuccio, P., Edefonti, V., Bravi, F., Ferraroni, M., Pelucchi, C., Negri, E., Decarli, A., & La Vecchia, C. (2009). Nutrient dietary patterns and gastric cancer risk in Italy. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(11), 2882-6. https://doi.org/10.1158/1055-9965.EPI-09-0782
Bertuccio P, et al. Nutrient Dietary Patterns and Gastric Cancer Risk in Italy. Cancer Epidemiol Biomarkers Prev. 2009;18(11):2882-6. PubMed PMID: 19861520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrient dietary patterns and gastric cancer risk in Italy. AU - Bertuccio,Paola, AU - Edefonti,Valeria, AU - Bravi,Francesca, AU - Ferraroni,Monica, AU - Pelucchi,Claudio, AU - Negri,Eva, AU - Decarli,Adriano, AU - La Vecchia,Carlo, Y1 - 2009/10/27/ PY - 2009/10/29/entrez PY - 2009/10/29/pubmed PY - 2010/1/28/medline SP - 2882 EP - 6 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 18 IS - 11 N2 - BACKGROUND: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. METHODS: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. RESULTS: We identified four major dietary patterns, named "animal products", "vitamins and fiber", "vegetable unsaturated fatty acids", and "starch-rich". We observed a positive association between gastric cancer risk and the "animal products" (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the "starch-rich" (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The "vitamins and fiber" pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the "vegetable unsaturated fatty acids" pattern (OR, 0.89; 95% CI, 0.56-1.42). CONCLUSIONS: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/19861520/Nutrient_dietary_patterns_and_gastric_cancer_risk_in_Italy_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=19861520 DB - PRIME DP - Unbound Medicine ER -