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Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study.
Aliment Pharmacol Ther 2010; 31(2):218-27AP

Abstract

BACKGROUND

The effects of probiotic bacteria in IBS remain controversial.

AIM

To study the effects of a probiotic product on IBS symptoms.

METHODS

We randomized 74 IBS patients to receive 8 weeks of daily treatment with 400 mL milk fermented with the yoghurt bacteria and containing Lactobacillus paracasei, ssp. paracasei F19, Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 (Cultura; active) or acidified milk without these bacteria (control). The primary endpoint was the proportion of subjects reporting adequate relief of their IBS symptoms at least 50% of the weeks. IBS symptom severity, psychological symptoms and quality of life were assessed.

RESULTS

The proportion of responders was 38% (14/37 patients) in the active group and 27% (10/37 patients) in the control group (P = 0.3). IBS symptom severity improved significantly in both groups during the treatment period. This change was greater in the active group during the first 2 weeks, but thereafter, no significant group differences were seen.

CONCLUSIONS

We could not detect a clearly positive effect of fermented milk containing three probiotic bacteria on GI symptoms in IBS patients compared with the control treatment. However, a trend towards a more favourable effect during the first weeks was seen in the active group.

Authors+Show Affiliations

Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. magnus.simren@medicine.gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19863495

Citation

Simrén, M, et al. "Clinical Trial: the Effects of a Fermented Milk Containing Three Probiotic Bacteria in Patients With Irritable Bowel Syndrome - a Randomized, Double-blind, Controlled Study." Alimentary Pharmacology & Therapeutics, vol. 31, no. 2, 2010, pp. 218-27.
Simrén M, Ohman L, Olsson J, et al. Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study. Aliment Pharmacol Ther. 2010;31(2):218-27.
Simrén, M., Ohman, L., Olsson, J., Svensson, U., Ohlson, K., Posserud, I., & Strid, H. (2010). Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study. Alimentary Pharmacology & Therapeutics, 31(2), pp. 218-27. doi:10.1111/j.1365-2036.2009.04183.x.
Simrén M, et al. Clinical Trial: the Effects of a Fermented Milk Containing Three Probiotic Bacteria in Patients With Irritable Bowel Syndrome - a Randomized, Double-blind, Controlled Study. Aliment Pharmacol Ther. 2010 Jan 15;31(2):218-27. PubMed PMID: 19863495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome - a randomized, double-blind, controlled study. AU - Simrén,M, AU - Ohman,L, AU - Olsson,J, AU - Svensson,U, AU - Ohlson,K, AU - Posserud,I, AU - Strid,H, Y1 - 2009/10/26/ PY - 2009/10/30/entrez PY - 2009/10/30/pubmed PY - 2010/7/31/medline SP - 218 EP - 27 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 31 IS - 2 N2 - BACKGROUND: The effects of probiotic bacteria in IBS remain controversial. AIM: To study the effects of a probiotic product on IBS symptoms. METHODS: We randomized 74 IBS patients to receive 8 weeks of daily treatment with 400 mL milk fermented with the yoghurt bacteria and containing Lactobacillus paracasei, ssp. paracasei F19, Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 (Cultura; active) or acidified milk without these bacteria (control). The primary endpoint was the proportion of subjects reporting adequate relief of their IBS symptoms at least 50% of the weeks. IBS symptom severity, psychological symptoms and quality of life were assessed. RESULTS: The proportion of responders was 38% (14/37 patients) in the active group and 27% (10/37 patients) in the control group (P = 0.3). IBS symptom severity improved significantly in both groups during the treatment period. This change was greater in the active group during the first 2 weeks, but thereafter, no significant group differences were seen. CONCLUSIONS: We could not detect a clearly positive effect of fermented milk containing three probiotic bacteria on GI symptoms in IBS patients compared with the control treatment. However, a trend towards a more favourable effect during the first weeks was seen in the active group. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/19863495/Clinical_trial:_the_effects_of_a_fermented_milk_containing_three_probiotic_bacteria_in_patients_with_irritable_bowel_syndrome___a_randomized_double_blind_controlled_study_ L2 - https://doi.org/10.1111/j.1365-2036.2009.04183.x DB - PRIME DP - Unbound Medicine ER -